Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children

Therapeutic guidelines for prescribing antibiotics in neonates should be evidence-based: a French national survey

(2015) Stéphanie Leroux et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Drug-induced acute kidney injury in children

(2015) Lauren N. Faught et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cystatin C as a potential biomarker for dosing of renally excreted drugs

(2015) Nguessan Aimé Brou et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Prediction of Voriconazole Non-linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach

(2015) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

Challenges and considerations for development of therapeutic proteins in pediatric patients

(2015) Yi Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Physiological responses to hypothermia

(2015) Thomas Wood et al.   Seminars in Fetal & Neonatal Medicine

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology

(2014) Charlotte I.S. Barker et al.   ADVANCED DRUG DELIVERY REVIEWS

Factors Associated With Acute Kidney Injury in Children Receiving Vancomycin

(2014) Elizabeth A. Sinclair et al.   ANNALS OF PHARMACOTHERAPY

Drug metabolism for the paediatrician

(2014) S. N. de Wildt et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Prediction of tumour response induced by chemotherapy using modelling of CA-125 kinetics in recurrent ovarian cancer patients

(2014) M Wilbaux et al.   BRITISH JOURNAL OF CANCER

The impact of age andCYP2C9andVKORC1variants on stable warfarin dose in the paediatric population

(2014) Susan I. Vear et al.   BRITISH JOURNAL OF HAEMATOLOGY

Subcutaneous immunoglobulin loading regimens for previously untreated patients with primary antibody deficiency

(2014) M. Rojavin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Enzymatic isotope dilution mass spectrometry (IDMS) traceable serum creatinine is preferable over Jaffe in neonates and young infants

(2014) Karel Allegaert et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

A Physiologically Based Pharmacokinetic Model for Voriconazole Disposition Predicts Intestinal First-pass Metabolism in Children

(2014) Nicole R. Zane et al.   CLINICAL PHARMACOKINETICS

Comparing Dosage Adjustment Methods for Once-Daily Tobramycin in Paediatric and Adolescent Patients with Cystic Fibrosis

(2014) Stefanie Hennig et al.   CLINICAL PHARMACOKINETICS

How to optimize the evaluation and use of antibiotics in neonates

(2014) Johannes N. van den Anker   EARLY HUMAN DEVELOPMENT

Dynamic modeling in ovarian cancer: An original approach linking early changes in modeled longitudinal CA-125 kinetics and survival to help decisions in early drug development

(2014) Mélanie Wilbaux et al.   GYNECOLOGIC ONCOLOGY

Implications of serum creatinine measurements on GFR estimation and vancomycin dosing in children

(2014) Gal Neuman et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Clinical Pharmacology in Neonates: Small Size, Huge Variability

(2014) Karel Allegaert et al.   Neonatology

VKORC1andCYP2C9genotypes are predictors of warfarin-related outcomes in children

(2014) Kaitlyn Shaw et al.   PEDIATRIC BLOOD & CANCER

Early markers of obesity-related renal injury in childhood

(2014) Wei Ding et al.   PEDIATRIC NEPHROLOGY

Urinary TIMP-2 and IGFBP7 as Early Biomarkers of Acute Kidney Injury and Renal Recovery following Cardiac Surgery

(2014) Melanie Meersch et al.   PLoS One

Changes in Metabolic Profiles during Acute Kidney Injury and Recovery following Ischemia/Reperfusion

(2014) Qingqing Wei et al.   PLoS One

Dosage individualization in children: integration of pharmacometrics in clinical practice

(2014) Wei Zhao et al.   World Journal of Pediatrics

Metabolomics applied in neonatology

(2014) Nicoletta Iacovidou et al.   Bioanalysis

Perinatal Pharmacology

(2014) Karel Allegaert et al.   Biomed Research International

A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam

(2013) A. R. Maharaj et al.   AAPS Journal

Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants

(2013) Jane P. F. Bai et al.   AAPS Journal

Association of carbamazepine-induced severe cutaneous drug reactions and HLA-B*1502 allele status, and dose and treatment duration in paediatric neurology patients in Singapore

(2013) K. W. Chong et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Towards evidence-based dosing regimens in children on the basis of population pharmacokinetic pharmacodynamic modelling

(2013) Rick Admiraal et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Paediatric models in motion: requirements for model-based decision support at the bedside

(2013) Jeffrey S. Barrett   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Amikacin population pharmacokinetics among paediatric burn patients

(2013) Catherine M.T. Sherwin et al.   BURNS

NGAL, L-FABP, and KIM-1 in comparison to established markers of renal dysfunction

(2013) Leon Holzscheiter et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Amikacin Maturation Model as a Marker of Renal Maturation to Predict Glomerular Filtration Rate and Vancomycin Clearance in Neonates

(2013) Wei Zhao et al.   CLINICAL PHARMACOKINETICS

The Role of Pharmacogenetics in the Disposition of and Response to Tacrolimus in Solid Organ Transplantation

(2013) Dennis A. Hesselink et al.   CLINICAL PHARMACOKINETICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update

(2013) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lack of a relationship between the serum concentration of aminoglycosides and ototoxicity in neonates

(2013) Rianto Setiabudy et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport

(2013) Catherine K. Yeung et al.   KIDNEY INTERNATIONAL

Neonatal clinical pharmacology

(2013) Karel Allegaert et al.   PEDIATRIC ANESTHESIA

Measuring Cystatin C to Determine Renal Function in Neonates

(2013) Yogavijayan Kandasamy et al.   Pediatric Critical Care Medicine

Urinary metabolomic markers of aminoglycoside nephrotoxicity in newborn rats

(2013) Mina H. Hanna et al.   PEDIATRIC RESEARCH

Pharmacogenetics in clinical pediatrics: challenges and strategies

(2013) Sara L Van Driest et al.   Personalized Medicine

A Neonatal Amikacin Covariate Model Can Be Used to Predict Ontogeny of Other Drugs Eliminated Through Glomerular Filtration in Neonates

(2013) Roosmarijn F. W. De Cock et al.   PHARMACEUTICAL RESEARCH

CYP3A4*22andCYP3Acombined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients

(2013) Violette MGJ Gijsen et al.   PHARMACOGENOMICS

Role of the Functional Toll-Like Receptor-9 Promoter Polymorphism (-1237T/C) in Increased Risk of End-Stage Renal Disease: A Case-Control Study

(2013) Hsin-Yi Yang et al.   PLoS One

Pharmacokinetic Modeling and Simulation of Biweekly Subcutaneous Immunoglobulin Dosing in Primary Immunodeficiency

(2013) Cornelia B. Landersdorfer et al.   POSTGRADUATE MEDICINE

P450 Oxidoreductase *28 (POR*28) and Tacrolimus Disposition in Pediatric Kidney Transplant Recipients—A Pilot Study

(2013) Violette M. G. J. Gijsen et al.   THERAPEUTIC DRUG MONITORING

Kidney disease in children and adolescents with perinatal HIV-1 infection

(2013) Rajendra Bhimma et al.   Journal of the International AIDS Society

Rapid Sample Size Calculations for a Defined Likelihood Ratio Test-Based Power in Mixed-Effects Models

(2012) Camille Vong et al.   AAPS Journal

CKiD (CKD in Children) Prospective Cohort Study: A Review of Current Findings

(2012) Cynthia J. Wong et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Performance of Urinary Liver-Type Fatty Acid–Binding Protein in Acute Kidney Injury: A Meta-analysis

(2012) Paweena Susantitaphong et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration

(2012) H.A.M. Mutsaers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TheCYP3A4*22allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations

(2012) Laure Elens et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences

(2012) Aldo Clerico et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Therapeutic Drug Monitoring of Imatinib

(2012) Verena Gotta et al.   CLINICAL PHARMACOKINETICS

Benchmarking Therapeutic Drug Monitoring Software: A Review of Available Computer Tools

(2012) Aline Fuchs et al.   CLINICAL PHARMACOKINETICS

Maturation of the Glomerular Filtration Rate in Neonates, as Reflected by Amikacin Clearance

(2012) Roosmarijn F.W. De Cock et al.   CLINICAL PHARMACOKINETICS

Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

(2012) J S Barrett et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

(2012) R Leong et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetics of Aminoglycosides in the Newborn

(2012) Johannes N. van den Anker et al.   CURRENT PHARMACEUTICAL DESIGN

Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia

(2012) Tiphaine Adam de Beaumais et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin

(2012) George G Zhanel et al.   Expert Review of Anti-Infective Therapy

Pharmacogenomics of adverse drug reactions: implementing personalized medicine

(2012) C.-Y. Wei et al.   HUMAN MOLECULAR GENETICS

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Optimizing Drug Development and Use in Patients With Kidney Disease: Opportunities, Innovations, and Challenges

(2012) Marc Pfister et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Novel Dialysis Modalities: Do We Need New Metrics to Optimize Treatment?

(2012) Rachel Fisseli et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Design, Conduct, Analysis, and Interpretation of Clinical Studies in Patients With Impaired Kidney Function

(2012) Michael A. Tortorici et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Pharmacometric Approach to Quantify the Impact of Chronic Kidney Disease and Hemodialysis on Systemic Drug Exposure: Application to Saxagliptin

(2012) Liping Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Regulatory Perspectives on Designing Pharmacokinetic Studies and Optimizing Labeling Recommendations for Patients With Chronic Kidney Disease

(2012) Lei Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Current Understanding of Drug Disposition in Kidney Disease

(2012) Judith Naud et al.   JOURNAL OF CLINICAL PHARMACOLOGY

CYP2D6 Genotype Information to Guide Pimozide Treatment in Adult and Pediatric Patients

(2012) Hobart L. Rogers et al.   JOURNAL OF CLINICAL PSYCHIATRY

Metabolomics in the Developing Human Being

(2012) Aggeliki Syggelou et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Pediatric Pharmacokinetics

(2012) Ryan S. Funk et al.   PEDIATRIC CLINICS OF NORTH AMERICA

The Impact of Extracorporeal Life Support and Hypothermia on Drug Disposition in Critically Ill Infants and Children

(2012) Enno D. Wildschut et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Cystatin C in children on chronic hemodialysis

(2012) Olivera Marsenic et al.   PEDIATRIC NEPHROLOGY

Evaluation of Serum Creatinine Concentration-Based Glomerular Filtration Rate Equations in Pediatric Patients with Chronic Kidney Disease

(2012) Carlton K. K. Lee et al.   PHARMACOTHERAPY

Metabolomics in neonatology: Fact or fiction?

(2012) V. Fanos et al.   Seminars in Fetal & Neonatal Medicine

Effect of hypothermia and extracorporeal life support on drug disposition in neonates

(2012) Enno D. Wildschut et al.   Seminars in Fetal & Neonatal Medicine

Clinical evaluation of analytical variations in serum creatinine measurements: why laboratories should abandon Jaffe techniques

(2012) Iefke Drion et al.   BMC Nephrology

Comparison of Measured GFR, Serum Creatinine, Cystatin C, and Beta-Trace Protein to Predict ESRD in African Americans With Hypertensive CKD

(2011) Nrupen A. Bhavsar et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Model-Based Approach for Optimization of Atazanavir Dose Recommendations for HIV-Infected Pediatric Patients

(2011) Ying Hong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children

(2011) T. T. Biss et al.   BLOOD

A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients

(2011) L. Elens et al.   CLINICAL CHEMISTRY

Acute Kidney Injury and Increasing Nephrotoxic-Medication Exposure in Noncritically-Ill Children

(2011) B. S. Moffett et al.   Clinical Journal of the American Society of Nephrology

Impact of Pharmacometric Analyses on New Drug Approval and Labelling Decisions

(2011) Joo Yeon Lee et al.   CLINICAL PHARMACOKINETICS

Biomarkers for the early detection of acute kidney injury

(2011) Prasad Devarajan   CURRENT OPINION IN PEDIATRICS

Modelling and simulation as research tools in paediatric drug development

(2011) Francesco Bellanti et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The interactions of age, genetics, and disease severity on tacrolimus dosing requirements after pediatric kidney and liver transplantation

(2011) Saskia N. de Wildt et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Optimizing Drug Development and Use in Patients With Kidney Disease

(2011) Thomas D. Nolin et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Clinical Pharmacology Basis of Deriving Dosing Recommendations for Dabigatran in Patients With Severe Renal Impairment

(2011) Sudharshan Hariharan et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients

(2011) Violette Gijsen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

General Principles of Antimicrobial Therapy

(2011) Surbhi Leekha et al.   MAYO CLINIC PROCEEDINGS

Albumin-binding capacity (ABiC) is reduced in patients with chronic kidney disease along with an accumulation of protein-bound uraemic toxins

(2011) S. Klammt et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan

(2011) Pei Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of modeling and simulation in pediatric investigation plans

(2011) Efthymios Manolis et al.   PEDIATRIC ANESTHESIA

KIM-1 and NGAL: new markers of obstructive nephropathy

(2011) Anna Wasilewska et al.   PEDIATRIC NEPHROLOGY

The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients

(2011) Hylke de Jonge et al.   PHARMACOGENOMICS

Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults

(2011) Eva Fernandez et al.   Pharmaceutics

Question 2 Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?

(2010) S. Ganesan et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Application of Individualized Bayesian Urea Kinetic Modeling to Pediatric Hemodialysis

(2010) Olivera Marsenic et al.   ASAIO JOURNAL

Serum Creatinine, Cystatin C, and  -Trace Protein in Diagnostic Staging and Predicting Progression of Primary Nondiabetic Chronic Kidney Disease

(2010) K. S. Spanaus et al.   CLINICAL CHEMISTRY

The Need for Modeling and Simulation to Design Clinical Investigations in Children

(2010) Pravin R. Jadhav et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The Emerging Scientific Discipline of Pharmacometrics

(2010) Marc Pfister et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetic and Pharmacodynamic Basis for Effective Argatroban Dosing in Pediatrics

(2010) Rajanikanth Madabushi et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The efficacy and toxicity of two dosing-regimens of amikacin in neonates with sepsis

(2010) E. Abdel-Hady et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Incidence and Risk Factors Influencing the Development of Vancomycin Nephrotoxicity in Children

(2010) Susan McKamy et al.   JOURNAL OF PEDIATRICS

Serum cystatin C for estimation of residual renal function in children on peritoneal dialysis

(2010) Su Jin Kim et al.   PEDIATRIC NEPHROLOGY

Residual renal function assessment with cystatin C

(2010) Guido Filler et al.   PEDIATRIC NEPHROLOGY

Pharmacometrics-Based Dose Selection of Levofloxacin as a Treatment for Postexposure Inhalational Anthrax in Children

(2009) F. Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant

(2009) Ahmed F. Hawwa et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

What is the right dose for children?

(2009) Massimo Cella et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Impact of Gestational Age and Birth Weight on Amikacin Clearance on Day 1 of Life

(2009) M. F. Schreuder et al.   Clinical Journal of the American Society of Nephrology

Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Progression of Chronic Kidney Disease

(2009) D. Bolignano et al.   Clinical Journal of the American Society of Nephrology

Facilitation of Drug Evaluation in Children by Population Methods and Modelling†

(2009) Michel Tod et al.   CLINICAL PHARMACOKINETICS

Drug Dosing in Patients With Impaired Renal Function

(2009) D C Brater   CLINICAL PHARMACOLOGY & THERAPEUTICS

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity

(2009) K K Filipski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Nephropharmacology: Drugs and the Kidney

(2009) A J Atkinson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0

(2009) Caroline Bazzoli et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Individualised dosing of amikacin in neonates: a pharmacokinetic/pharmacodynamic analysis

(2009) Catherine M. T. Sherwin et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The impact of ibuprofen or indomethacin on renal drug clearance in neonates

(2009) Karel Allegaert   Journal of Maternal-Fetal & Neonatal Medicine

Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease

(2009) Trevor N Johnson et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Asymmetric dimethylarginine is closely associated with the development and progression of nephropathy in patients with type 2 diabetes

(2009) K. Hanai et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Leveraging prior quantitative knowledge in guiding pediatric drug development: a case study

(2009) Pravin R. Jadhav et al.   PHARMACEUTICAL STATISTICS

Pharmacokinetics and Therapeutic Drug Monitoring of Psychotropic Drugs in Pediatrics

(2009) Simona Pichini et al.   THERAPEUTIC DRUG MONITORING

Concepts and Challenges in Quantitative Pharmacology and Model-Based Drug Development

(2008) Liping Zhang et al.   AAPS Journal

Neutrophil Gelatinase–Associated Lipocalin (NGAL) as a Marker of Kidney Damage

(2008) Davide Bolignano et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Emerging Evidence of the Impact of Kidney Disease on Drug Metabolism and Transport

(2008) TD Nolin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical pharmacokinetics of aminoglycosides in the neonate: a review

(2008) Gian Maria Pacifici   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity

(2008) Steven N Hart et al.   Expert Opinion on Drug Metabolism & Toxicology

The effect of chronic renal failure on drug metabolism and transport

(2008) Albert W Dreisbach et al.   Expert Opinion on Drug Metabolism & Toxicology

Integration of modelling and simulation into the development of intravenous busulfan in paediatrics: an industrial experience

(2008) L. Nguyen   FUNDAMENTAL & CLINICAL PHARMACOLOGY

IL-18 Contributes to Renal Damage after Ischemia-Reperfusion

(2008) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nephrotoxicity as a cause of acute kidney injury in children

(2008) Ludwig Patzer   PEDIATRIC NEPHROLOGY

Effects of Uremic Serum and Uremic Toxins on Hepatic Uptake of Digoxin

(2008) Masayuki Tsujimoto et al.   THERAPEUTIC DRUG MONITORING

Determinants of Aciclovir-Induced Nephrotoxicity in Children

(2008) Ruth Schreiber et al.   PEDIATRIC DRUGS