Drug metabolism for the paediatrician

A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

(2014) Farzaneh Salem et al.   CLINICAL PHARMACOKINETICS

Evidence-Based Morphine Dosing for Postoperative Neonates and Infants

(2014) Elke H. J. Krekels et al.   CLINICAL PHARMACOKINETICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update

(2014) K R Crews et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

VKORC1andCYP2C9genotypes are predictors of warfarin-related outcomes in children

(2014) Kaitlyn Shaw et al.   PEDIATRIC BLOOD & CANCER

Understanding dosing: children are small adults, neonates are immature children

(2013) B. J. Anderson et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations

(2013) Ibrahim Ince et al.   CLINICAL PHARMACOKINETICS

Role of TPMT and COMT genetic variation in cisplatin-induced ototoxicity

(2013) B C Carleton et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update

(2013) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Therapeutic Hypothermia Decreases Phenytoin Elimination in Children with Traumatic Brain Injury*

(2013) Philip E. Empey et al.   CRITICAL CARE MEDICINE

Safety of fluconazole in paediatrics: a systematic review

(2013) Oluwaseun Egunsola et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification

(2013) Andrew Rowland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature

(2013) Farzaneh Salem et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Fluticasone Propionate Pharmacogenetics: CYP3A4*22 Polymorphism and Pediatric Asthma Control

(2013) Chris Stockmann et al.   JOURNAL OF PEDIATRICS

Pharmacogenetics in clinical pediatrics: challenges and strategies

(2013) Sara L Van Driest et al.   Personalized Medicine

PHASE II DRUG METABOLIZING ENZYMES

(2012) Petra Jancova et al.   BIOMEDICAL PAPERS-OLOMOUC

Ontogeny of Hepatic Glucuronidation; Methods and Results

(2012) Elke H.J. Krekels et al.   CURRENT DRUG METABOLISM

Lack of toxicity after paracetamol overdose in a extremely preterm neonate

(2012) Roser Porta et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

CYP2D6 Genotype Information to Guide Pimozide Treatment in Adult and Pediatric Patients

(2012) Hobart L. Rogers et al.   JOURNAL OF CLINICAL PSYCHIATRY

The Impact of Extracorporeal Life Support and Hypothermia on Drug Disposition in Critically Ill Infants and Children

(2012) Enno D. Wildschut et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Critical Illness Is a Major Determinant of Midazolam Clearance in Children Aged 1 Month to 17 Years

(2012) Ibrahim Ince et al.   THERAPEUTIC DRUG MONITORING

VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children

(2011) T. T. Biss et al.   BLOOD

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing

(2011) J A Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The effect of inflammation on drug metabolism: a focus on pediatrics

(2011) Nienke J. Vet et al.   DRUG DISCOVERY TODAY

The interactions of age, genetics, and disease severity on tacrolimus dosing requirements after pediatric kidney and liver transplantation

(2011) Saskia N. de Wildt et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children

(2011) Saskia N de Wildt   Expert Opinion on Drug Metabolism & Toxicology

Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients

(2011) Violette Gijsen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia

(2011) Jennifer R. Donnan et al.   PEDIATRIC BLOOD & CANCER

Population Pharmacokinetics of Midazolam and Its Metabolites during Venoarterial Extracorporeal Membrane Oxygenation in Neonates

(2010) Maurice J. Ahsman et al.   CLINICAL PHARMACOKINETICS

Tacrolimus nephrotoxicity: beware of the association of diarrhea, drug interaction and pharmacogenetics

(2010) Sandrine Leroy et al.   PEDIATRIC NEPHROLOGY

Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years

(2009) Catherijne A.J. Knibbe et al.   CLINICAL PHARMACOKINETICS

Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol

(2009) M. Chen et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3

(2009) S. B. Yanni et al.   DRUG METABOLISM AND DISPOSITION

Variation in Care in Pediatric Crohn Disease

(2009) Richard B Colletti et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Tailor-made drug treatment for children

(2008) Ibrahim Ince et al.   DRUG DISCOVERY TODAY

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS