Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing

(2011) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease

(2011) Liang Ding et al.   INFLAMMATORY BOWEL DISEASES

Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy

(2010) Tiphaine Adam de Beaumais et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Genetic Variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS Genes in Japanese Individuals

(2010) Mutsumi Kudo et al.   Drug Metabolism and Pharmacokinetics

Understanding the Relative Roles of Pharmacogenetics and Ontogeny in Pediatric Drug Development and Regulatory Science

(2010) J. Steven Leeder et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

(2010) Hiromistu Ban et al.   JOURNAL OF GASTROENTEROLOGY

Thiopurine pathway

(2010) Gianluigi Zaza et al.   Pharmacogenetics and Genomics

Suivi thérapeutique pharmacologique des 6-thioguanine nucléotides dans les leucémies aigues lymphoblastiques de l’enfant : intérêt et limites

(2010) May Fakhoury et al.   THERAPIE

S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts

(2009) Miha Milek et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of a novel TPMT mutation associated with azathioprine-induced myelosuppression

(2009) Tiphaine Adam de Beaumais et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma

(2009) Rikke L. Hedeland et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

5,10-Methylenetetrahydrofolate reductase (MTHFR) low activity genotypes reduce the risk of relapse-related acute lymphoblastic leukemia (ALL)

(2009) Natasa Karas Kuzelicki et al.   LEUKEMIA RESEARCH

Characterization of the Inosine Triphosphatase (ITPA) Gene: Haplotype Structure, Haplotype-Phenotype Correlation and Promoter Function

(2009) Nicolas von Ahsen et al.   THERAPEUTIC DRUG MONITORING

Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine

(2008) Ahmed F. Hawwa et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

(2008) G Stocco et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4

(2008) Daniel Janke et al.   HUMAN MUTATION

Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients

(2008) N Karas-Kuzelicki et al.   LEUKEMIA

Functional characterization of human xanthine oxidase allelic variants

(2008) Mutsumi Kudo et al.   Pharmacogenetics and Genomics

Association of four DNA polymorphisms with acute rejection after kidney transplantation

(2008) Josep Grinyó et al.   TRANSPLANT INTERNATIONAL

IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations

(2007) Sofie Haglund et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY