Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

(2014) Hazel England et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Independent Resistance to Aspergillus fumigatus in Alveolar Macrophages

(2014) E. J. Cornish et al.   JOURNAL OF IMMUNOLOGY

Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection

(2014) Kelly M. Shepardson et al.   PLoS Pathogens

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

(2014) Mark S. Gresnigt et al.   PLoS Pathogens

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency

(2013) A. Drewniak et al.   BLOOD

C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection

(2013) Le-Le Zhu et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

IL-1  Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo

(2013) K. C. Barry et al.   JOURNAL OF IMMUNOLOGY

HuR Is Required for IL-17-Induced Act1-Mediated CXCL1 and CXCL5 mRNA Stabilization

(2013) T. Herjan et al.   JOURNAL OF IMMUNOLOGY

Deep Dermatophytosis and Inherited CARD9 Deficiency

(2013) Fanny Lanternier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-1α

(2013) Peleg Rider et al.   SEMINARS IN IMMUNOLOGY

Human Genetic Susceptibility to Invasive Aspergillosis

(2013) Cristina Cunha et al.   PLoS Pathogens

The IL-36 receptor pathway regulatesAspergillus fumigatus-induced Th1 and Th17 responses

(2012) Mark S. Gresnigt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

Intrapulmonary Administration of Leukotriene B4 Augments Neutrophil Accumulation and Responses in the Lung to Klebsiella Infection in CXCL1 Knockout Mice

(2012) S. Batra et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Dectin-1 and DC-SIGN Polymorphisms Associated with Invasive Pulmonary Aspergillosis Infection

(2012) Juan Sainz et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung

(2012) Anupam Jhingran et al.   Cell Reports

Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling

(2011) Katrin Volling et al.   CELLULAR MICROBIOLOGY

Interleukin-1β Regulates CXCL8 Release and Influences Disease Outcome in Response to Streptococcus pneumoniae, Defining Intercellular Cooperation between Pulmonary Epithelial Cells and Macrophages

(2011) Helen M. Marriott et al.   INFECTION AND IMMUNITY

Airway Epithelial MyD88 Restores Control of Pseudomonas aeruginosa Murine Infection via an IL-1-Dependent Pathway

(2011) L. A. Mijares et al.   JOURNAL OF IMMUNOLOGY

Nonhematopoietic Cells Are Key Players in Innate Control of Bacterial Airway Infection

(2011) S. LeibundGut-Landmann et al.   JOURNAL OF IMMUNOLOGY

In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

(2011) Nora Grahl et al.   PLoS Pathogens

Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity

(2010) C. Cunha et al.   BLOOD

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

The Small GTPase RacA Mediates Intracellular Reactive Oxygen Species Production, Polarized Growth, and Virulence in the Human Fungal Pathogen Aspergillus fumigatus

(2010) Haiyan Li et al.   EUKARYOTIC CELL

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

CXCL1 Regulates Pulmonary Host Defense to Klebsiella Infection via CXCL2, CXCL5, NF- B, and MAPKs

(2010) S. Cai et al.   JOURNAL OF IMMUNOLOGY

Immunogenetics of invasive aspergillosis

(2010) Frédéric Lamoth et al.   MEDICAL MYCOLOGY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection

(2009) Tobias M. Hohl et al.   Cell Host & Microbe

Selective Expansion of the Monocytic Lineage Directed by Bacterial Infection

(2009) N. V. Serbina et al.   JOURNAL OF IMMUNOLOGY

MyD88 and Type I Interferon Receptor-Mediated Chemokine Induction and Monocyte Recruitment during Listeria monocytogenes Infection

(2009) T. Jia et al.   JOURNAL OF IMMUNOLOGY

Requisite Role for the Dectin-1  -Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus

(2009) J. L. Werner et al.   JOURNAL OF IMMUNOLOGY

Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points followingAspergillus fumigatusInfection

(2009) Monica M. Mircescu et al.   JOURNAL OF INFECTIOUS DISEASES

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Aspergillosis

(2009) Brahm H. Segal   NEW ENGLAND JOURNAL OF MEDICINE

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Aspergillus fumigatus-induced Interleukin-8 Synthesis by Respiratory Epithelial Cells Is Controlled by the Phosphatidylinositol 3-Kinase, p38 MAPK, and ERK1/2 Pathways and Not by the Toll-like Receptor-MyD88 Pathway

(2008) Viviane Balloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL1 Gene Cluster Polymorphisms and Its Haplotypes may Predict the Risk to Develop Invasive Pulmonary Aspergillosis and Modulate C-reactive Protein Level

(2008) J. Sainz et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Toll-like Receptor 4 Polymorphisms and Aspergillosis in Stem-Cell Transplantation

(2008) Pierre-Yves Bochud et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE