Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Identification of potent and selective MTH1 inhibitors

(2016) Alessia Petrocchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

(2016) Jason G. Kettle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of matrix metalloproteinase inhibitors by chemical arrays

(2015) Makoto Kawatani et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Methyl 3-((6-Methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods

(2015) Hidemitsu Minegishi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A small molecule that induces reactive oxygen species via cellular glutathione depletion

(2014) Tatsuro Kawamura et al.   BIOCHEMICAL JOURNAL

Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells

(2014) Yusaku Nakabeppu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

(2014) Kilian V. M. Huber et al.   NATURE

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

(2014) A Patel et al.   ONCOGENE

An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase

(2013) Manuel Streib et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Affinity-based screening of MDM2/MDMX–p53 interaction inhibitors by chemical array: Identification of novel peptidic inhibitors

(2013) Taro Noguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and Characterization of an Inhibitor of Trichothecene 3-O-Acetyltransferase, TRI101, by the Chemical Array Approach

(2013) Yuichi NAKAJIMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Identification of a Molecular Target of a Novel Fungal Metabolite, Pyrrolizilactone, by Phenotypic Profiling Systems

(2013) Yushi Futamura et al.   CHEMBIOCHEM

Recent discoveries and applications involving small-molecule microarrays

(2013) Jiyoung A Hong et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells

(2013) R Yao et al.   ONCOGENE

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Boron-Based Inhibitors of Acyl Protein Thioesterases 1 and 2

(2012) Tobias J. Zimmermann et al.   CHEMBIOCHEM

Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

(2012) Yushi Futamura et al.   CHEMISTRY & BIOLOGY

Construction of a microbial natural product library for chemical biology studies

(2012) Naoki Kato et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity

(2011) Shun Minagawa et al.   BIOCHEMICAL JOURNAL

Identification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic Profiling

(2011) Makoto Kawatani et al.   CHEMISTRY & BIOLOGY

Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

(2011) Marco Bürger et al.   JOURNAL OF LIPID RESEARCH

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

(2011) J. Jean Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Introduction of New Tools for Chemical Biology Research on Microbial Metabolites

(2010) Hiroyuki OSADA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action

(2010) Makoto Muroi et al.   CHEMISTRY & BIOLOGY

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

(2010) Isao Miyazaki et al.   Nature Chemical Biology

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence

(2010) P Rai et al.   ONCOGENE

Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

(2009) Meihua Luo et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II

(2008) Isao MIYAZAKI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis

(2008) Y Tamura et al.   ONCOGENE