Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 77, Issue 9, Pages 1958-1960Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.130153
Keywords
chemical array; chemical library; Fusarium graminearum; mycotoxin inhibitor; trichothecene; mycotoxin
Categories
Funding
- Programme for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry
- Grants-in-Aid for Scientific Research [25750397, 23510287, 23580125] Funding Source: KAKEN
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Trichothecene 3-O-acetyltransferase (TRI101) is an indispensable enzyme for the biosynthesis of trichothecenes, a group of mycotoxins produced by Fusarium graminearum. In this study, an inhibitor of TRI101 was identified by chemical array analysis using compounds from the RIKEN Natural Products Depository (NPDepo) library. Although the addition of the identified enzyme inhibitor to the fungal culture did not inhibit trichothecene production, it can serve as a candidate lead compound in the development of a mycotoxin inhibitor that inactivates fungal defense mechanisms.
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