Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

(2014) Fumi Takahashi-Yanaga et al.   BIOCHEMICAL PHARMACOLOGY

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

(2014) Kilian V. M. Huber et al.   NATURE

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

8-oxoguanine causes spontaneous de novo germline mutations in mice

(2014) Mizuki Ohno et al.   Scientific Reports

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

(2012) Zijing Sheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype

(2012) Flandiana Yogianti et al.   MUTAGENESIS

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis

(2011) Sugako Oka et al.   CANCER SCIENCE

OXIDATIVE STRESS-INDUCED TUMORIGENESIS IN THE SMALL INTESTINES OF DNA REPAIR-DEFICIENT MICE

(2011) Teruhisa Tsuzuki et al.   HEALTH PHYSICS

MUTYH-associated polyposis (MAP)

(2010) Maartje Nielsen et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

DNA polymerases involved in the incorporation of oxidized nucleotides into DNA: Their efficiency and template base preference

(2010) Atsushi Katafuchi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

(2009) P. Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

(2008) Sugako Oka et al.   EMBO JOURNAL

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase   replication fidelity

(2008) Z. F. Pursell et al.   NUCLEIC ACIDS RESEARCH

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration

(2008) Gabriele De Luca et al.   PLoS Genetics

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death

(2007) Junji Ichikawa et al.   DNA REPAIR