Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1

Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation

(2010) Poulomi Acharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver Cytochrome P450 3A Ubiquitinationin Vivoby gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases

(2010) Sung-Mi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine Residues in the Cytosolic Tail of the T-cell Antigen Receptor α-Chain Mediate Ubiquitination and Endoplasmic Reticulum-associated Degradation of the Unassembled Protein

(2010) Shuhei Ishikura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Heme-Regulated Inhibitor (HRI) Eukaryotic Initiation Factor 2  Kinase: A Protagonist of Heme-Mediated Translational Control of CYP2B Enzymes and a Modulator of Basal Endoplasmic Reticulum Stress Tone

(2010) P. Acharya et al.   MOLECULAR PHARMACOLOGY

Prediction of Human Drug-Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator

(2009) L. Xu et al.   DRUG METABOLISM AND DISPOSITION

C Terminus of Hsc70-interacting Protein Promotes Smooth Muscle Cell Proliferation and Survival through Ubiquitin-mediated Degradation of FoxO1

(2009) Fang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic CYP3A Suppression by High Concentrations of Proteasomal Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction, Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation Factor 2  (eIF2 )-Kinase (PERK) and General Control Nonderepressible-2 eIF2  Kinase (GCN2), and Global Translational Shutoff

(2009) P. Acharya et al.   MOLECULAR PHARMACOLOGY

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

(2008) Michael K. Pabarcus et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

(2008) Jiansong Yang et al.   CURRENT DRUG METABOLISM

Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine

(2008) R. E. Pearce et al.   DRUG METABOLISM AND DISPOSITION

SCFFbxw7/hCdc4 targets cyclin E2 for ubiquitin-dependent proteolysis

(2008) Kathleen Klotz et al.   EXPERIMENTAL CELL RESEARCH

SCFCdc4 acts antagonistically to the PGC-1  transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

(2008) B. L. Olson et al.   GENES & DEVELOPMENT

A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation

(2008) YongQiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human Cytochrome P-450 2E1

(2008) Patrick R. Porubsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry

(2008) Gorden Redlich et al.   JOURNAL OF PROTEOME RESEARCH

In-depth Analysis of Tandem Mass Spectrometry Data from Disparate Instrument Types

(2008) Robert J. Chalkley et al.   MOLECULAR & CELLULAR PROTEOMICS

Ability of CK2β to selectively regulate cellular protein kinases

(2008) Birgitte B. Olsen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: A quantitative proteomic analysis

(2008) J. A. J. Steen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA