Usnic acid is a novel Pim-1 inhibitor with the abilities of inhibiting growth and inducing apoptosis in human myeloid leukemia cells

Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors

(2016) Yin-Bo Fan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding

(2015) James E. Beggs et al.   BIOCHEMICAL JOURNAL

p27 Kip1 signaling: Transcriptional and post-translational regulation

(2015) Su Su Thae Hnit et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Novel C-4 Heteroaryl 13-cis-Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in Mice

(2015) Hannah W. Mbatia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Review of the biological properties and toxicity of usnic acid

(2015) A. A. S. Araújo et al.   NATURAL PRODUCT RESEARCH

Targeting the Pim kinases in multiple myeloma

(2015) N A Keane et al.   Blood Cancer Journal

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety

(2015) Xuan Zhao et al.   Oncotarget

Targeting Mnks for Cancer Therapy

(2015) Jinqiang Hou et al.   Oncotarget

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines

(2015) Senthilmurugan Ramalingam et al.   Oncotarget

Pim kinases in hematological malignancies: where are we now and where are we going?

(2014) Patrizia Mondello et al.   Journal of Hematology & Oncology

Lichen Secondary Metabolites in Flavocetraria cucullata Exhibit Anti-Cancer Effects on Human Cancer Cells through the Induction of Apoptosis and Suppression of Tumorigenic Potentials

(2014) Thanh Thi Nguyen et al.   PLoS One

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

(2013) J. K. Altman et al.   BLOOD

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

(2013) E. K. Keeton et al.   BLOOD

Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E-BP1, eIF4E, and the mRNA 5′ cap

(2013) Anna Modrak-Wojcik et al.   FEBS LETTERS

Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

(2013) S. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

(2012) S. P. Glaser et al.   GENES & DEVELOPMENT

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioactive metabolites from Phoma species, an endophytic fungus from the Chinese medicinal plant Arisaema erubescens

(2011) Li-Wei Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

(2011) B. W. Konicek et al.   CANCER RESEARCH

Bcl-xL Is a Dominant Antiapoptotic Protein that Inhibits Homoharringtonine-Induced Apoptosis in Leukemia Cells

(2011) S. Yin et al.   MOLECULAR PHARMACOLOGY

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

(2010) Carmen Blanco-Aparicio et al.   CANCER LETTERS

Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid

(2010) M. Bačkorová et al.   TOXICOLOGY IN VITRO

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH

Inhibition of Polysome Assembly Enhances Imatinib Activity against Chronic Myelogenous Leukemia and Overcomes Imatinib Resistance

(2008) M. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY