Pim kinases in hematological malignancies: where are we now and where are we going?
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pim kinases in hematological malignancies: where are we now and where are we going?
Authors
Keywords
Pim kinases, Target therapy, Hematologic malignancies, Pim inhibitors
Journal
Journal of Hematology & Oncology
Volume 7, Issue 1, Pages -
Publisher
Springer Nature
Online
2014-12-10
DOI
10.1186/s13045-014-0095-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration
- (2014) Antoine Boudot et al. BMC CANCER
- PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways
- (2014) Koremu Meja et al. BRITISH JOURNAL OF HAEMATOLOGY
- Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
- (2014) P. D. Garcia et al. CLINICAL CANCER RESEARCH
- Chromosome Instability Underlies Hematopoietic Stem Cell Dysfunction and Lymphoid Neoplasia Associated with Impaired Fbw7-Mediated Cyclin E Regulation
- (2014) K. T. Siu et al. MOLECULAR AND CELLULAR BIOLOGY
- The Pim-1 Protein Kinase Is an Important Regulator of MET Receptor Tyrosine Kinase Levels and Signaling
- (2014) B. Cen et al. MOLECULAR AND CELLULAR BIOLOGY
- PIM Kinases Are Essential for Chronic Lymphocytic Leukemia Cell Survival (PIM2/3) and CXCR4-Mediated Microenvironmental Interactions (PIM1)
- (2014) S. Decker et al. MOLECULAR CANCER THERAPEUTICS
- Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation
- (2013) Go J. Yoshida et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia
- (2013) E. K. Keeton et al. BLOOD
- Regulation of c-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression
- (2013) Linsey Reavie et al. CANCER CELL
- Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562
- (2012) Li Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases
- (2012) Les A. Dakin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells
- (2012) M.-A. Hospital et al. BLOOD
- Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma
- (2012) Q. Yang et al. BLOOD
- PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma
- (2012) L Brault et al. BRITISH JOURNAL OF CANCER
- Abstract 2826: Preclinical development of a Pim kinase inhibitor for cancer treatment
- (2012) Krzysztof Brzózka et al. CANCER RESEARCH
- Preservation of Myocardial Structure Is Enhanced by Pim-1 Engineering of Bone Marrow Cells
- (2012) Pearl Quijada et al. CIRCULATION RESEARCH
- PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas
- (2012) B. W. Baron et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells
- (2011) Mahandranauth A. Chetram et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma
- (2011) C. Gomez-Abad et al. BLOOD
- Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia
- (2011) L. S. Chen et al. BLOOD
- Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma
- (2011) Jonathan H. Schatz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling
- (2011) Kimberlee M. Fischer et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A potential therapeutic target for FLT3-ITD AML: PIM1 kinase
- (2011) Amir T. Fathi et al. LEUKEMIA RESEARCH
- Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity
- (2010) Jongchan Kim et al. BMC CANCER
- Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition
- (2010) Carmen Blanco-Aparicio et al. CANCER LETTERS
- Pim-2 phosphorylation of p21Cip1/WAF1 enhances its stability and inhibits cell proliferation in HCT116 cells
- (2010) Zeping Wang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
- (2010) Linsey Reavie et al. NATURE IMMUNOLOGY
- The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation
- (2009) Hoang Anh Vu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma
- (2009) Y.-W. Lin et al. BLOOD
- Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells
- (2009) L. S. Chen et al. BLOOD
- Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation
- (2009) Alessio Zippo et al. CELL
- Pim-1 controls NF-κB signalling by stabilizing RelA/p65
- (2009) K Nihira et al. CELL DEATH AND DIFFERENTIATION
- Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration
- (2009) Rebekka Grundler et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes
- (2009) S. M. Mumenthaler et al. MOLECULAR CANCER THERAPEUTICS
- Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells
- (2009) Z. Beharry et al. MOLECULAR CANCER THERAPEUTICS
- PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis
- (2009) J J Gu et al. ONCOGENE
- The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes
- (2008) G. Wernig et al. BLOOD
- Malignant Transformation Initiated by Mll-AF9: Gene Dosage and Critical Target Cells
- (2008) Weili Chen et al. CANCER CELL
- Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels
- (2008) D. Morishita et al. CANCER RESEARCH
- Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal
- (2008) Nilesh Shah et al. EUROPEAN JOURNAL OF CANCER
- Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma
- (2008) Carol Hogan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cancer stem cells: implications for the progression and treatment of metastatic disease
- (2008) A.K Croker et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study
- (2008) Eric D. Hsi et al. LEUKEMIA & LYMPHOMA
- Pim kinase-dependent inhibition of c-Myc degradation
- (2008) Y Zhang et al. ONCOGENE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started