Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

(2011) B. W. Konicek et al.   CANCER RESEARCH

Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a–dependent neurite outgrowth

(2011) Yoshimi Endo Greer et al.   JOURNAL OF CELL BIOLOGY

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies

(2010) P. R. Hagner et al.   BLOOD

The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival

(2010) Matthew J. Wheater et al.   CANCER BIOLOGY & THERAPY

MNK, EIF4E and targeting translation for therapy

(2010) Ricardo L.A. Silva et al.   CELL CYCLE

Targeting the BCR-ABL Signaling Pathway in Therapy-Resistant Philadelphia Chromosome-Positive Leukemia

(2010) T. O'Hare et al.   CLINICAL CANCER RESEARCH

Chronic myeloid leukemia: mechanisms of blastic transformation

(2010) Danilo Perrotti et al.   JOURNAL OF CLINICAL INVESTIGATION

Mnk Mediates Integrin  6 4-Dependent eIF4E Phosphorylation and Translation of VEGF mRNA

(2010) N. L. Korneeva et al.   MOLECULAR CANCER RESEARCH

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development

(2010) T. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

(2010) L. Furic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mnk earmarks eIF4E for cancer therapy

(2010) N. Hay   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia

(2009) A Hochhaus et al.   LEUKEMIA

Glycogen synthase kinase 3  missplicing contributes to leukemia stem cell generation

(2009) A. E. Abrahamsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular biology of bcr-abl1-positive chronic myeloid leukemia

(2008) A. Quintas-Cardama et al.   BLOOD

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

(2008) Andrea Bianchini et al.   CARCINOGENESIS

The eIF4E RNA regulon promotes the Akt signaling pathway

(2008) Biljana Culjkovic et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Polysome Assembly Enhances Imatinib Activity against Chronic Myelogenous Leukemia and Overcomes Imatinib Resistance

(2008) M. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Many roads lead to oncogene-induced senescence

(2008) S Courtois-Cox et al.   ONCOGENE