Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances

FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease

(2018) Nicola Martinelli et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Long-chain n-3 PUFA against breast and prostate cancer: Which are the appropriate doses for intervention studies in animals and humans?

(2015) Elena Fasano et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells

(2015) Hui Gyu Park et al.   FASEB JOURNAL

Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity

(2014) Yi-Da Wang et al.   FISH & SHELLFISH IMMUNOLOGY

Unsaturated Fatty Acids, Desaturases, and Human Health

(2014) Hyungjae Lee et al.   JOURNAL OF MEDICINAL FOOD

ω3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use

(2013) Mingxuan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cloning and functional analysis of HpFAD2 and HpFAD3 genes encoding Δ12- and Δ15-fatty acid desaturases in Hansenula polymorpha

(2013) Juthaporn Sangwallek et al.   GENE

Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

(2013) Harini Sampath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-vaccenate is Δ13-desaturated by FADS3 in rodents

(2013) Vincent Rioux et al.   JOURNAL OF LIPID RESEARCH

Reconstitution of EPA and DHA biosynthesis in Arabidopsis: Iterative metabolic engineering for the synthesis of n−3 LC-PUFAs in transgenic plants

(2013) Noemi Ruiz-Lopez et al.   METABOLIC ENGINEERING

Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites

(2012) Karen A. Massey et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of a novel C22-∆4-producing docosahexaenoic acid (DHA) specific polyunsaturated fatty acid desaturase gene from Isochrysis galbana and its expression in Saccharomyces cerevisiae

(2012) Tonglei Shi et al.   BIOTECHNOLOGY LETTERS

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

(2012) Philip C. Calder   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Therapeutic implications of disorders of cell death signalling: membranes, micro-environment, and eicosanoid and docosanoid metabolism

(2012) J Davidson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants

(2012) N. Ruiz-Lopez et al.   JOURNAL OF EXPERIMENTAL BOTANY

Identification and evaluation of ω-3 fatty acid desaturase genes for hyperfortifying α-linolenic acid in transgenic rice seed

(2012) Hua Liang Liu et al.   JOURNAL OF EXPERIMENTAL BOTANY

Analysis of Δ12-fatty acid desaturase function revealed that two distinct pathways are active for the synthesis of PUFAs inT. aureumATCC 34304

(2012) Takanori Matsuda et al.   JOURNAL OF LIPID RESEARCH

A novelFADS1isoform potentiatesFADS2-mediated production of eicosanoid precursor fatty acids

(2012) Woo Jung Park et al.   JOURNAL OF LIPID RESEARCH

Characterization of an arachidonic acid-deficient (Fads1knockout) mouse model

(2012) Yang-Yi Fan et al.   JOURNAL OF LIPID RESEARCH

Marine N-3 Polyunsaturated Fatty Acids Are Inversely Associated with Risk of Type 2 Diabetes in Asians: A Systematic Review and Meta-Analysis

(2012) Ju-Sheng Zheng et al.   PLoS One

Insertion–deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin

(2012) Holly T. Reardon et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Eicosanoids in skin inflammation

(2012) Anna Nicolaou   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome

(2011) Susan Sergeant et al.   BRITISH JOURNAL OF NUTRITION

Global Gene Expression Profiles of Subcutaneous Adipose and Muscle From Glucose-Tolerant, Insulin-Sensitive, and Insulin-Resistant Individuals Matched for BMI

(2011) Steven C. Elbein et al.   DIABETES

Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk

(2011) Artemis P Simopoulos   EXPERIMENTAL BIOLOGY AND MEDICINE

Omega-3 fatty acids: a potential booster for tamoxifen therapy?

(2011) Lucas Tadeu Bidinotto et al.   Expert Review of Anticancer Therapy

Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer

(2011) A J Cockbain et al.   GUT

Caenorhabditis elegansΔ12-Desaturase FAT-2 Is a Bifunctional Desaturase Able to Desaturate a Diverse Range of Fatty Acid Substrates at the Δ12 and Δ15 Positions

(2011) Xue-Rong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Front-end Desaturase: Structure, Function, Evolution and Biotechnological Use

(2011) Dauenpen Meesapyodsuk et al.   LIPIDS

Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study

(2011) Oh Yoen Kim et al.   Nutrition & Metabolism

FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids

(2011) Woo Jung Park et al.   PLoS One

Regulation of inflammation in cancer by eicosanoids

(2011) Emily R. Greene et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds

(2011) Cory L. Nykiforuk et al.   TRANSGENIC RESEARCH

Cloning and Functional Identification of Delta5 Fatty Acid Desaturase Gene and Its 5′-Upstream Region from Marine Fungus Thraustochytrium sp. FJN-10

(2010) Jian-Zhong Huang et al.   MARINE BIOTECHNOLOGY

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Vertebrate fatty acyl desaturase with  4 activity

(2010) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis and bioavailability of long-chain polyunsaturated fatty acids in non-alcoholic fatty liver disease

(2010) Juan G. Gormaz et al.   PROGRESS IN LIPID RESEARCH

Establishment of Agrobacterium tumefaciens-Mediated Transformation of an Oleaginous Fungus, Mortierella alpina 1S-4, and Its Application for Eicosapentaenoic Acid Producer Breeding

(2009) A. Ando et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing

(2009) Woo Jung Park et al.   GENE

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

(2009) Chad K. Stroud et al.   JOURNAL OF LIPID RESEARCH

An alternate pathway to long-chain polyunsaturates: theFADS2gene product Δ8-desaturates 20:2n-6 and 20:3n-3

(2009) Woo Jung Park et al.   JOURNAL OF LIPID RESEARCH

Alternative splicing generates a novel FADS2 alternative transcript in baboons

(2009) Woo Jung Park et al.   MOLECULAR BIOLOGY REPORTS

The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of ‘heart-healthy’ omega-3 fatty acids

(2009) Noemí Ruiz-López et al.   PLANT BIOTECHNOLOGY JOURNAL

An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids

(2009) Mónica Venegas-Calerón et al.   PROGRESS IN LIPID RESEARCH

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study

(2009) Toshiko Tanaka et al.   PLoS Genetics

A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia

(2009) Christopher L. Plaisier et al.   PLoS Genetics

Substrate Specificity and Regioselectivity of Δ12 and ω3 Fatty Acid Desaturases fromSaccharomyces kluyveri

(2008) Takahiro OURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Reduced Colitis-Associated Colon Cancer in Fat-1 (n-3 Fatty Acid Desaturase) Transgenic Mice

(2008) Q. Jia et al.   CANCER RESEARCH

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

(2008) Artemis P. Simopoulos   EXPERIMENTAL BIOLOGY AND MEDICINE

Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n-6) and (n-3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation

(2008) Lin Xie et al.   JOURNAL OF NUTRITION

Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3β phosphorylation

(2008) Yi Lu et al.   MOLECULAR CANCER THERAPEUTICS

Identification and characterization of a novel yeast ω3-fatty acid desaturase acting on long-chain n-6 fatty acid substrates fromPichia pastoris

(2007) Xinxin Zhang et al.   YEAST