Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
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Title
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
Authors
Keywords
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Journal
Blood Cancer Journal
Volume 6, Issue 11, Pages e492-e492
Publisher
Springer Nature
Online
2016-11-04
DOI
10.1038/bcj.2016.93
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Note: Only part of the references are listed.- Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors
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- (2015) P. Jain et al. BLOOD
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- (2015) Kasyapa Chitta et al. BRITISH JOURNAL OF HAEMATOLOGY
- Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15
- (2015) Xin Wang et al. Chemical Biology & Drug Design
- MYD88 Mutations and Response to Ibrutinib in Waldenström's Macroglobulinemia
- (2015) Steven P. Treon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia
- (2015) Steven P. Treon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells
- (2015) Rachel Isaksson Vogel et al. Oncotarget
- CXCR7-dependent angiogenic mononuclear cell trafficking regulates tumor progression in multiple myeloma
- (2014) A. K. Azab et al. BLOOD
- CXCR4WHIM-like frameshift and nonsense mutations promote ibrutinib resistance but do not supplantMYD88L265P-directed survival signalling in Waldenström macroglobulinaemia cells
- (2014) Yang Cao et al. BRITISH JOURNAL OF HAEMATOLOGY
- Ibrutinib Treatment of CLL: The Cancer Fights Back
- (2014) Ryan M. Young et al. CANCER CELL
- Regulation of TRAIL-Receptor Expression by the Ubiquitin-Proteasome System
- (2014) Dhifaf Sarhan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The WHIM-like CXCR4S338X somatic mutation activates AKT and ERK and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia
- (2014) Y Cao et al. LEUKEMIA
- Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib
- (2014) Jennifer A. Woyach et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ibrutinib Resistance in Chronic Lymphocytic Leukemia
- (2014) Richard R. Furman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
- (2014) G. R. Pathare et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia
- (2014) K Chitta et al. Blood Cancer Journal
- Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S BTK Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma
- (2014) D. Chiron et al. Cancer Discovery
- Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress
- (2013) Slavica Brnjic et al. ANTIOXIDANTS & REDOX SIGNALING
- A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
- (2013) Z. Tian et al. BLOOD
- AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia
- (2013) Aneel Paulus et al. BRITISH JOURNAL OF HAEMATOLOGY
- A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells
- (2013) Dhifaf Sarhan et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Proteasome Inhibitor Therapy for Waldenström's Macroglobulinemia
- (2013) Meletios A. Dimopoulos et al. Clinical Lymphoma Myeloma & Leukemia
- Proapoptotic effects of the novel proteasome inhibitor b-AP15 on multiple myeloma cells and natural killer cells
- (2013) Xiaoli Feng et al. EXPERIMENTAL HEMATOLOGY
- Neem leaf extract induces cell death by apoptosis and autophagy in B-chronic lymphocytic leukemia cells
- (2013) Kasyapa S. Chitta et al. LEUKEMIA & LYMPHOMA
- Targeting pathological B cell receptor signalling in lymphoid malignancies
- (2013) Ryan M. Young et al. NATURE REVIEWS DRUG DISCOVERY
- Proteasome deubiquitinases as novel targets for cancer therapy
- (2012) Pádraig D’Arcy et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute – Waldenström Macroglobulinemia 1
- (2012) Kasyapa S. Chitta et al. LEUKEMIA & LYMPHOMA
- Would the real Waldenström cell line please stand up?
- (2012) Hans G. Drexler et al. LEUKEMIA & LYMPHOMA
- Waldenström macroglobulinemia: a Surveillance, Epidemiology, and End Results database review from 1988 to 2005
- (2012) Jeevan Sekhar et al. LEUKEMIA & LYMPHOMA
- Proteasome Inhibition and Combination Therapy for Non-Hodgkin's Lymphoma: From Bench to Bedside
- (2012) A. R. Mato et al. ONCOLOGIST
- Effect of ubiquitin carboxy-terminal hydrolase 37 on apoptotic in A549 cells
- (2011) Zhiwei Chen et al. CELL BIOCHEMISTRY AND FUNCTION
- Inhibition of proteasome deubiquitinating activity as a new cancer therapy
- (2011) Pádraig D'Arcy et al. NATURE MEDICINE
- Deubiquitinases in cancer: new functions and therapeutic options
- (2011) J M Fraile et al. ONCOGENE
- Phase II Trial of Weekly Bortezomib in Combination With Rituximab in Relapsed or Relapsed and Refractory Waldenström Macroglobulinemia
- (2010) Irene M. Ghobrial et al. JOURNAL OF CLINICAL ONCOLOGY
- Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data
- (2010) Ilya Kupershmidt et al. PLoS One
- Vascular complications after splenectomy for hematologic disorders
- (2009) S. E. Crary et al. BLOOD
- SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia
- (2008) H. T. Ngo et al. BLOOD
- Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF- B
- (2008) L. Yu et al. BLOOD
- Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation
- (2008) Marjelo A. Mines et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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