Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

Molecular Pathways: Translational Potential of Deubiquitinases as Drug Targets

(2014) P. D'Arcy et al.   CLINICAL CANCER RESEARCH

Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer In Vitro and In Vivo via Exacerbating Unfolded Protein Responses

(2014) K. Coughlin et al.   CLINICAL CANCER RESEARCH

Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems

(2014) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

(2013) Slavica Brnjic et al.   ANTIOXIDANTS & REDOX SIGNALING

Deubiquitinase Inhibition of 19S Regulatory Particles by 4-Arylidene Curcumin Analog AC17 Causes NF- B Inhibition and p53 Reactivation in Human Lung Cancer Cells

(2013) B. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

Motion of transfer RNA from the A/T state into the A-site using docking and simulations

(2013) Thomas Caulfield et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes

(2012) Olga A. Issaenko et al.   CELL CYCLE

Molecular dynamics simulations of human DNA methyltransferase 3B with selective inhibitor nanaomycin A

(2011) Thomas Caulfield et al.   JOURNAL OF STRUCTURAL BIOLOGY

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

Structural characterization of human Uch37

(2011) Sethe E. Burgie et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Novel Method for Generating Structure-Based Pharmacophores Using Energetic Analysis

(2009) Noeris K. Salam et al.   Journal of Chemical Information and Modeling

Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation

(2009) Kathryn Loving et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The fluorometric microculture cytotoxicity assay

(2008) Elin Lindhagen et al.   Nature Protocols

Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities

(2008) Benjamin Nicholson et al.   PROTEIN SCIENCE