New roles for old pathways? A circuitous relationship between reactive oxygen species and cyclo-oxygenase in hypertension

Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat

(2013) Kathryn M. Spitler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endoplasmic Reticulum Stress and Nox-Mediated Reactive Oxygen Species Signaling in the Peripheral Vasculature: Potential Role in Hypertension

(2013) Celio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

The Roles of Cytochrome P450 in Ischemic Heart Disease

(2013) Motohiko Sato et al.   CURRENT DRUG METABOLISM

Long-Term Inhibition of Xanthine Oxidase by Febuxostat Does Not Decrease Blood Pressure in Deoxycorticosterone Acetate (DOCA)-Salt Hypertensive Rats

(2013) Theodora Szasz et al.   PLoS One

Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies

(2012) Augusto C. Montezano et al.   ANNALS OF MEDICINE

Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension

(2012) Sonia Martínez-Revelles et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Inactivation of the E-Prostanoid 3 Receptor Attenuates the Angiotensin II Pressor Response via Decreasing Arterial Contractility

(2012) Lihong Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endoplasmic Reticulum Stress Is Involved in Cardiac Damage and Vascular Endothelial Dysfunction in Hypertensive Mice

(2012) Modar Kassan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes

(2012) Zafar Rasheed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pioglitazone treatment increases COX-2-derived prostacyclin production and reduces oxidative stress in hypertensive rats: role in vascular function

(2012) Raquel Hernanz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Whole-cell and nuclear NADPH oxidases levels and distribution in human endocardial endothelial, vascular smooth muscle, and vascular endothelial cells

(2012) Lena Ahmarani et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Aquaporin 1, Nox1, and Ask1 mediate oxidant-induced smooth muscle cell hypertrophy

(2012) Imad Al Ghouleh et al.   CARDIOVASCULAR RESEARCH

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

Activation of thromboxane receptor modulates interleukin-1β-induced monocyte adhesion―A novel role of Nox1

(2012) Hossein Bayat et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonaryhypertension

(2012) Olga Rafikova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uric Acid Reduction Rectifies Prehypertension in Obese Adolescents

(2012) Beth Soletsky et al.   HYPERTENSION

Angiotensin II–Dependent Hypertension Requires Cyclooxygenase 1–Derived Prostaglandin E 2 and EP 1 Receptor Signaling in the Subfornical Organ of the Brain

(2012) Xian Cao et al.   HYPERTENSION

Thromboxane Receptors in Smooth Muscle Promote Hypertension, Vascular Remodeling, and Sudden Death

(2012) Matthew A. Sparks et al.   HYPERTENSION

Low-Dose Dextromethorphan, a NADPH Oxidase Inhibitor, Reduces Blood Pressure and Enhances Vascular Protection in Experimental Hypertension

(2012) Tao-Cheng Wu et al.   PLoS One

Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice

(2012) Y. Yu et al.   Science Translational Medicine

Targeting NADPH oxidases in vascular pharmacology

(2012) Agata Schramm et al.   VASCULAR PHARMACOLOGY

Cyclo-Oxygenase-2 Knockout Genotype in Mice Is Associated With Blunted Angiotensin II-Induced Oxidative Stress and Hypertension

(2011) R. Wu et al.   AMERICAN JOURNAL OF HYPERTENSION

Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide Production

(2011) Feng Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Endothelial Function by Mitochondrial Reactive Oxygen Species

(2011) Michael E. Widlansky et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress-Dependent Cyclooxygenase-2-Derived Prostaglandin F2α Impairs Endothelial Function in Renovascular Hypertensive Rats

(2011) Xiao Yu Tian et al.   ANTIOXIDANTS & REDOX SIGNALING

Pivotal Role of Protein Kinase C δ in Angiotensin II–Induced Endothelial Cyclooxygenase-2 Expression

(2011) Siu Ling Wong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Small Artery Remodelling in Hypertension

(2011) Michael J. Mulvany   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4

(2011) Hyun Kook Cho et al.   BIOCHEMICAL JOURNAL

Endothelium-mediated control of vascular tone: COX-1 and COX-2 products

(2011) Michel Félétou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microsomal Prostaglandin E 2 Synthase-1 Modulates the Response to Vascular Injury

(2011) Miao Wang et al.   CIRCULATION

Resistance artery mechanics and composition in angiotensin II-infused mice: effects of cyclooxygenase-1 inhibition

(2011) Agostino Virdis et al.   EUROPEAN HEART JOURNAL

NADPH oxidase 1 mediates upregulation of thromboxane A2 synthase in human vascular smooth muscle cells: Inhibition with iloprost

(2011) Saima Muzaffar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase

(2011) Silvia S. Barbieri et al.   FASEB JOURNAL

Reciprocal regulation of NADPH oxidases and the cyclooxygenase-2 pathway

(2011) Patricia Sancho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and endothelial dysfunction in hypertension

(2011) Eberhard Schulz et al.   HYPERTENSION RESEARCH

Structural abnormalities of small resistance arteries in essential hypertension

(2011) Damiano Rizzoni et al.   Internal and Emergency Medicine

Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress

(2011) Angela Martín et al.   JOURNAL OF HYPERTENSION

Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species

(2011) Kyung-Jin Cho et al.   MOLECULES AND CELLS

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: A novel target for antihypertensive agents

(2011) Kafait U. Malik et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

(2010) Anna E. Dikalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Use of Nonsteroidal Anti-Inflammatory Drugs in Patients With Cardiovascular Disease

(2010) Muhammad Amer et al.   Cardiology in Review

Bone Morphogenic Protein-4 Impairs Endothelial Function Through Oxidative Stress–Dependent Cyclooxygenase-2 Upregulation

(2010) Wing Tak Wong et al.   CIRCULATION RESEARCH

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Endothelium-derived Vasoactive Factors and Hypertension: Possible Roles in Pathogenesis and as Treatment Targets

(2010) Michel Félétou et al.   CURRENT HYPERTENSION REPORTS

Role of extracellular matrix in vascular remodeling of hypertension

(2010) Ana M Briones et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Cyclooxygenase 1–Derived Prostaglandin E 2 and EP1 Receptors Are Required for the Cerebrovascular Dysfunction Induced by Angiotensin II

(2010) Carmen Capone et al.   HYPERTENSION

mPGES-1 Protects Against DOCA-Salt Hypertension via Inhibition of Oxidative Stress or Stimulation of NO/cGMP

(2010) Zhanjun Jia et al.   HYPERTENSION

EP1c Times for Angiotensin

(2010) Ricardo A. Pena-Silva et al.   HYPERTENSION

Reactive oxygen species and vascular biology: implications in human hypertension

(2010) Rhian M Touyz et al.   HYPERTENSION RESEARCH

Allopurinol Does Not Decrease Blood Pressure or Prevent the Development of Hypertension in the Deoxycorticosterone Acetate-Salt Rat Model

(2010) Theodora Szasz et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli

(2010) María Galán et al.   JOURNAL OF HYPERTENSION

Selenium inhibits high glucose-induced cyclooxygenase-2 and P-selectin expression in vascular endothelial cells

(2010) Yan-Bo Li et al.   MOLECULAR BIOLOGY REPORTS

Redox regulation of Nox proteins

(2010) Srikanth Pendyala et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors

(2009) Michel Félétou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased xanthine oxidase activity in idiopathic pulmonary arterial hypertension

(2009) S. Spiekermann et al.   EUROPEAN RESPIRATORY JOURNAL

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Attenuation of Angiotensin II–Induced Vascular Dysfunction and Hypertension by Overexpression of Thioredoxin 2

(2009) Julian D. Widder et al.   HYPERTENSION

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

Atorvastatin Prevents Angiotensin II–Induced Vascular Remodeling and Oxidative Stress

(2009) Ana M. Briones et al.   HYPERTENSION

Atorvastatin Prevents Endothelial Dysfunction in Mesenteric Arteries From Spontaneously Hypertensive Rats

(2009) Agostino Virdis et al.   HYPERTENSION

Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols

(2009) Modou O. Kane et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The effect of tempol on endothelium-dependent vasodilatation and blood pressure

(2009) Ulf Simonsen et al.   PHARMACOLOGY & THERAPEUTICS

Aging and prostacyclin responses in aorta and platelets from WKY and SHR rats

(2008) Elodie Gomez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats

(2008) Emilie C. Viel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction

(2008) Thomas Münzel et al.   ANNALS OF MEDICINE

Thioredoxin in Vascular Biology: Role in Hypertension

(2008) Talin Ebrahimian et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric Oxide, Tetrahydrobiopterin, Oxidative Stress, and Endothelial Dysfunction in Hypertension

(2008) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxynitrite as regulator of vascular prostanoid synthesis

(2008) Stefan Schildknecht et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate

(2008) S Muzaffar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aldosterone induces endothelial dysfunction in resistance arteries from normotensive and hypertensive rats by increasing thromboxane A2and prostacyclin

(2008) F E Xavier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microsomal Prostaglandin E Synthase-1 Deletion Suppresses Oxidative Stress and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

(2008) Miao Wang et al.   CIRCULATION

Endothelium-Specific GTP Cyclohydrolase I Overexpression Attenuates Blood Pressure Progression in Salt-Sensitive Low-Renin Hypertension

(2008) Yan-Hua Du et al.   CIRCULATION

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

(2008) S DIKALOV et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microsomal Prostaglandin Synthase-1–Derived Prostaglandin E 2 Protects Against Angiotensin II–Induced Hypertension via Inhibition of Oxidative Stress

(2008) Zhanjun Jia et al.   HYPERTENSION

Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension

(2008) Daniel I. Feig et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tetrahydrobiopterin: a novel antihypertensive therapy

(2008) M Porkert et al.   JOURNAL OF HUMAN HYPERTENSION

p38 MAPK contributes to angiotensin II-induced COX-2 expression in aortic fibroblasts from normotensive and hypertensive rats

(2008) Amada E Beltrán et al.   JOURNAL OF HYPERTENSION

Hypertension Increases Contractile Responses to Hydrogen Peroxide in Resistance Arteries through Increased Thromboxane A2, Ca2+, and Superoxide Anion Levels

(2008) A. B. Garcia-Redondo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Thromboxane A2: Physiology/pathophysiology, cellular signal transduction and pharmacology

(2008) Norimichi Nakahata   PHARMACOLOGY & THERAPEUTICS

Role of NADPH oxidase and iNOS in vasoconstrictor responses of vessels from hypertensive and normotensive rats

(2007) Y Álvarez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells

(2007) Hong Peng et al.   PEPTIDES