Journal
CHEMPLUSCHEM
Volume 80, Issue 6, Pages 938-943Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201402435
Keywords
cancer stem cells; click chemistry; docking; hedgehog pathway; vismodegib
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Funding
- COST Actions [CM 1106] Funding Source: Medline
- OpenEye Free Academic Licensing Program Funding Source: Medline
- PRIN 2012 Funding Source: Medline
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The design and the preparation of a small library of 1,4-diphenyl-1,2,3-triazole derivatives is reported, with the aim to obtain a new class of Hedgehog pathway inhibitors. The smoothened protein is part of the hedgehog signaling pathway that is inhibited by the lead compound Vismodegib. Based on molecular modeling simulations, seven triazole derivatives of Vismodegib are synthesized and their biological effect on different endothelial, cancer, and cancer stem cell lines is reported.
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