Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling

(2009) Tommaso Cupido et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A small molecule that binds Hedgehog and blocks its signaling in human cells

(2009) Benjamin Z Stanton et al.   Nature Chemical Biology

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana

(2008) Midori A. Arai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway

(2008) Stefan Peukert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation

(2008) Christine Dierks et al.   CANCER CELL

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists

(2008) Martin R. Tremblay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent Inhibitors of the Hedgehog Signaling Pathway

(2008) Shirley A. Brunton et al.   JOURNAL OF MEDICINAL CHEMISTRY

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

 -Arrestin-Mediated Localization of Smoothened to the Primary Cilium

(2008) J. J. Kovacs et al.   SCIENCE