Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products

Discovery and Evaluation of Novel Inhibitors of Mycobacterium Protein Tyrosine Phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic Acid Scaffold

(2013) Yantao He et al.   JOURNAL OF MEDICINAL CHEMISTRY

Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

(2012) Hugo Lachance et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development

(2012) Dennis Wong et al.   TRENDS IN MICROBIOLOGY

Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein

(2012) Mattia Mori et al.   VIRUS RESEARCH

Synthesis, Biological Evaluation, And Molecular Modeling of Chalcone Derivatives As Potent Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatases (PtpA and PtpB)

(2011) Louise Domeneghini Chiaradia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B

(2011) Viktor V. Vintonyak et al.   TETRAHEDRON

Sulfonyl-hydrazones of cyclic imides derivatives as potent inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB)

(2011) Kely Navakoski de Oliveira et al.   MedChemComm

Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: Kinetics, molecular modeling, toxicity and effect on growth

(2010) Alessandra Mascarello et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mycobacterium tuberculosis tyrosine phosphatase A (PtpA) activity is modulated by S-nitrosylation

(2010) Gabriela Ecco et al.   CHEMICAL COMMUNICATIONS

Predicting the Binding Mode of Known NCp7 Inhibitors To Facilitate the Design of Novel Modulators

(2010) Mattia Mori et al.   Journal of Chemical Information and Modeling

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

(2010) B. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The therapeutic potential of phosphatase inhibitors

(2009) Viktor V Vintonyak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages

(2009) Nicola J. Beresford et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA

(2008) Louise Domeneghini Chiaradia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein tyrosine phosphatases: structure-function relationships

(2008) Lydia Tabernero et al.   FEBS Journal

Protein tyrosine phosphatase PtpA is not required forMycobacterium tuberculosisgrowth in mice

(2008) Christoph Grundner et al.   FEMS MICROBIOLOGY LETTERS