The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents

PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data

(2015) Natalja Kurbatova et al.   PLoS One

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) progress to date and future plans

(2015) Charlotte M. Keenan et al.   Journal of Toxicologic Pathology

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Longevity, aging and rapamycin

(2014) Dan Ehninger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Integrating pathology into human disease modelling - how to eat the elephant

(2014) C. L. Scudamore   Disease Models & Mechanisms

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

(2014) H. A. Adissu et al.   Disease Models & Mechanisms

Rapamycin and Ageing: When, for How Long, and How Much?

(2014) Matt Kaeberlein   Journal of Genetics and Genomics

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Advances in Geroscience: Impact on Healthspan and Chronic Disease

(2014) J. B. Burch et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A simplified necropsy technique for mice: making the most of unscheduled deaths

(2014) Cheryl L Scudamore et al.   LABORATORY ANIMALS

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

The Future of Preclinical Animal Models in Pharmaceutical Discovery and Development

(2014) Jeffrey I. Everitt   TOXICOLOGIC PATHOLOGY

Right Ventricular Epicardial Fibrosis in Mice With Sternal Segment Dislocation

(2014) H. A. Adissu et al.   VETERINARY PATHOLOGY

Commentary

(2014) P. V. Turner et al.   VETERINARY PATHOLOGY

Identification of Genes Important for Cutaneous Function Revealed by a Large Scale Reverse Genetic Screen in the Mouse

(2014) Tia DiTommaso et al.   PLoS Genetics

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Preserving Youth: Does Rapamycin Deliver?

(2013) S. C. Johnson et al.   Science Translational Medicine

Society of Toxicologic Pathology Position Paper on Best Practices on Recovery Studies

(2013) Rick Perry et al.   TOXICOLOGIC PATHOLOGY

Regulatory Forum Commentary

(2013) Charlotte M. Keenan et al.   TOXICOLOGIC PATHOLOGY

Principles for Valid Histopathologic Scoring in Research

(2013) K. N. Gibson-Corley et al.   VETERINARY PATHOLOGY

The mouse pathology ontology, MPATH; structure and applications

(2013) Paul N Schofield et al.   Journal of Biomedical Semantics

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

A Single-Nucleotide Polymorphism in the Abcc6 Gene Associates with Connective Tissue Mineralization in Mice Similar to Targeted Models for Pseudoxanthoma Elasticum

(2012) Annerose Berndt et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pathobiology of Aging Mice and GEM

(2012) C. F. Brayton et al.   VETERINARY PATHOLOGY

Identification of Fat4 and Tsc22d1 as Novel Candidate Genes for Spontaneous Pulmonary Adenomas

(2011) A. Berndt et al.   CANCER RESEARCH

TOR in the immune system

(2011) Koichi Araki et al.   CURRENT OPINION IN CELL BIOLOGY

Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice

(2011) P. N. Schofield et al.   Disease Models & Mechanisms

Reduction of Age-Associated Pathology in Old Mice by Overexpression of Catalase in Mitochondria

(2011) P. M. Treuting et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Internet and Print Resources to Facilitate Pathology Analysis When Phenotyping Genetically Engineered Rodents

(2011) B. Bolon et al.   VETERINARY PATHOLOGY

Rapamycin Joins the Aging Fray: Maybe Ponce de Leon Visited Rapa Nui, not Florida

(2010) F. Sierra   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Role of mTOR Signaling in Controlling Mammalian Life Span: What a Fungicide Teaches Us About Longevity

(2010) Z. D. Sharp et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

International Recommendations for Training Future Toxicologic Pathologists Participating in Regulatory-type, Nonclinical Toxicity Studies

(2010) Brad Bolon (Chair) et al.   TOXICOLOGIC PATHOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Lifespan extension in genetically modified mice

(2009) Warren Ladiges et al.   AGING CELL

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

(2009) Rong Yuan et al.   AGING CELL

Healthspan, Translation, and New Outcomes for Animal Studies of Aging

(2009) J. L. Kirkland et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A Data-capture Tool for Mouse Pathology Phenotyping

(2009) B. A. Sundberg et al.   VETERINARY PATHOLOGY

Integrating mouse anatomy and pathology ontologies into a phenotyping database: Tools for data capture and training

(2008) John P. Sundberg et al.   MAMMALIAN GENOME

Do-it-yourself (DIY) pathology

(2008) Tan A Ince et al.   NATURE BIOTECHNOLOGY

Editorial: Best Pathology Practices in Research Using Genetically Engineered Mice

(2008) B. Bolon et al.   VETERINARY PATHOLOGY