Pigs in Toxicology

Unraveling the in vitro and in vivo metabolism of diacetoxyscirpenol in various animal species and human using ultrahigh-performance liquid chromatography-quadrupole/time-of-flight hybrid mass spectrometry

(2015) Shupeng Yang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Whole-genome resequencing analyses of five pig breeds, including Korean wild and native, and three European origin breeds

(2015) Jung-Woo Choi et al.   DNA RESEARCH

Organohalogens and their hydroxylated metabolites in the blood of pigs from an open waste dumping site in south India: Association with hepatic cytochrome P450

(2015) Hazuki Mizukawa et al.   ENVIRONMENTAL RESEARCH

Comparison of minipig, dog, monkey and human drug metabolism and disposition

(2015) Lars Dalgaard   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Differential expression ofCYB5Ain Chinese and European pig breeds due to genetic variations in the promoter region

(2014) Y. Bai et al.   ANIMAL GENETICS

Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

(2014) F. Oesch et al.   ARCHIVES OF TOXICOLOGY

Maternal dietary betaine supplementation modifies hepatic expression of cholesterol metabolic genes via epigenetic mechanisms in newborn piglets

(2014) Demin Cai et al.   BRITISH JOURNAL OF NUTRITION

Spontaneous Background Pathology in Göttingen Minipigs

(2014) Gitte Jeppesen et al.   TOXICOLOGIC PATHOLOGY

Pigs fed camelina meal increase hepatic gene expression of cytochrome 8b1, aldehyde dehydrogenase, and thiosulfate transferase

(2014) William Jon Meadus et al.   Journal of Animal Science and Biotechnology

Xenobiotic Metabolizing Cytochrome P450 in Pig, a Promising Animal Model

(2013) Emanuela Puccinelli et al.   CURRENT DRUG METABOLISM

Regulation of 3β-hydroxysteroid dehydrogenase and sulphotransferase 2A1 gene expression in primary porcine hepatocytes by selected sex-steroids and plant secondary metabolites from chicory (Cichorium intybus L.) and wormwood (Artemisia sp.)

(2013) Martin Krøyer Rasmussen et al.   GENE

Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development

(2013) Jessica J. Vamathevan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs

(2013) Emanuela Puccinelli et al.   XENOBIOTICA

The roles of different porcine cytochrome P450 enzymes and cytochrome b5A in skatole metabolism

(2012) P. Wiercinska et al.   Animal

Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs

(2012) Misaki Kojima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A gene expression atlas of the domestic pig

(2012) Tom C Freeman et al.   BMC BIOLOGY

Animal models of toxicology testing: the role of pigs

(2012) Kristi L Helke et al.   Expert Opinion on Drug Metabolism & Toxicology

Dried chicory root modifies the activity and expression of porcine hepatic CYP3A but not 2C – Effect of in vitro and in vivo exposure

(2012) Martin Krøyer Rasmussen et al.   FOOD AND CHEMICAL TOXICOLOGY

Maternal low-protein diet causes epigenetic deregulation of HMGCR and CYP7α1 in the liver of weaning piglets

(2012) Rihua Cong et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs

(2012) Masayuki Mogi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Analyses of pig genomes provide insight into porcine demography and evolution

(2012) Martien A. M. Groenen et al.   NATURE

A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation

(2012) Claudia Suenderhauf et al.   PHARMACEUTICAL RESEARCH

In vitroandIn vivoAssociation of Porcine Hepatic Cytochrome P450 3A and 2C Activities with Testicular Steroids

(2012) G Zamaratskaia et al.   REPRODUCTION IN DOMESTIC ANIMALS

The sequence and analysis of a Chinese pig genome

(2012) Xiaodong Fang et al.   GigaScience

Expression and activities of hepatic cytochrome P450 (CYP1A, CYP2A and CYP2E1) in entire and castrated male pigs

(2011) C. Brunius et al.   Animal

Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry

(2011) B. Achour et al.   DRUG METABOLISM AND DISPOSITION

Role of the cytochrome P450 enzyme system in veterinary pharmacokinetics: where are we now? Where are we going?

(2011) Leposava Antonovic et al.   Future Medicinal Chemistry

Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

(2011) Romi Ghose et al.   LIFE SCIENCES

A metabolic system-wide characterisation of the pig: a model for human physiology

(2011) Claire A. Merrifield et al.   Molecular BioSystems

Coexistence of passive and carrier-mediated processes in drug transport

(2010) Kiyohiko Sugano et al.   NATURE REVIEWS DRUG DISCOVERY

EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs

(2009) Galia Zamaratskaia et al.   SENSORS

Tissue distribution of CYP3A29 mRNA expression in Bama miniature pig by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)

(2009) H. Shang et al.   XENOBIOTICA

Analyses of CYP2C in Porcine Microsomes

(2008) Mette T. Skaanild et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences

(2008) Johanna Fink-Gremmels   EUROPEAN JOURNAL OF PHARMACOLOGY