Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification

The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling

(2016) Emilie Barruet et al.   Stem Cell Research & Therapy

The Natural History of Flare-Ups in Fibrodysplasia Ossificans Progressiva (FOP): A Comprehensive Global Assessment

(2015) Robert J Pignolo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

(2015) Kyosuke Hino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

Inhibition of Activin A Ameliorates Skeletal Muscle Injury and Rescues Contractile Properties by Inducing Efficient Remodeling in Female Mice

(2014) Benjamin C. Yaden et al.   AMERICAN JOURNAL OF PATHOLOGY

Treatment of heterotopic ossification through remote ATP hydrolysis

(2014) J. R. Peterson et al.   Science Translational Medicine

Alk2 Regulates Early Chondrogenic Fate in Fibrodysplasia Ossificans Progressiva Heterotopic Endochondral Ossification

(2014) Andria L. Culbert et al.   STEM CELLS

Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor

(2013) Agustin H. Mohedas et al.   ACS Chemical Biology

The phenotype and genotype of fibrodysplasia ossificans progressiva in China: A report of 72 cases

(2013) Wei Zhang et al.   BONE

Regulation of MicroRNAs by Brahma-related Gene 1 (Brg1) in Smooth Muscle Cells

(2013) Meng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

(2013) Omar Abdel-Wahab et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation

(2013) J. Bagarova et al.   MOLECULAR AND CELLULAR BIOLOGY

Muscle Side Population Cells from Dystrophic or Injured Muscle Adopt a Fibro-Adipogenic Fate

(2013) Christopher M. Penton et al.   PLoS One

Osteogenic Differentiation Capacity of Human Skeletal Muscle-Derived Progenitor Cells

(2013) Teruyo Oishi et al.   PLoS One

Myotubularin-Deficient Myoblasts Display Increased Apoptosis, Delayed Proliferation, and Poor Cell Engraftment

(2012) Michael W. Lawlor et al.   AMERICAN JOURNAL OF PATHOLOGY

Glast-expressing progenitor cells contribute to heterotopic ossification

(2012) Lixin Kan et al.   BONE

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

(2012) Apirat Chaikuad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification

(2012) Michael N Wosczyna et al.   JOURNAL OF BONE AND MINERAL RESEARCH

AnAcvr1R206H knock-in mouse has fibrodysplasia ossificans progressiva

(2012) Salin A Chakkalakal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regional Differences in Stem Cell/Progenitor Cell Populations from the Mouse Achilles Tendon

(2012) Michael J. Mienaltowski et al.   TISSUE ENGINEERING PART A

Follistatin Improves Skeletal Muscle Healing after Injury and Disease through an Interaction with Muscle Regeneration, Angiogenesis, and Fibrosis

(2011) Jinhong Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Age-dependent fate and lineage restriction of single NG2 cells

(2011) X. Zhu et al.   DEVELOPMENT

Hyperactive BMP signaling induced by ALK2R206Hrequires type II receptor function in aDrosophilamodel for classic fibrodysplasia ossificans progressiva

(2011) Viet Q. Le et al.   DEVELOPMENTAL DYNAMICS

Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle

(2011) A. Uezumi et al.   JOURNAL OF CELL SCIENCE

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

Biomarker system for studying muscle, stem cells, and cancer in vivo

(2009) Koichi Nishijo et al.   FASEB JOURNAL

Identification of Progenitor Cells That Contribute to Heterotopic Skeletogenesis

(2009) Vitali Y Lounev et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Circulating Osteogenic Precursor Cells in Heterotopic Bone Formation

(2009) Robin K. Suda et al.   STEM CELLS

Fibrodysplasia ossificans progressiva

(2008) Frederick S. Kaplan et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

(2008) Frederick S. Kaplan et al.   HUMAN MUTATION

Constitutively Activated ALK2 and Increased SMAD1/5 Cooperatively Induce Bone Morphogenetic Protein Signaling in Fibrodysplasia Ossificans Progressiva

(2008) Toru Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE