Hyperactive BMP signaling induced by ALK2R206Hrequires type II receptor function in aDrosophilamodel for classic fibrodysplasia ossificans progressiva

A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H

(2011) Satoshi Ohte et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro Analyses of the Dysregulated R206H ALK2 Kinase-FKBP12 Interaction Associated with Heterotopic Ossification in FOP

(2011) Jay C. Groppe et al.   CELLS TISSUES ORGANS

Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling

(2011) Marcelo Ehrlich et al.   CELLULAR SIGNALLING

Cooperative Regulation of Growth by Yorkie and Mad through bantam

(2011) Hyangyee Oh et al.   DEVELOPMENTAL CELL

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

(2011) Tao Huang et al.   EMBO JOURNAL

Formation of Stable Homomeric and Transient Heteromeric Bone Morphogenetic Protein (BMP) Receptor Complexes Regulates Smad Protein Signaling

(2011) Barak Marom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding morphogenetic growth control — lessons from flies

(2011) Ortrud Wartlick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

Dynamics of Dpp Signaling and Proliferation Control

(2011) O. Wartlick et al.   SCIENCE

Formation of the Long Range Dpp Morphogen Gradient

(2011) Gerald Schwank et al.   PLOS BIOLOGY

Rapid evolution of a novel signalling mechanism by concerted duplication and divergence of a BMP ligand and its extracellular modulators

(2010) Cornelia Fritsch et al.   DEVELOPMENT GENES AND EVOLUTION

Molecular Consequences of the ACVR1R206HMutation of Fibrodysplasia Ossificans Progressiva

(2010) Gin-Ah Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interaction between two TGF-β type I receptors plays important roles in ligand binding, SMAD activation, and gradient formation

(2010) Theodor E. Haerry   MECHANISMS OF DEVELOPMENT

Bone Morphogenetic Protein-2 and -6 Heterodimer Illustrates the Nature of Ligand-Receptor Assembly

(2010) Michael J. Isaacs et al.   MOLECULAR ENDOCRINOLOGY

In VivoStructure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors

(2009) Jijun Hao et al.   ACS Chemical Biology

Intricacies of BMP receptor assembly

(2009) Joachim Nickel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The regulation of TGF  signal transduction

(2009) A. Moustakas et al.   DEVELOPMENT

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

Functional Analysis of saxophone, the Drosophila Gene Encoding the BMP Type I Receptor Ortholog of Human ALK1/ACVRL1 and ACVR1/ALK2

(2009) V. Twombly et al.   GENETICS

Novel Mutations in ACVR1 Result in Atypical Features in Two Fibrodysplasia Ossificans Progressiva Patients

(2009) Kirsten A. Petrie et al.   PLoS One

A unique case of fibrodysplasia ossificans progressiva with anACVR1 mutation, G356D, other than the common mutation (R206H)

(2008) Hirokazu Furuya et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Morphogen Control of Wing Growth through the Fat Signaling Pathway

(2008) Dragana Rogulja et al.   DEVELOPMENTAL CELL

Mutational analysis of the ACVR1 gene in Italian patients affected with fibrodysplasia ossificans progressiva: confirmations and advancements

(2008) Renata Bocciardi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

(2008) Frederick S. Kaplan et al.   HUMAN MUTATION

Constitutively Activated ALK2 and Increased SMAD1/5 Cooperatively Induce Bone Morphogenetic Protein Signaling in Fibrodysplasia Ossificans Progressiva

(2008) Toru Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)

(2008) Frederick S. Kaplan et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE