Interferon-Gamma Producing Regulatory T Cells as a Diagnostic and Therapeutic Tool in Organ Transplantation

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

(2014) W. Chen et al.   JOURNAL OF IMMUNOLOGY

In-vitro inhibition of IFNγ+ iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function

(2012) Volker Daniel et al.   BMC IMMUNOLOGY

CD4+CD25+Foxp3+IFNγ+CD178+ human induced Treg (iTreg) contribute to suppression of alloresponses by apoptosis of responder cells

(2012) Volker Daniel et al.   HUMAN IMMUNOLOGY

Identification of a human Th1-like IFNγ-secreting Treg subtype deriving from effector T cells

(2012) Ram Kumar Chowdary Venigalla et al.   JOURNAL OF AUTOIMMUNITY

IFN-  Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease

(2012) C. Koenecke et al.   JOURNAL OF IMMUNOLOGY

CD4+CD25+Foxp3+IFNγ+ Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLC

(2012) Volker Daniel et al.   TRANSPLANT IMMUNOLOGY

Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions

(2012) S. C. Juvet et al.   Journal of Molecular Cell Biology

Immunotherapy with IL-10- and IFN-γ-producing CD4 effector cells modulate “Natural” and “Inducible” CD4 TReg cell subpopulation levels: observations in four cases of patients with ovarian cancer

(2011) Mark J. Dobrzanski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Distinct regulatory CD4+T cell subsets; differences between naïve and antigen specific T regulatory cells

(2011) Bruce M Hall et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

(2011) Ting Feng et al.   GASTROENTEROLOGY

CD4+CD25+Foxp3+IFN-γ+ human induced T regulatory cells are induced by interferon-γ and suppress alloresponses nonspecifically

(2011) Volker Daniel et al.   HUMAN IMMUNOLOGY

IFN-γ– and IL-10–expressing virus epitope-specific Foxp3+T reg cells in the central nervous system during encephalomyelitis

(2011) Jingxian Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Physiologic Control of the Functional Status of Foxp3+ Regulatory T Cells

(2011) A. L. Mellor et al.   JOURNAL OF IMMUNOLOGY

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes

(2011) C.-R. Li et al.   Journal of Molecular Cell Biology

CD4+Foxp3+ regulatory T cell therapy in transplantation

(2011) Q. Tang et al.   Journal of Molecular Cell Biology

Induced Foxp3+ regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?

(2011) Q. Lan et al.   Journal of Molecular Cell Biology

TGF-β: the sword, the wand, and the shield of FOXP3+ regulatory T cells

(2011) Dat Q. Tran   Journal of Molecular Cell Biology

CD4+ Regulatory T Cells Generated in Vitro with IFN-γ and Allogeneic APC Inhibit Transplant Arteriosclerosis

(2010) Gregor Warnecke et al.   AMERICAN JOURNAL OF PATHOLOGY

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway

(2010) Jian Zheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Myelin-Reactive, TGF- -Induced Regulatory T Cells Can Be Programmed To Develop Th1-Like Effector Function but Remain Less Proinflammatory Than Myelin-Reactive Th1 Effectors and Can Suppress Pathogenic T Cell Clonal Expansion In Vivo

(2010) R. A. O'Connor et al.   JOURNAL OF IMMUNOLOGY

IL-17- and IFN- -Secreting Foxp3+ T Cells Infiltrate the Target Tissue in Experimental Autoimmunity

(2010) M. Esposito et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Correlation between Magnitude of MLC and Kidney Graft Survival in Intrafamilial Transplantation

(2010) O. Ringdén et al.   TISSUE ANTIGENS

IFN-γ Triggered STAT1-PKB/AKT Signalling Pathway Influences the Function of Alloantigen Reactive Regulatory T Cells

(2009) B. Wei et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

(2009) G. Wieczorek et al.   CANCER RESEARCH

Heterogeneity and plasticity of T helper cells

(2009) Jinfang Zhu et al.   CELL RESEARCH

How are TH1 and TH2 effector cells made?

(2009) Derk Amsen et al.   CURRENT OPINION IN IMMUNOLOGY

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions

(2009) João H. Duarte et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Allogeneic induced human FOXP3+IFN-γ+T cells exhibit selective suppressive capacity

(2009) Dina Stroopinsky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

(2009) Guillaume Oldenhove et al.   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

CD127low/- and FoxP3+ Expression Levels Characterize Different Regulatory T-Cell Populations in Human Peripheral Blood

(2009) Sandra Klein et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches

(2009) M. Tsuji et al.   SCIENCE

TGF-  and 'Adaptive' Foxp3+ Regulatory T cells

(2009) W. Chen et al.   Journal of Molecular Cell Biology

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

Critical role of IL-2 and TGF-β in generation, function and stabilization of Foxp3+CD4+ Treg

(2008) David A. Horwitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Exogenous IFN-γ ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells

(2008) Gang Feng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

(2008) Jonathan A. Hill et al.   IMMUNITY

Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells

(2008) M. Nagar et al.   INTERNATIONAL IMMUNOLOGY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY

Observational support for an immunoregulatory role of CD3+CD4+CD25+IFN-γ+blood lymphocytes in kidney transplant recipients with good long-term graft outcome

(2008) Volker Daniel et al.   TRANSPLANT INTERNATIONAL

Interferon-γ Conditioning Ex Vivo Generates CD25+CD62L+Foxp3+ Regulatory T Cells That Prevent Allograft Rejection: Potential Avenues for Cellular Therapy

(2008) Gang Feng et al.   TRANSPLANTATION