Conformational changes in the T cell receptor differentially determine T cell subset development in mice

Wiskott-Aldrich syndrome protein - dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes

(2014) Omri Matalon et al.   IMMUNOLOGICAL REVIEWS

The Proline-Rich Sequence of CD3  as an Amplifier of Low-Avidity TCR Signaling

(2014) P. Tailor et al.   JOURNAL OF IMMUNOLOGY

Relevance of Nck-CD3  Interaction for T Cell Activation In Vivo

(2014) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing

(2014) Elaine P. Dopfer et al.   Cell Reports

Ncking BCR-mediated PI3K activation

(2013) Jennifer L Cannons et al.   EMBO REPORTS

Modulation of T cell signaling by the actin cytoskeleton

(2013) Y. Yu et al.   JOURNAL OF CELL SCIENCE

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells

(2013) Angelo Castello et al.   NATURE IMMUNOLOGY

Innate NKTγδ and NKTαβ cells exert similar functions and compete for a thymic niche

(2012) Pablo Pereira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

(2012) Etienne Gagnon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development

(2012) A. Borroto et al.   JOURNAL OF IMMUNOLOGY

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes

(2012) Kavitha Narayan et al.   NATURE IMMUNOLOGY

Regulation of T Cell Homeostasis and Responses by Pten

(2012) Ryan H. Newton et al.   Frontiers in Immunology

Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells

(2011) Gleb Turchinovich et al.   IMMUNITY

T cell receptor signalling in γδ cell development: strength isn’t everything

(2011) Gleb Turchinovich et al.   TRENDS IN IMMUNOLOGY

αβ versus γδ fate choice: counting the T-cell lineages at the branch point

(2010) Taras Kreslavsky et al.   IMMUNOLOGICAL REVIEWS

Fine Tuning of the Threshold of T Cell Selection by the Nck Adapters

(2010) E. Roy et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Intrinsic Programming of Thymic   T Cells for Specific Peripheral Tissue Localization

(2010) Y. Jin et al.   JOURNAL OF IMMUNOLOGY

Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire

(2010) E. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds

(2010) M. Saini et al.   Science Signaling

Towards a molecular understanding of the differential signals regulating αβ/γδ T lineage choice

(2010) Sang-Yun Lee et al.   SEMINARS IN IMMUNOLOGY

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

(2009) Michelle L. Janas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical and Multiple Roles for the CD3  Intracytoplasmic Tail in Double Negative to Double Positive Thymocyte Differentiation

(2009) J.-F. Brodeur et al.   JOURNAL OF IMMUNOLOGY

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3 

(2009) N. Martinez-Martin et al.   Science Signaling

A Conserved CXXC Motif in CD3ε Is Critical for T Cell Development and TCR Signaling

(2009) Yibing Wang et al.   PLOS BIOLOGY

Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ

(2008) Kirk D.C. Jensen et al.   IMMUNITY

The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

(2008) Michaël Mingueneau et al.   NATURE IMMUNOLOGY

T Cell Receptor Engagement Triggers Its CD3ε and CD3ζ Subunits to Adopt a Compact, Locked Conformation

(2008) Ruth M. Risueño et al.   PLoS One