Data gaps limit the translational potential of preclinical research

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

Statins and epilepsy: preclinical studies, clinical trials and statin-anticonvulsant drug interactions

(2015) Francesca Scicchitano et al.   CURRENT DRUG TARGETS

Statins and Neuroprotection: Basic Pharmacology Needed

(2014) W. Gibson Wood et al.   MOLECULAR NEUROBIOLOGY

Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks

(2014) Stephen M Strittmatter   NATURE MEDICINE

Statins in neurological disorders: An overview and update

(2014) Anna Maria Malfitano et al.   PHARMACOLOGICAL RESEARCH

Mutations of the Huntington’s Disease Protein Impact on the ATM-Dependent Signaling and Repair Pathways of the Radiation-Induced DNA Double-Strand Breaks: Corrective Effect of Statins and Bisphosphonates

(2013) Mélanie L. Ferlazzo et al.   MOLECULAR NEUROBIOLOGY

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

(2013) Christie M Buchovecky et al.   NATURE GENETICS

A step closer to statin therapy for stroke?

(2013) Mitchell S. Elkind   Nature Reviews Neurology

Holding on to statins in Parkinson disease

(2013) E.-K. Tan et al.   NEUROLOGY

Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

(2013) Emily K. Osterweil et al.   NEURON

Second act

(2013) P. Nair   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Repurposing: Far Beyond New Targets for Old Drugs

(2012) T. I. Oprea et al.   AAPS Journal

Age-Dependent Rescue by Simvastatin of Alzheimer's Disease Cerebrovascular and Memory Deficits

(2012) X.-K. Tong et al.   JOURNAL OF NEUROSCIENCE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases

(2011) K. Xu et al.   BRIEFINGS IN BIOINFORMATICS

Mining for therapeutic gold

(2011) Francis S. Collins   NATURE REVIEWS DRUG DISCOVERY

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin

(2011) T. Kurata et al.   NEUROSCIENCE

Statins and neuroprotection

(2010) W. Gibson Wood et al.   Annals of the New York Academy of Sciences

The Future Is Much Closer Collaboration Between the Pharmaceutical Industry and Academic Medical Centers

(2010) P Vallance et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins in traumatic brain injury

(2010) Elissa F. Wible et al.   Neurotherapeutics

Simvastatin therapy prevents brain trauma-induced increases in β-amyloid peptide levels

(2009) Eric E. Abrahamson et al.   ANNALS OF NEUROLOGY

Addressing Central Nervous System (CNS) Penetration in Drug Discovery: Basics and Implications of the Evolving New Concept

(2009) Andreas Reichel   CHEMISTRY & BIODIVERSITY

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

(2009) Xin-Kang Tong et al.   NEUROBIOLOGY OF DISEASE

STATIN THERAPY IS ASSOCIATED WITH REDUCED NEUROPATHOLOGIC CHANGES OF ALZHEIMER DISEASE

(2008) G. J. Siegel et al.   NEUROLOGY