期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 8, 期 320, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aac9888
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资金
- NICHD NIH HHS [U54 HD090255] Funding Source: Medline
The absence of mouse pharmacokinetic reference data hinders translation. An analysis of recent literature highlights a systematic lack of discussion regarding rationale for the selection of dosing paradigms in preclinical studies, and in particular for neuroscience studies in which the lack of brain penetration can limit target-organ exposure. We propose solutions to improve study design.
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