Adenosine A2A receptor and ecto-5′-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE)

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs

(2016) Gemma Navarro et al.   BMC BIOLOGY

Purinergic signaling in epilepsy

(2016) François Rassendren et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Does rapid and physiological astrocyte-neuron signalling amplify epileptic activity?

(2016) Christian Henneberger   JOURNAL OF PHYSIOLOGY-LONDON

Adenosinergic signaling in epilepsy

(2016) Detlev Boison   NEUROPHARMACOLOGY

Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

(2015) Marco Matos et al.   BIOLOGICAL PSYCHIATRY

Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex

(2015) Aurora R. Barros-Barbosa et al.   EPILEPSIA

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development

(2015) Matthew L. Diamond et al.   EPILEPSIA

Framing Neuro-Glia Coupling in Antiepileptic Drug Design

(2015) Julianna Kardos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hyperthermia-induced seizures alter adenosine A1and A2Areceptors and 5′-nucleotidase activity in rat cerebral cortex

(2015) David Agustín León-Navarro et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

P2X7 receptor activation downmodulates Na+-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes

(2015) A.R. Barros-Barbosa et al.   NEUROSCIENCE

microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

(2015) Eva M. Jimenez-Mateos et al.   Scientific Reports

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Synaptic mechanisms of adenosine A2Areceptor-mediated hyperexcitability in the hippocampus

(2014) Diogo M. Rombo et al.   HIPPOCAMPUS

Activity-Dependent Adenosine Release May Be Linked to Activation of Na+-K+ ATPase: An In Vitro Rat Study

(2014) Robert Edward Sims et al.   PLoS One

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

(2013) Alba Jimenez-Pacheco et al.   EPILEPSIA

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

(2013) Rebecca L. Williams-Karnesky et al.   JOURNAL OF CLINICAL INVESTIGATION

Antagonistic Interaction between Adenosine A2A Receptors and Na+/K+-ATPase- 2 Controlling Glutamate Uptake in Astrocytes

(2013) M. Matos et al.   JOURNAL OF NEUROSCIENCE

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus

(2013) Mark J. Wall et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Imbalanced Expression of Adenosine Receptors in an Epilepsy Model Corrected Using Targeted Mesenchymal Stem Cell Transplantation

(2013) Kang Huicong et al.   MOLECULAR NEUROBIOLOGY

Decreased Extracellular Adenosine Levels Lead to Loss of Hypoxia-Induced Neuroprotection after Repeated Episodes of Exposure to Hypoxia

(2013) Mei Cui et al.   PLoS One

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

(2013) Sofia Cristóvão-Ferreira et al.   Purinergic Signalling

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Perirhinal cortex and temporal lobe epilepsy

(2013) Giuseppe Biagini et al.   Frontiers in Cellular Neuroscience

K+depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study

(2012) A Heinrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

A2aAdenosine Receptor Mediates PKA-Dependent Glutamate Release from Synaptic-like Vesicles and Ca2+Efflux from an IP3- and Ryanodine-Insensitive Intracellular Calcium Store in Astrocytes

(2012) Takeshi Kanno et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes

(2012) Marco Matos et al.   GLIA

Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling

(2012) Xiang Li et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Neuroprotection afforded by adenosine A2Areceptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons

(2012) Jorge S. Valadas et al.   JOURNAL OF NEUROCHEMISTRY

Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: A review

(2012) Casey M. O'Dell et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

(2011) Aude Panatier et al.   CELL

Differential neuroprotection by A1 receptor activation and A2A receptor inhibition following pilocarpine-induced status epilepticus

(2011) Fernanda Elisa Rosim et al.   EPILEPSY & BEHAVIOR

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

Brain-derived Neurotrophic Factor (BDNF) Enhances GABA Transport by Modulating the Trafficking of GABA Transporter-1 (GAT-1) from the Plasma Membrane of Rat Cortical Astrocytes

(2011) Sandra H. Vaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Activation of central adenosine A2A receptors lowers the seizure threshold of hyperthermia-induced seizure in childhood rats

(2010) Mitsumasa Fukuda et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation

(2009) Detlev Boison et al.   BIOCHEMICAL PHARMACOLOGY

Relative contribution of ecto-ATPase and ecto-ATPDase pathways to the biphasic effect of ATP on acetylcholine release from myenteric motoneurons

(2009) M Duarte-Araújo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Altered distribution and function of A2Aadenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease

(2009) Iolanda D’Alimonte et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms

(2009) Victor Bancila et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A receptor deficient mice are partially resistant to limbic seizures

(2009) Malika El Yacoubi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Adenosine A2a receptor induced gliosis via Akt/NF-κB pathway in vitro

(2009) Rong-Hu Ke et al.   NEUROSCIENCE RESEARCH

Evidence for the involvement of the adenosine A2A receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine

(2008) Malika El Yacoubi et al.   NEUROPHARMACOLOGY

Adenosine as a neuromodulator in neurological diseases

(2007) D BOISON   CURRENT OPINION IN PHARMACOLOGY