Review
Biochemistry & Molecular Biology
Alain Boussuges, Jeremy Bourenne, Farid Eloufir, Julien Fromonot, Giovanna Mottola, Jean Jacques Risso, Nicolas Vallee, Fabienne Bregeon, Regis Guieu
Summary: Exposure to extreme oxygen partial pressures can induce changes in the adenosinergic system, which play important roles in protecting the brain and lungs in high-altitude and deep-sea environments. Increased adenosine concentration helps protect the brain against hypoxia and is involved in the pathogenesis of mountain illness and neurological disorders. It also contributes to the prevention of high-altitude pulmonary edema and lung oxygen toxicity. On the other hand, decreased adenosine concentration during hyperoxic exposure leads to vasoconstriction and decreased cerebral blood flow, serving as a preventive measure against cerebral oxygen toxicity.
Article
Engineering, Biomedical
Yousheng Wu, Xiaoxiong Huang, Zefeng Tan, Jiankun Zang, Min Peng, Niu He, Tao Zhang, Hongcheng Mai, Anding Xu, Dan Lu
Summary: This study systematically investigated the properties and protein composition of small extracellular vesicles (sEVs) derived from neurons under hypoxic conditions. The results showed that the involvement of these sEVs in the onset and progression of ischemic stroke is still unclear. Through various analyses, the study identified the characteristics and therapeutic effects of these hypoxia-induced EVs, demonstrating their potential for neuroprotection against ischemic stroke.
BIOACTIVE MATERIALS
(2023)
Article
Cell Biology
Pavel Tregub, Yuri Motin, Vladimir Kulikov, Pavel Kovzelev, Aleksandra Chaykovskaya, Irada Ibrahimli
Summary: Isolated exposure to intermittent hypoxia and permissive hypercapnia induces ultrastructural changes in mitochondria and endoplasmic reticulum, leading to maximal ischemic tolerance in neurons. This study compares the ultrastructural changes in hippocampal neurons after isolated and combined exposure to hypoxia and hypercapnia and correlates these changes with neuroprotective effects. The findings suggest that hypoxia and hypercapnia have varying effects on organelles responsible for neuron functions, with hypercapnia playing a dominant role in neuroprotection.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Zai-Hua Zhao, Ke-Jun Du, Tao Wang, Ji-Ye Wang, Zi-Peng Cao, Xiao-Ming Chen, Han Song, Gang Zheng, Xue-Feng Shen
Summary: The study found that gestational lead exposure in rats can impair spatial learning and memory, as well as hippocampal synaptic plasticity at postnatal day 30. Lead exposure induced a decrease in hippocampal glucose metabolism by reducing GLUT4 levels in the cell membrane through the PI3K-Akt pathway. Increasing GLUT4 expression reversed the lead-induced impairment in synaptic plasticity and cognition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Isabella Zironi, Giorgio Aicardi
Summary: This study found that postnatal asphyxia can reversibly depress glutamatergic synaptic transmission and neuronal excitability in the primary motor cortex, through the mediation of molecules such as adenosine and nitric oxide. These effects may be helpful in preventing acute and long-term neurological consequences of postnatal asphyxia.
Article
Engineering, Environmental
Naga Raju Maddela, Ronald Oswaldo Villamar Torres
Summary: The presence of low fouling-causing bacteria in a dual-species culture can significantly reduce the membrane fouling potential of high fouling-causing bacteria through interspecies interactions. Fourier transform infrared analyses show that low fouling-causing bacteria can modulate the extracellular polymeric substances functional groups of high/low fouling-causing bacteria mixed cultures, thereby alleviating membrane fouling. Isolation and application of low fouling-causing bacteria in membrane bioreactors can be a promising method for membrane fouling control through specific cell-to-cell interactions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Environmental Sciences
Chung-Shin Yuan, Ching-Shu Lai, Yu-Lun Tseng, Ping-Chi Hsu, Chieh-Mo Lin, Fu-Jen Cheng
Summary: The study showed that exposure to PM2.5 induced inflammatory signaling and cytokines upregulation in the liver, as well as increased cell proliferation signals. Different exposure groups exhibited distinct biological effects on liver inflammation and cell proliferation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Anggraeini Puspitasari, Fabio Squarcio, Martina Quartieri, Cristina Totis, Timna Hitrec, Akihisa Takahashi, Yukari Yoshida, Kenji Hanamura, Tomoko Yako, Matteo Cerri, Palma Simoniello, Marco Durante, Walter Tinganelli
Summary: Hibernation or torpor is a potential method to protect astronauts from space radiation, and it involves reducing skin temperature and increasing survival rate. Synthetic torpor also delays DNA repair and suppresses radiation-induced mitotic catastrophe.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
P. P. Tregub, N. A. Malinovskaya, E. D. Osipova, A. V. Morgun, V. P. Kulikov, D. A. Kuzovkov
Summary: The study found that the combination of hypercapnia and hypoxia can increase the relative number of A1-adenosine receptors and mitoK(ATP)(+)-channels in astrocytes, potentially enhancing their neuroprotective effects. However, hypercapnia alone does not have this effect.
NEUROMOLECULAR MEDICINE
(2022)
Article
Neurosciences
Roxana Paula Ginerete, Giada Mascio, Francesca Liberatore, Domenico Bucci, Nico Antenucci, Paola Di Pietro, Milena Cannella, Tiziana Imbriglio, Serena Notartomaso, Ferdinando Nicoletti, Valeria Bruno, Giuseppe Battaglia
Summary: The study suggests that exposure to ROE simulating air cabin conditions of domestic flights may enhance resilience to stress improving mood, anxiety and learning ability.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Materials Science, Textiles
Rochak Rathour, Apurba Das, Ramasamy Alagirusamy
Summary: This study investigated the durability of firefighters' protective clothing, and found that fabric material, pick density, exposure cycles, and heat flux intensity significantly affect the performance of the clothing. The results can provide guidance for textile designers in creating more thermo-stable and durable turnout suits.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Review
Public, Environmental & Occupational Health
J. Z. Yin, M. E, H. Chao
Summary: This study conducted a meta-analysis to determine the association between environmental lead exposure and hearing loss. The results showed a significant association between lead exposure and hearing loss, with higher lead exposure correlating with increased risk of hearing loss. Larger prospective cohort studies are needed to further clarify this relationship.
Article
Environmental Sciences
Bin Wang, Wen Zhang, Chi Chen, Yi Chen, Fangzhen Xia, Ningjian Wang, Yingli Lu
Summary: Experimental studies suggest the diabetogenic effects of lead, but relevant data in humans are limited and have been primarily based on cross-sectional study design. This study aimed to prospectively examine the association between lead exposure and glucose homeostasis in the general population using repeated measurements.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cardiac & Cardiovascular Systems
Mona Lichtblau, Patrick R. Bader, Arcangelo F. Carta, Michael Furian, Lara Muralt, Stephanie Saxer, Sara E. Hartmann, Jean M. Rawling, Marc J. Poulin, Konrad E. Bloch, Silvia Ulrich
Summary: Exposure to high altitude led to rapid increase in systolic pulmonary artery pressure (sPAP) and increased extravascular lung water (EVLW), with sPAP decreasing gradually while EVLW continued to rise during prolonged exposures. Repeated high-altitude exposure did not result in acclimatization effect on EVLW, indicating potential implications for individuals needing repetitive ascents to altitude.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Neurosciences
Rita Rosati, Johnna A. Birbeck, Judy Westrick, Samson Jamesdaniel
Summary: Long-term environmental exposure to lead can cause hearing impairment and damage to neurons and synaptic function. This study found that lead exposure leads to disruption of cochlear synapses and nitrotyrosine-induced stress.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)