microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

A Dynamic Search Process Underlies MicroRNA Targeting

(2015) Stanley D. Chandradoss et al.   CELL

Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats

(2015) Neha Soni et al.   EPILEPSY & BEHAVIOR

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

(2015) Leah D. Gershen et al.   JAMA Neurology

Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

(2015) Suzanne F.C. Miller-Delaney et al.   BRAIN

The search for circulating epilepsy biomarkers

(2014) Manu Hegde et al.   Biomarkers in Medicine

Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus

(2014) Eva M. Jimenez-Mateos et al.   Brain Structure & Function

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

The complexity of miRNA-mediated repression

(2014) A Wilczynska et al.   CELL DEATH AND DIFFERENTIATION

P2X7 Receptor Inhibition Interrupts the Progression of Seizures in Immature Rats and Reduces Hippocampal Damage

(2014) Guillaume Mesuret et al.   CNS Neuroscience & Therapeutics

MicroRNA and epilepsy

(2014) David C. Henshall   CURRENT OPINION IN NEUROLOGY

Neuroprotective Effects of Viral Overexpression of microRNA-22 in Rat and Cell Models of Cerebral Ischemia-Reperfusion Injury

(2014) Houyou Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

(2014) Mathieu Letellier et al.   NATURE NEUROSCIENCE

Differential RISC association of endogenous human microRNAs predicts their inhibitory potential

(2014) Omar Flores et al.   NUCLEIC ACIDS RESEARCH

Identification of miRNAs Differentially Expressed in Human Epilepsy with or without Granule Cell Pathology

(2014) Silvia Zucchini et al.   PLoS One

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

CHOP regulates the p53–MDM2 axis and is required for neuronal survival after seizures

(2013) Tobias Engel et al.   BRAIN

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

(2013) Anindya Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

(2013) Alba Jimenez-Pacheco et al.   EPILEPSIA

MicroRNA 22 Regulates Cell Cycle Length in Cerebellar Granular Neuron Precursors

(2013) J. Berenguer et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcranial amelioration of inflammation and cell death after brain injury

(2013) Theodore L. Roth et al.   NATURE

First microRNA mimic enters clinic

(2013) Aaron Bouchie   NATURE BIOTECHNOLOGY

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Changes in MicroRNA Expression in the Whole Hippocampus and Hippocampal Synaptoneurosome Fraction following Pilocarpine Induced Status Epilepticus

(2013) Rashmi M. Risbud et al.   PLoS One

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington’s Disease-Related Mechanisms

(2013) Ana Jovicic et al.   PLoS One

miR-150 Promotes Human Breast Cancer Growth and Malignant Behavior by Targeting the Pro-Apoptotic Purinergic P2X7 Receptor

(2013) Songyin Huang et al.   PLoS One

MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice

(2013) C. L. Tan et al.   SCIENCE

Inflammatory pathways of seizure disorders

(2013) Nicola Marchi et al.   TRENDS IN NEUROSCIENCES

MicroRNAs in the pathophysiology and treatment of status epilepticus

(2013) David C. Henshall   Frontiers in Molecular Neuroscience

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response

(2012) Anne A. Kan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

The Specificity Protein Factor Sp1 Mediates Transcriptional Regulation of P2X7 Receptors in the Nervous System

(2012) Paula García-Huerta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Activity-Regulated microRNA, miR-188, Controls Dendritic Plasticity and Synaptic Transmission by Downregulating Neuropilin-2

(2012) K. Lee et al.   JOURNAL OF NEUROSCIENCE

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

Failed epilepsy surgery for mesial temporal lobe sclerosis: a review of the pathophysiology

(2012) Fernando L. Vale et al.   Neurosurgical Focus

Reduced Mature MicroRNA Levels in Association with Dicer Loss in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis

(2012) Ross C. McKiernan et al.   PLoS One

MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response

(2012) Anand Iyer et al.   PLoS One

Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy

(2011) Fabien Pernot et al.   EPILEPSIA

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice

(2011) Ji-Eun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Activation of the Transcription Factor FosB/Activating Protein-1 (AP-1) Is a Prominent Downstream Signal of the Extracellular Nucleotide Receptor P2RX7 in Monocytic and Osteoblastic Cells

(2010) Monica L. Gavala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Expression profile of microRNAs in rat hippocampus following lithium–pilocarpine-induced status epilepticus

(2010) Kai Hu et al.   NEUROSCIENCE LETTERS

Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein

(2010) J Xiong et al.   ONCOGENE

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

(2009) Andreas Junker et al.   BRAIN

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Impact of normalization on miRNA microarray expression profiling

(2009) S. Pradervand et al.   RNA

Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice

(2008) Genshin Mouri et al.   BRAIN RESEARCH

Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine

(2008) Flavia Doná et al.   EPILEPSY RESEARCH

MicroRNAs miR-186 and miR-150 Down-regulate Expression of the Pro-apoptotic Purinergic P2X7Receptor by Activation of Instability Sites at the 3′-Untranslated Region of the Gene That Decrease Steady-state Levels of the Transcript

(2008) Lingyin Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways

(2008) Eva M. Jimenez-Mateos et al.   NEUROBIOLOGY OF DISEASE

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain

(2007) Rozenn Mingam et al.   BRAIN BEHAVIOR AND IMMUNITY

The adenosine kinase hypothesis of epileptogenesis

(2007) Detlev Boison   PROGRESS IN NEUROBIOLOGY