Protein lipid modifications-More than just a greasy ballast

Mass Spectrometry Cleavable Strategy for Identification and Differentiation of Prenylated Peptides

(2015) Ruchika P. Bhawal et al.   ANALYTICAL CHEMISTRY

Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development

(2015) Malgorzata Broncel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Global profiling of protein lipidation using chemical proteomic technologies

(2015) Edward W Tate et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Current strategies and findings in clinically relevant post-translational modification-specific proteomics

(2015) Oliver Pagel et al.   Expert Review of Proteomics

An improved workflow for quantitative N-terminal charge-based fractional diagonal chromatography (ChaFRADIC) to study proteolytic events inArabidopsis thaliana

(2015) A. Saskia Venne et al.   PROTEOMICS

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

(2015) Akshata Moghe et al.   TOXICOLOGICAL SCIENCES

Identification of a Family of Fatty-Acid-Speciated Sonic Hedgehog Proteins, Whose Members Display Differential Biological Properties

(2015) Jun Long et al.   Cell Reports

Rac1 modification by an electrophilic 15-deoxy Δ12,14-prostaglandin J2 analog

(2015) S.B. Wall et al.   Redox Biology

Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability

(2014) A Rossin et al.   CELL DEATH AND DIFFERENTIATION

Assay of Protein and Peptide Adducts of Cholesterol Ozonolysis Products by Hydrophobic and Click Enrichment Methods

(2014) Katherine Windsor et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Differential Palmitoylation States of N-Ras and H-Ras Determine Their Distinct Golgi Subcompartment Localizations

(2014) Stephen J. Lynch et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

(2014) Paulina Ciepla et al.   Chemical Science

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

(2014) Emmanuelle Thinon et al.   Nature Communications

Acrolein Exposure Is Associated With Increased Cardiovascular Disease Risk

(2014) Natasha DeJarnett et al.   Journal of the American Heart Association

Direct Detection of S-Palmitoylation by Mass Spectrometry

(2013) Yuhuan Ji et al.   ANALYTICAL CHEMISTRY

Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation

(2013) Chen Kong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Investigation of LKB1 Ser431phosphorylation and Cys433farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

(2013) Vanessa P. Houde et al.   BIOCHEMICAL JOURNAL

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

What does S-palmitoylation do to membrane proteins?

(2013) Sanja Blaskovic et al.   FEBS Journal

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

(2013) H. Ding et al.   HAEMATOLOGICA

Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome

(2013) Katherine Windsor et al.   JOURNAL OF LIPID RESEARCH

Pathophysiological relevance of aldehydic protein modifications

(2013) Neven Zarkovic et al.   Journal of Proteomics

Electron Capture Dissociation and Collision Induced Dissociation of S-Dipalmitoylated Peptides

(2013) Małgorzata A. Kaczorowska et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Palmitoylation on Conserved and Nonconserved Cysteines of Murine IFITM1 Regulates Its Stability and Anti-Influenza A Virus Activity

(2013) J. C. Hach et al.   JOURNAL OF VIROLOGY

Malondialdehyde regulates glucose-stimulated insulin secretion in murine islets via TCF7L2-dependent Wnt signaling pathway

(2013) Xinhui Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

(2013) Xinxin Gao et al.   Nature Chemical Biology

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

(2013) Chu Wang et al.   NATURE METHODS

The next level of complexity: Crosstalk of posttranslational modifications

(2013) A. Saskia Venne et al.   PROTEOMICS

Hypoxia Stress Test Reveals Exaggerated Cardiovascular Effects in Hypertensive Rats After Exposure to the Air Pollutant Acrolein

(2013) Christina M. Perez et al.   TOXICOLOGICAL SCIENCES

Liquid Chromatographic Analysis and Mass Spectrometric Identification of Farnesylated Peptides

(2012) Marina Wotske et al.   ANALYTICAL CHEMISTRY

The innate immune response to products of phospholipid peroxidation

(2012) David Weismann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Flexible and General Synthesis of Functionalized Phosphoisoprenoids for the Study of Prenylation in vivo and in vitro

(2012) Debapratim Das et al.   CHEMBIOCHEM

Recent Advancements in the LC- and GC-Based Analysis of Malondialdehyde (MDA): A Brief Overview

(2012) Martin Giera et al.   CHROMATOGRAPHIA

Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2α

(2012) Dimitrios Tsikas et al.   FEBS LETTERS

Differential oxidative modification of proteins in MRL+/+ and MRL/lpr mice: Increased formation of lipid peroxidation-derived aldehyde-protein adducts may contribute to accelerated onset of autoimmune response

(2012) Gangduo Wang et al.   FREE RADICAL RESEARCH

Hedgehog Secretion and Signal Transduction in Vertebrates

(2012) Kaitlyn E. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Palmitoylation and Ubiquitination Differentially Regulate Interferon-induced Transmembrane Protein 3 (IFITM3)-mediated Resistance to Influenza Virus

(2012) Jacob S. Yount et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels

(2012) Lijun Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shotgun lipidomics on a LTQ Orbitrap mass spectrometer by successive switching between acquisition polarity modes

(2012) Kai Schuhmann et al.   JOURNAL OF MASS SPECTROMETRY

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

(2012) Min Yuan et al.   Nature Protocols

Palmitoylation by DHHC5/8 Targets GRIP1 to Dendritic Endosomes to Regulate AMPA-R Trafficking

(2012) Gareth M. Thomas et al.   NEURON

Instant spectral assignment for advanced decision tree-driven mass spectrometry

(2012) D. J. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal

(2012) Ying Huang et al.   Cell and Bioscience

Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand

(2012) Hanna Tukachinsky et al.   Cell Reports

Bioorthogonal Chemical Reporters for Analyzing Protein Lipidation and Lipid Trafficking

(2011) Howard C. Hang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice

(2011) Sanjay Srivastava et al.   ATHEROSCLEROSIS

Adduction of Cholesterol 5,6-Secosterol Aldehyde to Membrane-Bound Myelin Basic Protein Exposes an Immunodominant Epitope

(2011) Natalie K. Cygan et al.   BIOCHEMISTRY

Protein palmitoylation and subcellular trafficking

(2011) Clara Aicart-Ramos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts

(2011) Giorgia Volpi et al.   BRITISH JOURNAL OF PHARMACOLOGY

An1O2Route to γ-Hydroxyalkenal Phospholipids by Vitamin E-Induced Fragmentation of Hydroperoxydiene-Derived Endoperoxides

(2011) Xiaodong Gu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Cholesterol Secosterol Aldehydes Induce Amyloidogenesis and Dysfunction of Wild-Type Tumor Protein p53

(2011) Jorge Nieva et al.   CHEMISTRY & BIOLOGY

Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis

(2011) Peeter Karihtala et al.   HISTOPATHOLOGY

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

(2011) Xin Chen et al.   JOURNAL OF CELL BIOLOGY

DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors

(2011) Ali Pedram et al.   MOLECULAR BIOLOGY OF THE CELL

DHHC2 is a proteinS-acyltransferase for Lck

(2011) Ruth Zeidman et al.   MOLECULAR MEMBRANE BIOLOGY

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapid isolation and characterization of bacterial lipopeptides using liquid chromatography and mass spectrometry analysis

(2011) Yan Kwok et al.   PROTEOMICS

DHHC palmitoyl transferases: substrate interactions and (patho)physiology

(2011) Jennifer Greaves et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity

(2011) Nir London et al.   PLoS Computational Biology

Systems Analysis of Protein Modification and Cellular Responses Induced by Electrophile Stress

(2010) Aaron T. Jacobs et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box

(2010) Florian Baumgart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Post-translational myristoylation: Fat matters in cellular life and death

(2010) Dale D.O. Martin et al.   BIOCHIMIE

Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry

(2010) Alexandra F. H. Berry et al.   CHEMBIOCHEM

Azide: A Unique Dipole for Metal-Free Bioorthogonal Ligations

(2010) Marjoke F. Debets et al.   CHEMBIOCHEM

Malondialdehyde–acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis

(2010) Michael J. Duryee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multiple Palmitoyltransferases Are Required for Palmitoylation-dependent Regulation of Large Conductance Calcium- and Voltage-activated Potassium Channels

(2010) Lijun Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of the SNAP25 Protein Family

(2010) Jennifer Greaves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

Palmitoylation and depalmitoylation dynamics at a glance

(2010) Elizabeth Conibear et al.   JOURNAL OF CELL SCIENCE

Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome

(2010) Zeljka Korade et al.   JOURNAL OF LIPID RESEARCH

Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia

(2010) L Yu et al.   LEUKEMIA

Proteomic Analysis of Fatty-acylated Proteins in Mammalian Cells with Chemical Reporters RevealsS-Acylation of Histone H3 Variants

(2010) John P. Wilson et al.   MOLECULAR & CELLULAR PROTEOMICS

DHHC20: a human palmitoyl acyltransferase that causes cellular transformation

(2010) Jeremiah M. Draper et al.   MOLECULAR MEMBRANE BIOLOGY

Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

(2010) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

The chemical toolbox for monitoring protein fatty acylation and prenylation

(2010) Rami N Hannoush et al.   Nature Chemical Biology

Acyl-Protein Thioesterase 2 Catalizes the Deacylation of Peripheral Membrane-Associated GAP-43

(2010) Vanesa M. Tomatis et al.   PLoS One

Regulation of Ras Localization by Acylation Enables a Mode of Intracellular Signal Propagation

(2010) A. Lorentzen et al.   Science Signaling

A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older

(2009) J.-L. Harousseau et al.   BLOOD

Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders

(2009) Mark P. Mattson   EXPERIMENTAL GERONTOLOGY

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity

(2009) Kun Huang et al.   FASEB JOURNAL

Suppression of APP-containing vesicle trafficking and production of β-amyloid by AID/DHHC-12 protein

(2009) Chie Mizumaru et al.   JOURNAL OF NEUROCHEMISTRY

Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters

(2009) Guillaume Charron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteome Scale Characterization of HumanS-Acylated Proteins in Lipid Raft-enriched and Non-raft Membranes

(2009) Wei Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

Palmitoylation of Cytoskeleton Associated Protein 4 by DHHC2 Regulates Antiproliferative Factor-mediated Signaling

(2009) Sonia L. Planey et al.   MOLECULAR BIOLOGY OF THE CELL

The Hydrophobic Cysteine-rich Domain of SNAP25 Couples with Downstream Residues to Mediate Membrane Interactions and Recognition by DHHC Palmitoyl Transferases

(2009) Jennifer Greaves et al.   MOLECULAR BIOLOGY OF THE CELL

Protein acyl thioesterases (Review)

(2009) Ruth Zeidman et al.   MOLECULAR MEMBRANE BIOLOGY

Dual Palmitoylation of NR2 Subunits Regulates NMDA Receptor Trafficking

(2009) Takashi Hayashi et al.   NEURON

Metabolic labeling and direct imaging of choline phospholipids in vivo

(2009) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding

(2009) Tiyu Gao et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Highly efficient and selective enrichment of peptide subsets combining fluorous chemistry with reversed-phase chromatography

(2009) Wantao Ying et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Palmitoylation Regulates Epidermal Homeostasis and Hair Follicle Differentiation

(2009) Pleasantine Mill et al.   PLoS Genetics

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

(2008) Henry Jay Forman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lipid-Derived Aldehydes Accelerate Light Chain Amyloid and Amorphous Aggregation†

(2008) Jorge Nieva et al.   BIOCHEMISTRY

Nanoscale Organization of Hedgehog Is Essential for Long-Range Signaling

(2008) Neha Vyas et al.   CELL

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

(2008) Vladimir L Katanaev et al.   EMBO JOURNAL

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Palmitoylation and Membrane Interactions of the Neuroprotective Chaperone Cysteine-string Protein

(2008) Jennifer Greaves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin-interacting Proteins, HIP14 and HIP14L, Mediate Dual Functions, Palmitoyl Acyltransferase and Mg2+Transport

(2008) Angela Goytain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer Disease Aβ Production in the Absence ofS-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

(2008) Kulandaivelu S. Vetrivel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Adducts with Lipid Peroxidation Products

(2008) Ian A. Blair   JOURNAL OF BIOLOGICAL CHEMISTRY

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes

(2008) Jamil Kanaani et al.   JOURNAL OF CELL SCIENCE

Role of Oxidative Stress in Adaptive Responses in Special Reference to Atherogenesis

(2008) Noriko Noguchi   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS

(2008) Akira Honda et al.   JOURNAL OF LIPID RESEARCH

Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCε signaling and cardioprotection

(2008) Guang-Wu Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of G Protein   Subunit-Palmitoylating Enzyme

(2008) R. Tsutsumi et al.   MOLECULAR AND CELLULAR BIOLOGY

DHHC2 Affects Palmitoylation, Stability, and Functions of Tetraspanins CD9 and CD151

(2008) Chandan Sharma et al.   MOLECULAR BIOLOGY OF THE CELL

Decision tree–driven tandem mass spectrometry for shotgun proteomics

(2008) Danielle L Swaney et al.   NATURE METHODS

N-Myristoyl transferase-mediated protein labelling in vivo

(2008) William P. Heal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Palmitoylation Controls Recycling in Lysosomal Sorting and Trafficking

(2008) Peter J. McCormick et al.   TRAFFIC

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

(2007) A Negre-Salvayre et al.   BRITISH JOURNAL OF PHARMACOLOGY

4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

(2007) G. Poli et al.   MEDICINAL RESEARCH REVIEWS