Ligand binding to the PDZ domains of postsynaptic density protein 95

Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ–RhoGEF

(2015) Heath G. Pascoe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

(2015) Klaus B. Nissen et al.   PLoS One

Rigidified Clicked Dimeric Ligands for Studying the Dynamics of the PDZ1-2 Supramodule of PSD-95

(2014) Jonas N. N. Eildal et al.   CHEMBIOCHEM

Structure of Crumbs tail in complex with the PALS1 PDZ–SH3–GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex

(2014) Youjun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of Multivalent PDZ Domain Binding to the Scaffold Protein PSD-95 Reveals Ternary-Complex Specificity of Combinatorial Inhibition

(2014) James J. McCann et al.   STRUCTURE

Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

(2014) Søren W. Pedersen et al.   Nature Communications

Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures

(2013) Fei Ye et al.   BIOCHEMICAL JOURNAL

Probing the Role of Backbone Hydrogen Bonds in Protein–Peptide Interactions by Amide-to-Ester Mutations

(2013) Jonas N. N. Eildal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Supertertiary Structure of the MAGUK Core from PSD-95

(2013) Jun Zhang et al.   STRUCTURE

Interactions outside the Boundaries of the Canonical Binding Groove of a PDZ Domain Influence Ligand Binding

(2012) Celestine N. Chi et al.   BIOCHEMISTRY

Ligand binding by PDZ domains

(2012) Celestine N. Chi et al.   BIOFACTORS

The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains

(2012) Katja Luck et al.   FEBS LETTERS

Plasticity of PDZ domains in ligand recognition and signaling

(2012) Ylva Ivarsson   FEBS LETTERS

The Transition State of Coupled Folding and Binding for a Flexible β-Finger

(2012) O. Andreas Karlsson et al.   JOURNAL OF MOLECULAR BIOLOGY

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

Supertertiary structure of the synaptic MAGuK scaffold proteins is conserved

(2012) J. J. McCann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond the Binding Site: The Role of the β2 – β3 Loop and Extra-Domain Structures in PDZ Domains

(2012) Stefano Mostarda et al.   PLoS Computational Biology

The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Protein Suggests a Supramodular Organization of the Membrane-associated Guanylate Kinase (MAGUK) Family Scaffold Protein Core

(2011) Lifeng Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence-specific Long Range Networks in PSD-95/Discs Large/ZO-1 (PDZ) Domains Tune Their Binding Selectivity

(2011) Stefano Gianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1

(2011) Julian Nomme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging mechanisms of disrupted cellular signaling in brain ischemia

(2011) Michael Tymianski   NATURE NEUROSCIENCE

Biophysical Characterization of the Complex between Human Papillomavirus E6 Protein and Synapse-associated Protein 97

(2010) Celestine N. Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example

(2010) Celestine N. Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization

(2010) Matthieu Sainlos et al.   Nature Chemical Biology

Design and Synthesis of Highly Potent and Plasma-Stable Dimeric Inhibitors of the PSD-95-NMDA Receptor Interaction

(2009) Anders Bach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Creating Conformational Entropy by Increasing Interdomain Mobility in Ligand Binding Regulation: A Revisit to N-Terminal Tandem PDZ Domains of PSD-95

(2008) Wenning Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY