Plasticity of PDZ domains in ligand recognition and signaling

Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish

(2012) K. Lambaerts et al.   JOURNAL OF CELL SCIENCE

The Transition State of Coupled Folding and Binding for a Flexible β-Finger

(2012) O. Andreas Karlsson et al.   JOURNAL OF MOLECULAR BIOLOGY

Genome-wide Functional Annotation of Dual-Specificity Protein- and Lipid-Binding Modules that Regulate Protein Interactions

(2012) Yong Chen et al.   MOLECULAR CELL

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond the Binding Site: The Role of the β2 – β3 Loop and Extra-Domain Structures in PDZ Domains

(2012) Stefano Mostarda et al.   PLoS Computational Biology

A Dynamic View of Domain-Motif Interactions

(2012) Eyal Akiva et al.   PLoS Computational Biology

Rewiring of PDZ Domain-Ligand Interaction Network Contributed to Eukaryotic Evolution

(2012) Jinho Kim et al.   PLoS Genetics

The structural flexibility of the shank1 PDZ domain is important for its binding to different ligands

(2011) Jun Hyuck Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serine 77 in the PDZ Domain of PICK1 Is a Protein Kinase Cα Phosphorylation Site Regulated by Lipid Membrane Binding

(2011) Ina Ammendrup-Johnsen et al.   BIOCHEMISTRY

The INAD Scaffold Is a Dynamic, Redox-Regulated Modulator of Signaling in the Drosophila Eye

(2011) Wei Liu et al.   CELL

Hot Spots for Allosteric Regulation on Protein Surfaces

(2011) Kimberly A. Reynolds et al.   CELL

A Systematic Family-wide Investigation Reveals that ∼30% of Mammalian PDZ Domains Engage in PDZ-PDZ Interactions

(2011) Bryan H. Chang et al.   CHEMISTRY & BIOLOGY

Structure of the Membrane-tethering GRASP Domain Reveals a Unique PDZ Ligand Interaction That Mediates Golgi Biogenesis

(2011) Steven T. Truschel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Phosphoinositide and Peptide Binding by PSD-95/Discs Large/ZO-1 (PDZ) Domain of Polychaetoid,DrosophilaZonulin

(2011) Ylva Ivarsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Protein Suggests a Supramodular Organization of the Membrane-associated Guanylate Kinase (MAGUK) Family Scaffold Protein Core

(2011) Lifeng Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence-specific Long Range Networks in PSD-95/Discs Large/ZO-1 (PDZ) Domains Tune Their Binding Selectivity

(2011) Stefano Gianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of a PDZ Domain Extension Modulates Binding Affinity and Interdomain Interactions in Postsynaptic Density-95 (PSD-95) Protein, a Membrane-associated Guanylate Kinase (MAGUK)

(2011) Jun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains

(2011) S. Raza Haq et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging Theme: Cellular PDZ Proteins as Common Targets of Pathogenic Viruses

(2011) R. T. Javier et al.   JOURNAL OF VIROLOGY

E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1

(2011) R. Accardi et al.   JOURNAL OF VIROLOGY

Detailed Regulatory Mechanism of the Interaction between ZO-1 PDZ2 and Connexin43 Revealed by MD Simulations

(2011) Fei Xiao et al.   PLoS One

Putting into Practice Domain-Linear Motif Interaction Predictions for Exploration of Protein Networks

(2011) Katja Luck et al.   PLoS One

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27

(2011) B. Balana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

A Conformational Switch in the CRIB-PDZ Module of Par-6

(2011) Dustin S. Whitney et al.   STRUCTURE

Redox-Regulated Lipid Membrane Binding of the PICK1 PDZ Domain

(2010) Yawei Shi et al.   BIOCHEMISTRY

A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding

(2010) Nicolas Lenfant et al.   BMC GENOMICS

Structural Diversity of PDZ-Lipid Interactions

(2010) Rodrigo Gallardo et al.   CHEMBIOCHEM

MAGI-3 Competes With NHERF-2 to Negatively Regulate LPA2 Receptor Signaling in Colon Cancer Cells

(2010) Sei–Jung Lee et al.   GASTROENTEROLOGY

Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example

(2010) Celestine N. Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitotic Inhibition of GRASP65 Organelle Tethering Involves Polo-like Kinase 1 (PLK1) Phosphorylation Proximate to an Internal PDZ Ligand

(2010) Debrup Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis

(2010) Kim-Tat Teoh et al.   MOLECULAR BIOLOGY OF THE CELL

Coevolution of PDZ domain–ligand interactions analyzed by high-throughput phage display and deep sequencing

(2010) Andreas Ernst et al.   Molecular BioSystems

Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain

(2010) Stefano Gianni et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

(2010) Melisa Merdanovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization

(2010) Xin Shao et al.   NEUROCHEMISTRY INTERNATIONAL

Evidence for PDZ domains in bacteria, yeast, and plants

(2010) Christopher P. Ponting   PROTEIN SCIENCE

How viruses hijack cell regulation

(2010) Norman E. Davey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ablation of Whirlin Long Isoform Disrupts the USH2 Protein Complex and Causes Vision and Hearing Loss

(2010) Jun Yang et al.   PLoS Genetics

Extensions of PDZ domains as important structural and functional elements

(2010) Conan K. Wang et al.   Protein & Cell

Design and Synthesis of Highly Potent and Plasma-Stable Dimeric Inhibitors of the PSD-95-NMDA Receptor Interaction

(2009) Anders Bach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Scaffold Protein PDZK1 Undergoes a Head-to-Tail Intramolecular Association That Negatively Regulates Its Interaction with EBP50†

(2009) David P. LaLonde et al.   BIOCHEMISTRY

A Sequential Binding Mechanism in a PDZ Domain

(2009) Celestine N. Chi et al.   BIOCHEMISTRY

Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism

(2009) Karin Ellencrona et al.   BIOLOGICAL CHEMISTRY

The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain

(2009) Kris Meerschaert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Conformational Switch in the Scaffolding Protein NHERF1 Controls Autoinhibition and Complex Formation

(2009) Shibani Bhattacharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Dephosphorylation of the Syndecan-1 PDZ Binding Domain Regulates Syntenin-1 Recruitment

(2009) Béatrice Sulka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All-Atom Monte Carlo Approach to Protein–Peptide Binding

(2009) Iskra Staneva et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineered Symmetric Connectivity of Secondary Structure Elements Highlights Malleability of Protein Folding Pathways

(2009) Ylva Ivarsson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Wnt signaling by Dishevelled PDZ peptides

(2009) Yingnan Zhang et al.   Nature Chemical Biology

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

(2009) Wei Feng et al.   NATURE REVIEWS NEUROSCIENCE

Hidden dynamic allostery in a PDZ domain

(2009) C. M. Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of specificity and promiscuity of PDZ domain interactions through their dynamic behavior

(2009) Z. Nevin Gerek et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Rapid Evolution of Functional Complexity in a Domain Family

(2009) A. Ernst et al.   Science Signaling

Autoinhibitory Interactions between the PDZ2 and C-terminal Domains in the Scaffolding Protein NHERF1

(2009) Hong Cheng et al.   STRUCTURE

PTEN Acetylation Modulates Its Interaction with PDZ Domain

(2008) T. Ikenoue et al.   CANCER RESEARCH

Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites

(2008) Jia Chen et al.   EMBO JOURNAL

Par-3-mediated Junctional Localization of the Lipid Phosphatase PTEN Is Required for Cell Polarity Establishment

(2008) Wei Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pair of Circularly Permutated PDZ Domains Control RseP, the S2P Family Intramembrane Protease ofEscherichia coli

(2008) Kenji Inaba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ins and outs of syntenin, a multifunctional intracellular adaptor protein

(2008) J. M. Beekman et al.   JOURNAL OF CELL SCIENCE

Mapping of Two Networks of Residues That Exhibit Structural and Dynamical Changes upon Binding in a PDZ Domain Protein

(2008) Anne Dhulesia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Class III PDZ Binding Motif in the Myotilin and FATZ Families Binds Enigma Family Proteins: a Common Link for Z-Disc Myopathies

(2008) P. von Nandelstadh et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis for the regulated protease and chaperone function of DegP

(2008) Tobias Krojer et al.   NATURE

Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors

(2008) Clara L Essmann et al.   NATURE NEUROSCIENCE

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Design of protein function leaps by directed domain interface evolution

(2008) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

(2008) T. Krojer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The folding pathway of an engineered circularly permuted PDZ domain

(2008) Y. Ivarsson et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Signaling pathways of PDZ2 domain: A molecular dynamics interaction correlation analysis

(2008) Yifei Kong et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A Specificity Map for the PDZ Domain Family

(2008) Raffi Tonikian et al.   PLOS BIOLOGY