Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants

A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor

(2017) Joel Kooistra et al.   JOURNAL OF ALZHEIMERS DISEASE

Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer

(2016) Miroslaw Jarzab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Conserved Activation Cluster Is Required for Allosteric Communication in HtrA-Family Proteases

(2015) Anna K. de Regt et al.   STRUCTURE

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

(2015) Przemyslaw Glaza et al.   PLoS One

Dual regulatory switch confers tighter control on HtrA2 proteolytic activity

(2014) Nitu Singh et al.   FEBS Journal

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Intricate structural coordination and domain plasticity regulate activity of serine protease HtrA2

(2013) Lalith K. Chaganti et al.   FASEB JOURNAL

Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket

(2013) Pruthvi Raj Bejugam et al.   PLoS One

Temperature-induced changes of HtrA2(Omi) protease activity and structure

(2012) Dorota Zurawa-Janicka et al.   CELL STRESS & CHAPERONES

Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response

(2012) Guido Hansen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics

(2012) Levi C.T. Pierce et al.   Journal of Chemical Theory and Computation

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born

(2012) Andreas W. Götz et al.   Journal of Chemical Theory and Computation

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The structural basis of mode of activation and functional diversity: A case study with HtrA family of serine proteases

(2011) Nitu Singh et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages

(2011) Seokhee Kim et al.   CELL

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

(2011) Justyna Sawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HTRA proteases: regulated proteolysis in protein quality control

(2011) Tim Clausen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

(2011) Juliane Kley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate-induced remodeling of the active site regulates human HTRA1 activity

(2011) Linda Truebestein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies

(2011) R. Wrase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distance Mapping in Proteins Using Fluorescence Spectroscopy: The Tryptophan-Induced Quenching (TrIQ) Method

(2010) Steven E. Mansoor et al.   BIOCHEMISTRY

PDZ domains and their binding partners: structure, specificity, and modification

(2010) Ho-Jin Lee et al.   Cell Communication and Signaling

HtrA proteins as targets in therapy of cancer and other diseases

(2010) Dorota Zurawa-Janicka et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Allostery Is an Intrinsic Property of the Protease Domain of DegS

(2010) Jungsan Sohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Wilms' Tumor Suppressor Protein WT1 Is Processed by the Serine Protease HtrA2/Omi

(2010) Jörg Hartkamp et al.   MOLECULAR CELL

Mitochondrial Quality Control and Parkinson’s Disease: A Pathway Unfolds

(2010) Inês Pimenta de Castro et al.   MOLECULAR NEUROBIOLOGY

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

(2010) Tobias Krojer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Association of Omi/HtrA2 with γ-secretase in mitochondria

(2010) Homira Behbahani et al.   NEUROCHEMISTRY INTERNATIONAL

HtrA Serine Proteases as Potential Therapeutic Targets in Cancer

(2009) Jeremy Chien et al.   CURRENT CANCER DRUG TARGETS

Mitochondrial Serine Protease HtrA2/Omi as a Potential Therapeutic Target

(2009) Md. Bhuiyan et al.   CURRENT DRUG TARGETS

Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Structure and Function of the Virulence-Associated High-Temperature Requirement A ofMycobacterium tuberculosis†‡

(2008) Nilofar N. MohamedMohaideen et al.   BIOCHEMISTRY

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

(2008) N Moisoi et al.   CELL DEATH AND DIFFERENTIATION

Structural basis for the regulated protease and chaperone function of DegP

(2008) Tobias Krojer et al.   NATURE

Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease

(2008) S. Krick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins

(2008) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA