Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

(2012) Hélène Malet et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cage assembly of DegP protease is not required for substrate-dependent regulation of proteolytic activity or high-temperature cell survival

(2012) S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of mode of activation and functional diversity: A case study with HtrA family of serine proteases

(2011) Nitu Singh et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages

(2011) Seokhee Kim et al.   CELL

A Systematic Family-wide Investigation Reveals that ∼30% of Mammalian PDZ Domains Engage in PDZ-PDZ Interactions

(2011) Bryan H. Chang et al.   CHEMISTRY & BIOLOGY

Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

(2011) Justyna Sawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HtrA is a major virulence determinant of Bacillus anthracis

(2011) Theodor Chitlaru et al.   MOLECULAR MICROBIOLOGY

HTRA proteases: regulated proteolysis in protein quality control

(2011) Tim Clausen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

(2011) Juliane Kley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate-induced remodeling of the active site regulates human HTRA1 activity

(2011) Linda Truebestein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SMART 7: recent updates to the protein domain annotation resource

(2011) I. Letunic et al.   NUCLEIC ACIDS RESEARCH

Signal integration by DegS and RseB governs the σE-mediated envelope stress response inEscherichia coli

(2011) Rachna Chaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies

(2011) R. Wrase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the Structure and Function of Escherichia coli DegQ as a Representative of the DegQ-like Proteases of Bacterial HtrA Family Proteins

(2011) Xiao-chen Bai et al.   STRUCTURE

PDZ domains and their binding partners: structure, specificity, and modification

(2010) Ho-Jin Lee et al.   Cell Communication and Signaling

Molecular transformers in the cell: lessons learned from the DegP protease–chaperone

(2010) Justyna Sawa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

Allostery Is an Intrinsic Property of the Protease Domain of DegS

(2010) Jungsan Sohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conversion of a Regulatory into a Degradative Protease

(2010) Sonja Hasenbein et al.   JOURNAL OF MOLECULAR BIOLOGY

The Serine Protease HtrA1 Specifically Interacts and Degrades the Tuberous Sclerosis Complex 2 Protein

(2010) M. Campioni et al.   MOLECULAR CANCER RESEARCH

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

(2010) Tobias Krojer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extensions of PDZ domains as important structural and functional elements

(2010) Conan K. Wang et al.   Protein & Cell

HtrA Serine Proteases as Potential Therapeutic Targets in Cancer

(2009) Jeremy Chien et al.   CURRENT CANCER DRUG TARGETS

Role of DegP for two-partner secretion inBordetella

(2009) C. Baud et al.   MOLECULAR MICROBIOLOGY

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

(2009) Kenju Hara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control

(2009) Q.-T. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria

(2009) Pitter F. Huesgen et al.   RESEARCH IN MICROBIOLOGY

Proteases in bacterial pathogenesis

(2009) Hanne Ingmer et al.   RESEARCH IN MICROBIOLOGY

OMP Peptides Activate the DegS Stress-Sensor Protease by a Relief of Inhibition Mechanism

(2009) Jungsan Sohn et al.   STRUCTURE

Emerging roles of serine proteinases in tissue turnover in arthritis

(2008) J. M. Milner et al.   ARTHRITIS AND RHEUMATISM

Structure and Function of the Virulence-Associated High-Temperature Requirement A ofMycobacterium tuberculosis†‡

(2008) Nilofar N. MohamedMohaideen et al.   BIOCHEMISTRY

HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival

(2008) S Launay et al.   CELL DEATH AND DIFFERENTIATION

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

Evolution of Peptidase Diversity

(2008) Michael J. Page et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism of Temperature-Induced Bacterial HtrA Activation

(2008) Dong Young Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Age-related macular degeneration

(2008) Hanna R Coleman et al.   LANCET

Overproduction or Absence of the Periplasmic Protease DegP Severely Compromises Bacterial Growth in the Absence of the Dithiol: Disulfide Oxidoreductase DsbA

(2008) Özlem Önder et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural basis for the regulated protease and chaperone function of DegP

(2008) Tobias Krojer et al.   NATURE

D1-protein dynamics in photosystem II: the lingering enigma

(2008) Marvin Edelman et al.   PHOTOSYNTHESIS RESEARCH

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins

(2008) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

(2008) T. Krojer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Specificity Map for the PDZ Domain Family

(2008) Raffi Tonikian et al.   PLOS BIOLOGY