Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

HTRA3 is Reduced in Ovarian Cancers Regardless of Stage

(2014) M. Zhao et al.   CANCER INVESTIGATION

The LA Loop as an Important Regulatory Element of the HtrA (DegP) Protease fromEscherichia coli

(2014) Donata Figaj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HtrA Protease Family as Therapeutic Targets

(2013) Joanna Skorko-Glonek et al.   CURRENT PHARMACEUTICAL DESIGN

Application of the wheat-germ cell-free translation system to produce high temperature requirement A3 (HtrA3) proteases

(2012) Harmeet Singh et al.   BIOTECHNIQUES

Temperature-induced changes of HtrA2(Omi) protease activity and structure

(2012) Dorota Zurawa-Janicka et al.   CELL STRESS & CHAPERONES

Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response

(2012) Guido Hansen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HtrA3 as an Early Marker for Preeclampsia: Specific Monoclonal Antibodies and Sensitive High-Throughput Assays for Serum Screening

(2012) Kemperly Dynon et al.   PLoS One

Cage assembly of DegP protease is not required for substrate-dependent regulation of proteolytic activity or high-temperature cell survival

(2012) S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Analysis of HtrA1 and Its Subdomains

(2012) Charles Eigenbrot et al.   STRUCTURE

Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening

(2011) Fabrice Gorrec et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages

(2011) Seokhee Kim et al.   CELL

HTRA proteases: regulated proteolysis in protein quality control

(2011) Tim Clausen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substrate-induced remodeling of the active site regulates human HTRA1 activity

(2011) Linda Truebestein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies

(2011) R. Wrase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer

(2010) D. Beleford et al.   CLINICAL CANCER RESEARCH

High Temperature Requirement A3 (HtrA3) Promotes Etoposide- and Cisplatin-induced Cytotoxicity in Lung Cancer Cell Lines

(2010) Daniah Beleford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allostery Is an Intrinsic Property of the Protease Domain of DegS

(2010) Jungsan Sohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Placental HtrA3 Is Regulated by Oxygen Tension and Serum Levels Are Altered during Early Pregnancy in Women Destined to Develop Preeclampsia

(2010) Ying Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High-temperature requirement factor A3 (Htra3): A novel serine protease and its potential role in ovarian function and ovarian cancers

(2010) Marissa A. Bowden et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

(2010) Tobias Krojer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Inhibition of HTRA3 stimulates trophoblast invasion during human placental development

(2010) H. Singh et al.   PLACENTA

Structural basis of substrate specificity in the serine proteases

(2010) John J. Perona et al.   PROTEIN SCIENCE

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

HtrA Serine Proteases as Potential Therapeutic Targets in Cancer

(2009) Jeremy Chien et al.   CURRENT CANCER DRUG TARGETS

Structure and Function of the Virulence-Associated High-Temperature Requirement A ofMycobacterium tuberculosis†‡

(2008) Nilofar N. MohamedMohaideen et al.   BIOCHEMISTRY

Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer

(2008) Joanna Narkiewicz et al.   CLINICAL BIOCHEMISTRY

CHAINSAW: a program for mutating pdb files used as templates in molecular replacement

(2008) Norman Stein   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Structural basis for the regulated protease and chaperone function of DegP

(2008) Tobias Krojer et al.   NATURE

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins

(2008) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

(2008) T. Krojer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of Preeclampsia – A Workshop Report

(2007) N.G. Than et al.   PLACENTA