Recent Development in Carbohydrate Based Anticancer Vaccines

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Toward Automated Oligosaccharide Synthesis

(2011) Che-Hsiung Hsu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer

(2011) Brendan L. Wilkinson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Antitumor Vaccines Containing MUC1 Glycopeptides with Two Immunodominant Domains-Induction of a Strong Immune Response against Breast Tumor Tissues

(2011) Nikola Gaidzik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Synthesis and evaluation of protein conjugates of GM3 derivatives carrying modified sialic acids as highly immunogenic cancer vaccine candidates

(2011) Shichong Yu et al.   MedChemComm

Synthetic and Immunological Studies of sTn Derivatives Carrying Substituted Phenylacetylsialic Acids as Cancer Vaccine Candidate

(2011) Qianli Wang et al.   ACS Medicinal Chemistry Letters

Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen

(2010) Fan Yang et al.   ACS Chemical Biology

Synthetic Antitumor Vaccines from Tetanus Toxoid Conjugates of MUC1 Glycopeptides with the Thomsen-Friedenreich Antigen and a Fluorine-Substituted Analogue

(2010) Anja Hoffmann-Röder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fully Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptides and a Lipopeptide Ligand of the Toll-like Receptor 2

(2010) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stable GM3Lactone Mimetic Raises Antibodies Specific for the Antigens Expressed on Melanoma Cells

(2010) Annarosa Arcangeli et al.   BIOCONJUGATE CHEMISTRY

Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant

(2010) T. Freire et al.   BLOOD

Heterophilic NeuGcGM3 ganglioside cancer vaccine in advanced melanoma patients: Results of a phase Ib/IIa study

(2010) Marta Osorio et al.   CANCER BIOLOGY & THERAPY

Synthesis of MUC1–lipopeptide chimeras

(2010) Brendan L. Wilkinson et al.   CHEMICAL COMMUNICATIONS

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

Synthesis of a Single-Moleculel-Rhamnose-Containing Three-Component Vaccine and Evaluation of Antigenicity in the Presence of Anti-l-Rhamnose Antibodies

(2010) Sourav Sarkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Linear and Branched Glyco-Lipopeptide Vaccines Follow Distinct Cross-Presentation Pathways and Generate Different Magnitudes of Antitumor Immunity

(2010) Olivier Renaudet et al.   PLoS One

Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cells

(2010) Wei-Ming Lin et al.   VIRCHOWS ARCHIV

Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model

(2009) S Julien et al.   BRITISH JOURNAL OF CANCER

Increasing the Antigenicity of Synthetic Tumor-Associated Carbohydrate Antigens by Targeting Toll-Like Receptors

(2009) Sampat Ingale et al.   CHEMBIOCHEM

The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

(2009) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Breast cancer humoral immune response: involvement of Lewis y through the detection of circulating immune complexes and association with Mucin 1 (MUC1)

(2009) Marina Larrain et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Biologics through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn−PS A1 Conjugates

(2009) Ravindra A. De Silva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The cancer vaccine roller coaster

(2009) Bruce Goldman et al.   NATURE BIOTECHNOLOGY

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

‘Biologic’ level structures through chemistry: a total synthesis of a unimolecular pentavalent MUCI glycopeptide construct

(2009) Dongjoo Lee et al.   TETRAHEDRON LETTERS

Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes

(2008) Ilham Bettahi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cowpea Mosaic Virus Capsid: A Promising Carrier for the Development of Carbohydrate Based Antitumor Vaccines

(2008) Adeline Miermont et al.   CHEMISTRY-A EUROPEAN JOURNAL

Towards a Self-Adjuvanting Multivalent B and T cell Epitope Containing Synthetic Glycolipopeptide Cancer Vaccine

(2008) Olivier Renaudet et al.   ChemMedChem

Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis

(2008) W.-W. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA