Innate lymphoid cells as novel regulators of obesity and its-associated metabolic dysfunction

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

(2016) Andrew J. Murphy et al.   Cell Metabolism

Brown, Beige, and White: The New Color Code of Fat and Its Pharmacological Implications

(2015) Alexander Pfeifer et al.   Annual Review of Pharmacology and Toxicology

ICOS promotes group 2 innate lymphoid cell activation in lungs

(2015) Fumitaka Kamachi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

Innate lymphoid cells involve in tumorigenesis

(2015) Zhiqiang Tian et al.   INTERNATIONAL JOURNAL OF CANCER

Pivotal Roles of ILCs in Hepatic Diseases

(2015) Shuang Yang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Adipose tissue as an immunological organ

(2015) Ryan W. Grant et al.   Obesity

Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

(2015) Anne-Laure Poher et al.   Frontiers in Physiology

Group 2 innate lymphoid cells and CD4+T cells cooperate to mediate type 2 immune response in mice

(2014) L. Y. Drake et al.   ALLERGY

Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans

(2014) Takeshi Yoneshiro et al.   ANNALS OF MEDICINE

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance

(2014) Xavier S. Revelo et al.   DIABETES

MHC-II: A Mutual Support System for ILCs and T Cells?

(2014) Rick M. Maizels et al.   IMMUNITY

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

Transcription factors controlling development and function of innate lymphoid cells

(2014) Y. Tanriver et al.   INTERNATIONAL IMMUNOLOGY

20 YEARS OF LEPTIN: Connecting leptin signaling to biological function

(2014) Margaret B Allison et al.   JOURNAL OF ENDOCRINOLOGY

Composition of Innate Lymphoid Cell Subsets in the Human Skin: Enrichment of NCR + ILC3 in Lesional Skin and Blood of Psoriasis Patients

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

(2014) Sumaira Z Hasnain et al.   NATURE MEDICINE

Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity

(2014) Robert W. O'Rourke et al.   Obesity

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

(2014) Dorothy K Sojka et al.   eLife

Recognition Strategies of Group 3 Innate Lymphoid Cells

(2014) Monica Killig et al.   Frontiers in Immunology

FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases

(2014) Nobuyuki Itoh   Frontiers in Endocrinology

The Impact of Obesity on US Mortality Levels: The Importance of Age and Cohort Factors in Population Estimates

(2013) Ryan K. Masters et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Innate lymphoid cells in homeostasis, infection, chronic inflammation and tumors of the gastrointestinal tract

(2013) Anja Fuchs et al.   CURRENT OPINION IN GASTROENTEROLOGY

Development and function of group 2 innate lymphoid cells

(2013) Jennifer A Walker et al.   CURRENT OPINION IN IMMUNOLOGY

ILC1 Populations Join the Border Patrol

(2013) Kevin J. Maloy et al.   IMMUNITY

The Immune System as a Sensor of the Metabolic State

(2013) Justin I. Odegaard et al.   IMMUNITY

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Linking the microbiota and metabolic disease with lymphotoxin

(2013) Vaibhav Upadhyay et al.   INTERNATIONAL IMMUNOLOGY

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

(2013) Jan-Eric Turner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice

(2013) E. Hams et al.   JOURNAL OF IMMUNOLOGY

Critical Role of p38 and GATA3 in Natural Helper Cell Function

(2013) J.-i. Furusawa et al.   JOURNAL OF IMMUNOLOGY

Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ ILC3 in Psoriasis

(2013) Federica Villanova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Distinct populations of adipogenic and myogenic Myf5-lineage progenitors in white adipose tissues

(2013) Tizhong Shan et al.   JOURNAL OF LIPID RESEARCH

Adipose tissue NK cells manifest an activated phenotype in human obesity

(2013) Robert W. O’Rourke et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

(2013) Matthew R. Hepworth et al.   NATURE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

(2013) Jiqiu Wang et al.   NATURE CELL BIOLOGY

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

Activation of adipose tissue macrophages in obese mice does not require lymphocytes

(2013) James W. Behan et al.   Obesity

Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk

(2013) Nana-Maria Wagner et al.   Obesity

Fat cells directly sense temperature to activate thermogenesis

(2013) L. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

(2013) J. I. Odegaard et al.   SCIENCE

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Thymic stromal lymphopoietin: an immune cytokine gene associated with the metabolic syndrome and blood pressure in severe obesity

(2012) Valérie Turcot et al.   CLINICAL SCIENCE

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

(2012) Thomas Hoyler et al.   IMMUNITY

Natural killer T cells in adipose tissue prevent insulin resistance

(2012) Henk S. Schipper et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Lymphotoxin regulates commensal responses to enable diet-induced obesity

(2012) Vaibhav Upadhyay et al.   NATURE IMMUNOLOGY

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Interleukin-15 Treatment Induces Weight Loss Independent of Lymphocytes

(2012) Nicole G. Barra et al.   PLoS One

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

Role of Innate Lymphocytes in Infection and Inflammation

(2012) Shigeo Koyasu et al.   Frontiers in Immunology

Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity

(2011) J. L. Barlow et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice

(2011) N. G. Barra et al.   DIABETES OBESITY & METABOLISM

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice

(2010) Ashley M. Miller et al.   CIRCULATION RESEARCH

Cutting Edge: Thymic NK Cells Develop Independently from T Cell Precursors

(2010) V. S. G. Ribeiro et al.   JOURNAL OF IMMUNOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

(2009) Prospective Studies Collaboration   LANCET

Sensory and sympathetic nervous system control of white adipose tissue lipolysis

(2009) Timothy J. Bartness et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-15 Contributes to the Regulation of Murine Adipose Tissue and Human Adipocytes

(2009) Nicole G. Barra et al.   Obesity

Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass

(2008) Anders Rinnov Nielsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33 reduces the development of atherosclerosis

(2008) Ashley M. Miller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Gene–Environment Interactions in the Etiology of Obesity: Defining the Fundamentals

(2008) Claude Bouchard   Obesity

Effects of IL-15 on Rat Brown Adipose Tissue: Uncoupling Proteins and PPARs

(2008) Vanessa Almendro et al.   Obesity