Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition

Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation

(2015) Jinzhong Lin et al.   CELL

PEGylation of the peptide Bac7(1–35) reduces renal clearance while retaining antibacterial activity and bacterial cell penetration capacity

(2015) Monica Benincasa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of Size and N-Terminal Residue Characteristics on Bacterial Cell Penetration and Antibacterial Activity of the Proline-Rich Peptide Bac7

(2015) Filomena Guida et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics

(2015) Alexey Amunts et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

(2015) Yury S. Polikanov et al.   MOLECULAR CELL

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

(2015) A Carolin Seefeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin

(2015) Raktim N Roy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

(2015) A Carolin Seefeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin

(2015) Raktim N Roy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

(2014) Wenyi Li et al.   AMINO ACIDS

Insect-Derived Proline-Rich Antimicrobial Peptides Kill Bacteria by Inhibiting Bacterial Protein Translation at the 70 S Ribosome

(2014) Andor Krizsan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism of Escherichia coli Resistance to Pyrrhocoricin

(2014) S. Narayanan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Insect antimicrobial peptides and their applications

(2014) Hui-Yu Yi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Host Antimicrobial Peptide Bac71-35 Binds to Bacterial Ribosomal Proteins and Inhibits Protein Synthesis

(2014) Mario Mardirossian et al.   CHEMISTRY & BIOLOGY

Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA

(2014) Yury S. Polikanov et al.   MOLECULAR CELL

Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome

(2014) Yury S. Polikanov et al.   MOLECULAR CELL

Structural basis for the inhibition of the eukaryotic ribosome

(2014) Nicolas Garreau de Loubresse et al.   NATURE

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

(2014) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Macrolide antibiotics allosterically predispose the ribosome for translation arrest

(2014) Shanmugapriya Sothiselvam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7

(2014) Michael Zahn et al.   PROTEIN AND PEPTIDE LETTERS

Cellular Uptake of Apidaecin 1b and Related Analogs in Gram-negative Bacteria Reveals Novel Antibacterial Mechanism for Proline-rich Antimicrobial Peptides

(2014) Nicole Berthold et al.   PROTEIN AND PEPTIDE LETTERS

Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome

(2014) M. G. Gagnon et al.   SCIENCE

The Antibiotics Dityromycin and GE82832 Bind Protein S12 and Block EF-G-Catalyzed Translocation

(2014) David Bulkley et al.   Cell Reports

Tools for Characterizing Bacterial Protein Synthesis Inhibitors

(2013) Cédric Orelle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Characterization of SbmA, a Bacterial Inner Membrane Transporter Required for Importing the Antimicrobial Peptide Bac7(1-35)

(2013) G. Runti et al.   JOURNAL OF BACTERIOLOGY

Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK

(2013) Michael Zahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

(2013) Cédric Orelle et al.   NUCLEIC ACIDS RESEARCH

Selective Protein Synthesis by Ribosomes with a Drug-Obstructed Exit Tunnel

(2012) Krishna Kannan et al.   CELL

Elements of ribosomal drug resistance and specificity

(2012) Gregor M Blaha et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Antibiotic Thermorubin Inhibits Protein Synthesis by Binding to Inter-Subunit Bridge B2a of the Ribosome

(2012) David Bulkley et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome

(2012) M. G. Gagnon et al.   SCIENCE

How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis

(2012) Y. S. Polikanov et al.   SCIENCE

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action

(2011) Marco Scocchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex

(2011) Daniel Knappe et al.   CHEMBIOCHEM

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens

(2010) Daniel Knappe et al.   JOURNAL OF MEDICINAL CHEMISTRY

The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome

(2010) Robin E Stanley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

(2010) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the structures of several antibiotics bound to the bacterial ribosome

(2010) D. Bulkley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics that target protein synthesis

(2010) Lisa S. McCoy et al.   Wiley Interdisciplinary Reviews-RNA

U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

(2009) Güliz Gürel et al.   JOURNAL OF MOLECULAR BIOLOGY

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

(2009) Rebecca M Voorhees et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Essential Role for the BacA Protein in the Uptake of a Truncated Eukaryotic Peptide in Sinorhizobium meliloti

(2008) V. L. Marlow et al.   JOURNAL OF BACTERIOLOGY

Molecular Mechanism of Drug-Dependent Ribosome Stalling

(2008) Nora Vazquez-Laslop et al.   MOLECULAR CELL