Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development

From sentencing to execution – the processes of apoptosis

(2015) Kelly L. Moffitt et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

2011 Alzheimer’s disease facts and figures

(2011)   Alzheimers & Dementia

The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease

(2011) Aristotle N. Voineskos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

(2011) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Mammalian Target of Rapamycin (mTOR) Inhibitors

(2011) Sofia Sofroniadou et al.   DRUG SAFETY

Altered palmitoylation and neuropathological deficits in mice lacking HIP14

(2011) R. R. Singaraja et al.   HUMAN MOLECULAR GENETICS

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14

(2011) Kun Huang et al.   HUMAN MOLECULAR GENETICS

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

(2011) U. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Huntington's Disease: Effect of Memantine on FDG-PET Brain Metabolism?

(2011) L. E. Hjermind et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease

(2011) Baris Bingol et al.   NEURON

Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer’s disease

(2011) Mohammed Filali et al.   NEUROPHARMACOLOGY

Gene Therapy in Mouse Models of Huntington Disease

(2011) Amber L. Southwell et al.   NEUROSCIENTIST

A Phase II Multi-Center Study of Triple Therapy with Paclitaxel, S-1 and Cisplatin in Patients with Advanced Gastric Cancer

(2011) H. Iwase et al.   ONCOLOGY

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy

(2010) Domenico Praticò   Annals of the New York Academy of Sciences

Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants

(2010) Edward C. Stack et al.   Annals of the New York Academy of Sciences

Beclin 1 Complex in Autophagy and Alzheimer Disease

(2010) Philipp A. Jaeger et al.   ARCHIVES OF NEUROLOGY

Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease

(2010) Nicholas D. Dey et al.   BEHAVIOURAL BRAIN RESEARCH

Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation

(2010) Hui-li Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

(2010) Daniel C. Gray et al.   CELL

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis

(2010) Derliz Mereles et al.   Clinical Research in Cardiology

The Physiological Relevance of Protein Phosphatase 1 and its Interacting Proteins to Health and Disease

(2010) M. Fardilha et al.   CURRENT MEDICINAL CHEMISTRY

The clinical development of histone deacetylase inhibitors as targeted anticancer drugs

(2010) Paul A Marks   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Advances and perspectives from genetic research: development of biological markers in Alzheimer’s disease

(2010) Thomas Zetzsche et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Nanolipidic particles improve the bioavailability and α-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease

(2010) Adam Smith et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role - relevance for Alzheimer pathology

(2010) Gennaro Schettini et al.   JOURNAL OF NEUROCHEMISTRY

Convergence of Presenilin- and Tau-Mediated Pathways on Axonal Trafficking and Neuronal Function

(2010) E. Peethumnongsin et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Huntingtin at Ser421 in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A

(2010) M. Metzler et al.   JOURNAL OF NEUROSCIENCE

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

(2010) K. R. Brunden et al.   JOURNAL OF NEUROSCIENCE

Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

(2010) D. Halawani et al.   JOURNAL OF NEUROSCIENCE

Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo

(2010) R. K. Graham et al.   JOURNAL OF NEUROSCIENCE

Axonal Degeneration Is Regulated by the Apoptotic Machinery or a NAD+-Sensitive Pathway in Insects and Mammals

(2010) Z. Schoenmann et al.   JOURNAL OF NEUROSCIENCE

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

(2010) Sarah J Tabrizi et al.   LANCET NEUROLOGY

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

(2010) Katya J Park et al.   NATURE NEUROSCIENCE

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease

(2010) Tyisha Hathorn et al.   NEUROBIOLOGY OF DISEASE

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

Novel Insights into Lithium’s Mechanism of Action: Neurotrophic and Neuroprotective Effects

(2010) Jorge A. Quiroz et al.   NEUROPSYCHOBIOLOGY

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor

(2010) Roni Scherzer-Attali et al.   PLoS One

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of Amyloid: Structure, Function, and Regulation

(2010) Jason Greenwald et al.   STRUCTURE

Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons

(2010) Jian-Li Hu et al.   Molecular Brain

Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75NTRinteraction

(2009) Joanna Fombonne et al.   ANNALS OF NEUROLOGY

Can’t live without them, can live with them: roles of caspases during vital cellular processes

(2009) Yael Feinstein-Rotkopf et al.   APOPTOSIS

Development of a Non Invasive NGF-Based Therapy for Alzheimers Disease

(2009) Sonia Covaceuszach et al.   Current Alzheimer Research

Early Diagnosis of Alzheimers Disease: Is MCI Too Late?

(2009) Ronald Petersen   Current Alzheimer Research

Mouse models of Huntington disease: variations on a theme

(2009) D. E. Ehrnhoefer et al.   Disease Models & Mechanisms

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity

(2009) Kun Huang et al.   FASEB JOURNAL

Huntingtin-associated Protein-1 Interacts with Pro-brain-derived Neurotrophic Factor and Mediates Its Transport and Release

(2009) Linda Lin-yan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity

(2009) Hyang-Sook Hoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Apoptosis and cancer: mutations within caspase genes

(2009) S Ghavami et al.   JOURNAL OF MEDICAL GENETICS

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Mutant huntingtin and glycogen synthase kinase 3-β accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease

(2009) Antonio Valencia et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

(2009) Daniel del Toro et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

(2009) E M Toledo et al.   MOLECULAR PSYCHIATRY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Recombinant human NGF-loaded microspheres promote survival of basal forebrain cholinergic neurons and improve memory impairments of spatial learning in the rat model of Alzheimer's disease with fimbria-fornix lesion

(2009) Haigang Gu et al.   NEUROSCIENCE LETTERS

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

(2009) D. A. Simmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

(2008) Kavon Rezai-Zadeh et al.   BRAIN RESEARCH

Neurotrophins - From Pathophysiology to Treatment in Alzheimers Disease

(2008) Rainer Hellweg et al.   Current Alzheimer Research

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

(2008) Haipeng Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease

(2008) Siddhartha Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice

(2008) Jianjun Wang et al.   JOURNAL OF CELL BIOLOGY

The ubiquitin-proteasome system in Alzheimer's disease

(2008) Salvatore Oddo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

(2008) Simon C. Warby et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats

(2008) S. Arancibia et al.   NEUROBIOLOGY OF DISEASE

Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect

(2008) F. Jeanneteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE