Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

Is Tau Aggregation Toxic or Protective?

(2017) Erin E. Congdon et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of Response Properties and Operating Range of the AFD Thermosensory Neurons by cGMP Signaling

(2011) Sara M. Wasserman et al.   CURRENT BIOLOGY

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation

(2011) Surendra S. Ambegaokar et al.   HUMAN MOLECULAR GENETICS

Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila

(2011) Yasmina Talmat-Amar et al.   HUMAN MOLECULAR GENETICS

Are Tangles as Toxic as They Look?

(2011) Tara L. Spires-Jones et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Optogenetic analysis of GABAB receptor signaling in Caenorhabditis elegans motor neurons

(2011) Christian Schultheis et al.   JOURNAL OF NEUROPHYSIOLOGY

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

“Lest we forget you — methylene blue …”

(2011) R. Heiner Schirmer et al.   NEUROBIOLOGY OF AGING

Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology

(2011) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Towards a Pharmacophore for Amyloid

(2011) Meytal Landau et al.   PLOS BIOLOGY

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

(2011) M. Catarina Silva et al.   PLoS Genetics

Tau, prions and Aβ: the triad of neurodegeneration

(2010) Lilla Reiniger et al.   ACTA NEUROPATHOLOGICA

Phosphorylation differentiates tau-dependent neuronal toxicity and dysfunction

(2010) Katerina Papanikolopoulou et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?

(2010) Jeanna M. Wheeler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial: Figure 1

(2010) Khalid Iqbal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Methylene Blue Reduces Aβ Levels and Rescues Early Cognitive Deficit by Increasing Proteasome Activity

(2010) David X. Medina et al.   BRAIN PATHOLOGY

High-throughput screening and small animal models, where are we?

(2010) Jean Giacomotto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of aggregate formation as therapeutic target in protein misfolding diseases: effect of tetracycline and trehalose

(2010) Ivana Sirangelo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mysterious oligomerization of the amyloidogenic proteins

(2010) Vladimir N. Uversky   FEBS Journal

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

(2010) J. N. Sleigh et al.   HUMAN MOLECULAR GENETICS

Discovery of Brain-Penetrant, Orally Bioavailable Aminothienopyridazine Inhibitors of Tau Aggregation

(2010) Carlo Ballatore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Effects of Tau on the Integrity and Function of Neurons Essential for Learning in Drosophila

(2010) S. Kosmidis et al.   JOURNAL OF NEUROSCIENCE

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

(2010) Andrew R Burns et al.   Nature Chemical Biology

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers

(2010) Luisa Diomede et al.   NEUROBIOLOGY OF DISEASE

Chaperone networks: Tipping the balance in protein folding diseases

(2010) Cindy Voisine et al.   NEUROBIOLOGY OF DISEASE

An Arf-like Small G Protein, ARL-8, Promotes the Axonal Transport of Presynaptic Cargoes by Suppressing Vesicle Aggregation

(2010) Matthew P. Klassen et al.   NEURON

Tau protein and tau aggregation inhibitors

(2010) Bruno Bulic et al.   NEUROPHARMACOLOGY

Ageing and protein aggregation-mediated disorders: from invertebrates to mammals

(2010) A. Dillin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration

(2010) L. R. Earls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans

(2009) Chris R. Guthrie et al.   HUMAN MOLECULAR GENETICS

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

(2009) Dominik Paquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

(2009) Alicia N Minniti et al.   Molecular Neurodegeneration

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

The invertebrate microtubule-associated protein PTL-1 functions in mechanosensation and development in Caenorhabditis elegans

(2008) Patricia Gordon et al.   DEVELOPMENT GENES AND EVOLUTION

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE

The insulin paradox: aging, proteotoxicity and neurodegeneration

(2008) Ehud Cohen et al.   NATURE REVIEWS NEUROSCIENCE

Tau-based treatment strategies in neurodegenerative diseases

(2008) Anja Schneider et al.   Neurotherapeutics

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

(2008) L. M. Ittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

(2008) Serena Deiana et al.   PSYCHOPHARMACOLOGY

A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

(2007) Roland Brandt et al.   NEUROBIOLOGY OF AGING