Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

Behavioral Phenotyping of a Transgenic Caenorhabditis Elegans Expressing Neuronal Amyloid-β

(2017) Laura E. Dosanjh et al.   JOURNAL OF ALZHEIMERS DISEASE

Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway

(2015) Shashi Kant Tiwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease

(2015) Jinghua Liu et al.   Marine Drugs

Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression

(2015) Xi Chen et al.   Molecular Neurodegeneration

Carqueja (Baccharis trimera) Protects against Oxidative Stress andβ-Amyloid-Induced Toxicity inCaenorhabditis elegans

(2015) Franciny Aparecida Paiva et al.   Oxidative Medicine and Cellular Longevity

Cysteine string protein (CSP) and its role in preventing neurodegeneration

(2015) Robert D. Burgoyne et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neuroprotective effects of dietary restriction: Evidence and mechanisms

(2015) Giovambattista Pani   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components

(2015) Hannah V. McCue et al.   Scientific Reports

Spermidine protects against α-synuclein neurotoxicity

(2014) Sabrina Büttner et al.   CELL CYCLE

Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol

(2014) Sudhanva S. Kashyap et al.   HUMAN MOLECULAR GENETICS

Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress

(2014) Lingyun Xiao et al.   MOLECULES

n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease

(2014) Ru-Huei Fu et al.   PLoS One

Novel Polyglutamine Model Uncouples Proteotoxicity from Aging

(2014) Nakeirah T. M. Christie et al.   PLoS One

Clioquinol promotes the degradation of metal-dependent amyloid-  (A ) oligomers to restore endocytosis and ameliorate A  toxicity

(2014) K. E. S. Matlack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis

(2013) Jia Li et al.   ACTA PHARMACOLOGICA SINICA

CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration

(2013) Nicole F. Liachko et al.   ANNALS OF NEUROLOGY

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Exciting Prospects for Precise Engineering of Caenorhabditis elegans Genomes with CRISPR/Cas9

(2013) Christian Frøkjær-Jensen   GENETICS

Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity

(2013) Arnaud Tauffenberger et al.   NEUROBIOLOGY OF AGING

Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease

(2013) Ru-Huei Fu et al.   NEUROPHARMACOLOGY

Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling

(2013) Bwarenaba B. Kautu et al.   NEUROSCIENCE LETTERS

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

(2013) Luisa Diomede et al.   PLoS One

Pharmacological Activation of Sirt1 Ameliorates Polyglutamine-Induced Toxicity through the Regulation of Autophagy

(2013) Bae Hyun Shin et al.   PLoS One

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

(2013) Carmen I. Nussbaum-Krammer et al.   PLoS Genetics

Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans

(2012) Srinivas Ayyadevara et al.   ANTIOXIDANTS & REDOX SIGNALING

The neuronal ceroid-lipofuscinoses: A historical introduction

(2012) Matti Haltia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dopamine D2 Receptor Antagonism Suppresses Tau Aggregation and Neurotoxicity

(2012) Allyson V. McCormick et al.   BIOLOGICAL PSYCHIATRY

Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms

(2012) Xi Chen et al.   BMC GENOMICS

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons

(2012) François-Xavier Lejeune et al.   BMC GENOMICS

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Neurotransmitter release mechanisms studied in Caenorhabditis elegans

(2012) Jeff W. Barclay et al.   CELL CALCIUM

Recurrent mutations inDNAJC5cause autosomal dominant Kufs disease

(2012) M Cadieux-Dion et al.   CLINICAL GENETICS

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

(2012) Chronis Fatouros et al.   HUMAN MOLECULAR GENETICS

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

(2012) C. Yao et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property inCaenorhabditis elegans

(2012) Tomoki Kuwahara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neuroprotective and lifespan-extension activities of Damnacanthus officinarum extracts in Caenorhabditis elegans

(2012) Xiliang Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pan-Neuronal Expression of APL-1, an APP-Related Protein, Disrupts Olfactory, Gustatory, and Touch Plasticity in Caenorhabditis elegans

(2012) C. Y. Ewald et al.   JOURNAL OF NEUROSCIENCE

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

(2012) Gawain McColl et al.   Molecular Neurodegeneration

Mutations in the Gene DNAJC5 Cause Autosomal Dominant Kufs Disease in a Proportion of Cases: Study of the Parry Family and 8 Other Families

(2012) Milen Velinov et al.   PLoS One

Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio

(2012) Alexandra Vaccaro et al.   PLoS One

Liuwei Dihuang (LWDH), a Traditional Chinese Medicinal Formula, Protects against β-Amyloid Toxicity in Transgenic Caenorhabditis elegans

(2012) Jatinder S. Sangha et al.   PLoS One

Forward Genetic Analysis to Identify Determinants of Dopamine Signaling in Caenorhabditis elegans Using Swimming-Induced Paralysis

(2012) J. Andrew Hardaway et al.   G3-Genes Genomes Genetics

Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity

(2011) Tsui-Ting Ching et al.   AGING CELL

Mutations in DNAJC5, Encoding Cysteine-String Protein Alpha, Cause Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis

(2011) Lenka Nosková et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease

(2011) D. F.F. Silva et al.   Current Alzheimer Research

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling

(2011) Tao Zhang et al.   HUMAN MOLECULAR GENETICS

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways

(2011) Andreia Teixeira-Castro et al.   HUMAN MOLECULAR GENETICS

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

(2011) Zhaohui Liu et al.   HUMAN MOLECULAR GENETICS

The Novel Hydroxylamine Derivative NG-094 Suppresses Polyglutamine Protein Toxicity inCaenorhabditis elegans

(2011) Pierre Haldimann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms

(2011) Daniel F. Tardiff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development

(2011) Dagmar E. Ehrnhoefer et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Phenolic Compounds Against Aβ Aggregation and Aβ-Induced Toxicity in Transgenic C. elegans

(2011) Seema Jagota et al.   NEUROCHEMICAL RESEARCH

Icariin and its Derivative Icariside II Extend Healthspan via Insulin/IGF-1 Pathway in C. elegans

(2011) Wai-Jiao Cai et al.   PLoS One

Exome-Sequencing Confirms DNAJC5 Mutations as Cause of Adult Neuronal Ceroid-Lipofuscinosis

(2011) Bruno A. Benitez et al.   PLoS One

FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity

(2011) Alex Lublin et al.   PLoS One

Prion protein inCaenorhabditis elegans

(2011) Kyung-Won Park et al.   Prion

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

Special Anniversary Review: Twenty-five years of human immunodeficiency virus research: successes and challenges

(2010) R. A. Weiss   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis elegans Model of  -Amyloid Peptide Toxicity

(2010) V. Dostal et al.   GENETICS

Neurotoxic effects of TDP-43 overexpression in C. elegans

(2010) Peter E.A. Ash et al.   HUMAN MOLECULAR GENETICS

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

(2010) J. N. Sleigh et al.   HUMAN MOLECULAR GENETICS

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Neuron Dysfunction Is Induced by Prion Protein with an Insertional Mutation via a Fyn Kinase and Reversed by Sirtuin Activation in Caenorhabditis elegans

(2010) N. Bizat et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy

(2010) N. F. Liachko et al.   JOURNAL OF NEUROSCIENCE

Resveratrol, sirtuins, and the promise of a DR mimetic

(2010) Joseph A. Baur   MECHANISMS OF AGEING AND DEVELOPMENT

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

(2010) Andrew R Burns et al.   Nature Chemical Biology

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers

(2010) Luisa Diomede et al.   NEUROBIOLOGY OF DISEASE

LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease

(2010) Chen Yao et al.   NEUROBIOLOGY OF DISEASE

Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans

(2010) Roongpetch Keowkase et al.   NEUROPHARMACOLOGY

Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway

(2010) S. Abbas et al.   PHYTOMEDICINE

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms

(2009) Tjakko J. van Ham et al.   EMBO Molecular Medicine

Reserpine ameliorates Aβ toxicity in the Alzheimer’s disease model in Caenorhabditis elegans

(2009) Upasna Arya et al.   EXPERIMENTAL GERONTOLOGY

Caenorhabditits elegansLRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth

(2009) Julia Sämann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

(2009) S. Saha et al.   JOURNAL OF NEUROSCIENCE

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease

(2009) Qingmin Ruan et al.   NEUROBIOLOGY OF DISEASE

Investigating Bacterial Sources of Toxicity as an Environmental Contributor to Dopaminergic Neurodegeneration

(2009) Kim A. Caldwell et al.   PLoS One

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

(2009) Tali Gidalevitz et al.   PLoS Genetics

Protein Misfolding and Neurodegeneration

(2008) Claudio Soto et al.   ARCHIVES OF NEUROLOGY

Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation

(2008) Heidrun Witan et al.   HUMAN MOLECULAR GENETICS

Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan

(2008) M. Briese et al.   HUMAN MOLECULAR GENETICS

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

(2008) Tomoki Kuwahara et al.   HUMAN MOLECULAR GENETICS

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL

Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease

(2008) Cody J. Locke et al.   NEUROSCIENCE LETTERS

Epigallocatechin Gallate from Green Tea (Camellia sinensis) Increases Lifespan and Stress Resistance inCaenorhabditis elegans

(2008) Sami Abbas et al.   PLANTA MEDICA

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics

A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

(2007) Roland Brandt et al.   NEUROBIOLOGY OF AGING