The Application of Bio-orthogonality for In Vivo Animal Imaging

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

(2023) Yang Yang et al.   ACTA NEUROPATHOLOGICA

Practical Guidance for Developing Small-Molecule Optical Probes for In Vivo Imaging

(2023) Chongzhao Ran et al.   MOLECULAR IMAGING AND BIOLOGY

De novo design of luciferases using deep learning

(2023) Andy Hsien-Wei Yeh et al.   NATURE

Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates

(2023) Yong Wang et al.   Nature Communications

Stimuli-Responsive Macrocyclization Scaffold Allows In Situ Self-Assembly of Radioactive Tracers for Positron Emission Tomography Imaging of Enzyme Activity

(2022) Jianguo Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Nanoparticle’s Journey to the Tumor: Strategies to Overcome First-Pass Metabolism and Their Limitations

(2022) Joshua J. Milligan et al.   Cancers

Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance

(2022) Aiyan Ji et al.   Nature Communications

Bioorthogonally activatable cyanine dye with torsion-induced disaggregation for in vivo tumor imaging

(2022) Xianghan Zhang et al.   Nature Communications

The Nobel Prize in Chemistry 2022: Fulfilling Demanding Applications with Simple Reactions

(2022) Peng Wu   ACS Chemical Biology

Bioorthogonal Lanthanide Molecular Probes for Near‐Infrared Fluorescence and Mass Spectrometry Imaging

(2022) Guo‐Qing Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis

(2022) Yingying Ning et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment

(2022) Yingying Ning et al.   Science Translational Medicine

First clinical applications for the NIR-II imaging with ICG in microsurgery

(2022) Yifan Wu et al.   Frontiers in Bioengineering and Biotechnology

Bio-orthogonal Metabolic Fluorine Labeling Enables Deep-Tissue Visualization of Tumor Cells In Vivo by 19F Magnetic Resonance Imaging

(2022) Dongxia Chen et al.   Analytical Chemistry

In vivo bioorthogonal labeling of rare-earth doped nanoparticles for improved NIR-II tumor imaging by extracellular vesicle-mediated targeting

(2022) Hui Li et al.   Nano Research

Tetrazine bioorthogonal chemistry derived in vivo imaging

(2022) Gaoxiang Zhao et al.   Frontiers in Molecular Biosciences

Influencing factors and strategies of enhancing nanoparticles into tumors in vivo

(2021) Mingming Zhang et al.   Acta Pharmaceutica Sinica B

IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications

(2021) Maryana Handula et al.   MOLECULES

Orthogonal synthesis and modification of polymer materials

(2021) Ali Shahrokhinia et al.   JOURNAL OF POLYMER SCIENCE

Bioorthogonal Ligation‐Activated Fluorogenic FRET Dyads

(2021) Evelin Albitz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry and Its Applications

(2021) Robert E. Bird et al.   BIOCONJUGATE CHEMISTRY

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential

(2020) Arkadiy A. Bazhin et al.   Nature Chemical Biology

Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo

(2020) Jing Yang et al.   Nature Communications

Transgenic Animal Models to Visualize Cancer-Related Cellular Processes by Bioluminescence Imaging

(2019) Isabella Manni et al.   Frontiers in Pharmacology

Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

(2019) Vangelis Agouridas et al.   CHEMICAL REVIEWS

A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging

(2019) Yuyan Jiang et al.   Nature Communications

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

(2019) Marius Kollmer et al.   Nature Communications

Bioorthogonal “Labeling after Recognition” Affording an FRET-Based Luminescent Probe for Detecting and Imaging Caspase-3 via Photoluminescence Lifetime Imaging

(2019) Qi Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles

(2018) Haoxing Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Pretargeted Immuno-PET Based on Bioorthogonal Chemistry for Imaging EGFR Positive Colorectal Cancer

(2018) Xudong Shi et al.   BIOCONJUGATE CHEMISTRY

Bioorthogonal chemistry in bioluminescence imaging

(2018) Aurélien Godinat et al.   DRUG DISCOVERY TODAY

15N4-1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthingpara-N2

(2018) Junu Bae et al.   Science Advances

Organic Semiconducting Agents for Deep-Tissue Molecular Imaging: Second Near-Infrared Fluorescence, Self-Luminescence, and Photoacoustics

(2018) Qingqing Miao et al.   ADVANCED MATERIALS

Pretargeted Imaging and Therapy

(2017) Mohamed Altai et al.   JOURNAL OF NUCLEAR MEDICINE

Orthogonal Luciferase–Luciferin Pairs for Bioluminescence Imaging

(2017) Krysten A. Jones et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aryl Fluorosulfate Trapped Staudinger Reduction

(2017) Gerui Ren et al.   ORGANIC LETTERS

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications

(2017) Laura Mezzanotte et al.   TRENDS IN BIOTECHNOLOGY

Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models

(2017) Outi Keinänen et al.   EJNMMI Research

Parallel Screening for Rapid Identification of Orthogonal Bioluminescent Tools

(2017) Colin M. Rathbun et al.   ACS Central Science

A Bioorthogonal Near-Infrared Fluorogenic Probe for mRNA Detection

(2016) Haoxing Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging

(2015) André A. Neves et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry

(2015) Paresh Agarwal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

On the design of highly luminescent lanthanide complexes

(2015) Jean-Claude G. Bünzli   COORDINATION CHEMISTRY REVIEWS

A small-molecule dye for NIR-II imaging

(2015) Alexander L. Antaris et al.   NATURE MATERIALS

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

(2014) Jiajia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hyperpolarized Magnetic Resonance as a Sensitive Detector of Metabolic Function

(2014) Arnaud Comment et al.   BIOCHEMISTRY

Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo

(2014) Deju Ye et al.   Nature Chemistry

Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes

(2014) P. Shieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation

(2014) Ampofo Darko et al.   Chemical Science

Bioorthogonal chemistry in living organisms

(2014) Annika Borrmann et al.   Chemical Science

A Biocompatible in Vivo Ligation Reaction and Its Application for Noninvasive Bioluminescent Imaging of Protease Activity in Living Mice

(2013) Aurélien Godinat et al.   ACS Chemical Biology

BODIPY-Tetrazine Derivatives as Superbright Bioorthogonal Turn-on Probes

(2013) Jonathan C. T. Carlson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry

(2013) B. M. Zeglis et al.   JOURNAL OF NUCLEAR MEDICINE

Reactive polymer enables efficient in vivo bioorthogonal chemistry

(2012) N. K. Devaraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Photoinducible Bioorthogonal Chemistry: A Spatiotemporally Controllable Tool to Visualize and Perturb Proteins in Live Cells

(2011) Reyna K. V. Lim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hyperpolarized Magnetic Resonance

(2011) Marie A. Schroeder et al.   CIRCULATION

Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation

(2011) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-Conjugated Small Molecule FRET for Differentiating Monomers from Higher Molecular Weight Amyloid Beta Species

(2011) Chongzhao Ran et al.   PLoS One

In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice

(2010) Raffaella Rossin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Real-Time Bioluminescence Imaging of Glycans on Live Cells

(2010) Allison S. Cohen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

(2009) Hongjun Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules

(2009) Michael D. Best   BIOCHEMISTRY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY