Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models

In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme

(2017) James C. Knight et al.   MOLECULAR PHARMACEUTICS

Micro-flow photosynthesis of new dienophiles for inverse-electron-demand Diels–Alder reactions. Potential applications for pretargeted in vivo PET imaging

(2017) Emilie M. F. Billaud et al.   Chemical Science

Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry

(2016) Shuang Hou et al.   ACS Nano

Click Chemistry and Radiochemistry: The First 10 Years

(2016) Jan-Philip Meyer et al.   BIOCONJUGATE CHEMISTRY

Pretargeted PET Imaging Using a Site-Specifically Labeled Immunoconjugate

(2016) Brendon E. Cook et al.   BIOCONJUGATE CHEMISTRY

Design, Synthesis, and Evaluation of a Low-Molecular-Weight 11C-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry

(2016) Christoph Denk et al.   BIOCONJUGATE CHEMISTRY

99mTc-bioorthogonal click chemistry reagent for in vivo pretargeted imaging

(2016) María Fernanda García et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines

(2016) Abdolreza Yazdani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a novel antibody–tetrazine conjugate for bioorthogonal pretargeting

(2016) Agnese Maggi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of 18F-PET Probes via Tetrazine Ligation

(2016) Mengzhe Wang et al.   Theranostics

Enhancing Reactivity for Bioorthogonal Pretargeting by Unmasking Antibody-Conjugated trans-Cyclooctenes

(2015) Maha K. Rahim et al.   BIOCONJUGATE CHEMISTRY

18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry

(2015) Jan-Philip Meyer et al.   BIOCONJUGATE CHEMISTRY

Pretargeted Immuno-PET of Pancreatic Cancer: Overcoming Circulating Antigen and Internalized Antibody to Reduce Radiation Doses

(2015) J. L. Houghton et al.   JOURNAL OF NUCLEAR MEDICINE

Diabody Pretargeting with Click Chemistry In Vivo

(2015) S. M. J. van Duijnhoven et al.   JOURNAL OF NUCLEAR MEDICINE

Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging

(2015) Heather E. Murrey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ideal Bioorthogonal Reactions Using A Site-Specifically Encoded Tetrazine Amino Acid

(2015) Robert J. Blizzard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma via the Modulation of Radioligand Pharmacokinetics

(2015) Brian M. Zeglis et al.   MOLECULAR PHARMACEUTICS

A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging

(2015) Outi Keinänen et al.   ACS Medicinal Chemistry Letters

A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging

(2014) Helen L. Evans et al.   CHEMICAL COMMUNICATIONS

Trans-Cyclooctene Tag with Improved Properties for Tumor Pretargeting with the Diels–Alder Reaction

(2014) Raffaella Rossin et al.   MOLECULAR PHARMACEUTICS

In vivo evaluation of 18F-labeled TCO for pre-targeted PET imaging in the brain

(2014) Leonie wyffels et al.   NUCLEAR MEDICINE AND BIOLOGY

Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation

(2014) Ampofo Darko et al.   Chemical Science

Applying PET to Broaden the Diagnostic Utility of the Clinically Validated CA19.9 Serum Biomarker for Oncology

(2013) N. T. Viola-Villegas et al.   JOURNAL OF NUCLEAR MEDICINE

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry

(2013) B. M. Zeglis et al.   JOURNAL OF NUCLEAR MEDICINE

Diels-Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody

(2013) R. Rossin et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging EGFR and HER2 by PET and SPECT: A Review

(2013) Emily B. Corcoran et al.   MEDICINAL RESEARCH REVIEWS

DOTAGA-Trastuzumab. A New Antibody Conjugate Targeting HER2/Neu Antigen for Diagnostic Purposes

(2012) Mathieu Moreau et al.   BIOCONJUGATE CHEMISTRY

A New Tri-Fab Bispecific Antibody for Pretargeting Trop-2-Expressing Epithelial Cancers

(2012) R. M. Sharkey et al.   JOURNAL OF NUCLEAR MEDICINE

Reactive polymer enables efficient in vivo bioorthogonal chemistry

(2012) N. K. Devaraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry

(2011) Brian M. Zeglis et al.   BIOCONJUGATE CHEMISTRY

Human Monoclonal Antibodies to Sialyl-Lewisa (CA19.9) with Potent CDC, ADCC, and Antitumor Activity

(2011) R. Sawada et al.   CLINICAL CANCER RESEARCH

Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine–trans-Cyclooctene Ligation

(2011) Michael T. Taylor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice

(2010) Raffaella Rossin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

(2010) Zibo Li et al.   CHEMICAL COMMUNICATIONS

Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

(2010) Göstring   INTERNATIONAL JOURNAL OF ONCOLOGY

Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging

(2010) Kelly Davis Orcutt et al.   NUCLEAR MEDICINE AND BIOLOGY

Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using 89Zr-DFO-Trastuzumab

(2010) Jason P. Holland et al.   PLoS One

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Standardized methods for the production of high specific-activity zirconium-89

(2009) Jason P. Holland et al.   NUCLEAR MEDICINE AND BIOLOGY

Influence of the Molecular Charge on the Biodistribution of Bombesin Analogues Labeled with the [99mTc(CO)3]-Core

(2008) Elisa García Garayoa et al.   BIOCONJUGATE CHEMISTRY

Receptor-Binding, Biodistribution, and Metabolism Studies of 64Cu-DOTA-Cetuximab, a PET-Imaging Agent for Epidermal Growth-Factor Receptor-Positive Tumors

(2008) Wen Ping Li et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

A33 antigen displays persistent surface expression

(2008) Margaret E. Ackerman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The biological properties of cetuximab

(2008) Bruno Vincenzi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY