Bioorthogonal chemistry in living organisms

Mesoporous Silica Nanoparticle Pretargeting for PET Imaging Based on a Rapid Bioorthogonal Reaction in a Living Body

(2013) Sang Bong Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry

(2013) Andrea Niederwieser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Profiling and Visualization of Cellular Protein-Lipid Interactions Using Bifunctional Fatty Acids

(2013) Per Haberkant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Imaging Cell Surface Glycosylation in Vivo Using “Double Click” Chemistry

(2013) André A. Neves et al.   BIOCONJUGATE CHEMISTRY

Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels–Alder Chemistry in Living Systems

(2013) Raffaella Rossin et al.   BIOCONJUGATE CHEMISTRY

Recruiting the Host's Immune System to TargetHelicobacter pylori's Surface Glycans

(2013) Pornchai Kaewsapsak et al.   CHEMBIOCHEM

Fluorescent Live-Cell Imaging of Metabolically Incorporated Unnatural Cyclopropene-Mannosamine Derivatives

(2013) Christian M. Cole et al.   CHEMBIOCHEM

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry

(2013) B. M. Zeglis et al.   JOURNAL OF NUCLEAR MEDICINE

Diels-Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody

(2013) R. Rossin et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of strained alkynes for Cu-free click reaction in live mice

(2013) S.M. van den Bosch et al.   NUCLEAR MEDICINE AND BIOLOGY

State-Selective Metabolic Labeling of Cellular Proteins

(2012) John T. Ngo et al.   ACS Chemical Biology

d-Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen

(2012) M. Sloan Siegrist et al.   ACS Chemical Biology

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles

(2012) Heebeom Koo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amino Acids for Diels-Alder Reactions in Living Cells

(2012) Tilman Plass et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click-Mediated Labeling of Bacterial Membranes through Metabolic Modification of the Lipopolysaccharide Inner Core

(2012) Audrey Dumont et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Situ Probing of Newly Synthesized Peptidoglycan in Live Bacteria with FluorescentD-Amino Acids

(2012) Erkin Kuru et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetic Encoding of a Bicyclo[6.1.0]nonyne-Charged Amino Acid Enables Fast Cellular Protein Imaging by Metal-Free Ligation

(2012) Annika Borrmann et al.   CHEMBIOCHEM

Imaging the Sialome during Zebrafish Development with Copper-Free Click Chemistry

(2012) Karen W. Dehnert et al.   CHEMBIOCHEM

Two-Strain, Cell-Selective Protein Labeling in Mixed Bacterial Cultures

(2012) Frank Truong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

(2012) Kathrin Lang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polar Dibenzocyclooctynes for Selective Labeling of Extracellular Glycoconjugates of Living Cells

(2012) Frédéric Friscourt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorogenic Azidofluoresceins for Biological Imaging

(2012) Peyton Shieh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding the genetic code of Drosophila melanogaster

(2012) Ambra Bianco et al.   Nature Chemical Biology

Reactive polymer enables efficient in vivo bioorthogonal chemistry

(2012) N. K. Devaraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT)

(2012) Jennifer J. L. Hodas et al.   PROTEOMICS

Bioconjugation with Strained Alkenes and Alkynes

(2011) Marjoke F. Debets et al.   ACCOUNTS OF CHEMICAL RESEARCH

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biomedical Applications of Tetrazine Cycloadditions

(2011) Neal K. Devaraj et al.   ACCOUNTS OF CHEMICAL RESEARCH

Metabolic Labeling of Fucosylated Glycans in Developing Zebrafish

(2011) Karen W. Dehnert et al.   ACS Chemical Biology

Noncanonical Amino Acid Labeling in Vivo to Visualize and Affinity Purify Newly Synthesized Proteins in Larval Zebrafish

(2011) Flora I. Hinz et al.   ACS Chemical Neuroscience

Tracking N-Acetyllactosamine on Cell-Surface Glycans In Vivo

(2011) Tianqing Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study

(2011) Christen Besanceney-Webler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation

(2011) Mark R. Karver et al.   BIOCONJUGATE CHEMISTRY

Cell-selective labeling of bacterial proteomes with an orthogonal phenylalanine amino acid reporter

(2011) Markus Grammel et al.   CHEMICAL COMMUNICATIONS

Imaging sialylated tumor cell glycans in vivo

(2011) André A. Neves et al.   FASEB JOURNAL

Expanding the Genetic Code of an Animal

(2011) Sebastian Greiss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Biosynthetic Strategy for Re-engineering theStaphylococcus aureusCell Wall with Non-native Small Molecules

(2010) James W. Nelson et al.   ACS Chemical Biology

Orthogonal Alkynyl Amino Acid Reporter for Selective Labeling of Bacterial Proteomes during Infection

(2010) Markus Grammel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice

(2010) Raffaella Rossin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications

(2010) Jeremiah A Johnson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons

(2010) Daniela C Dieterich et al.   NATURE NEUROSCIENCE

Visualizing enveloping layer glycans during zebrafish early embryogenesis

(2010) J. M. Baskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In VivoImaging ofCaenorhabditis elegansGlycans

(2009) Scott T. Laughlin et al.   ACS Chemical Biology

A Facile System for Encoding Unnatural Amino Acids in Mammalian Cells

(2009) Peng R. Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Engineering of Bacteria Bearing Azido-Pseudaminic Acid-Modified Flagella

(2009) Feng Liu et al.   CHEMBIOCHEM

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

(2009) Marjoke F. Debets et al.   CHEMICAL COMMUNICATIONS

Cell-selective metabolic labeling of proteins

(2009) John T Ngo et al.   Nature Chemical Biology

Metabolic labeling and direct imaging of choline phospholipids in vivo

(2009) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases

(2008) Takahito Mukai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

New Methods Enabling Efficient Incorporation of Unnatural Amino Acids in Yeast

(2008) Qian Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Imaging the glycome

(2008) S. T. Laughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE