Article
Pharmacology & Pharmacy
Fernanda Lopes Conte, Karina Basso Santiago, Bruno Jose Conti, Eliza de Oliveira Cardoso, Lucas Pires Garcia Oliveira, Georgia da Silva Feltran, Willian Fernando Zambuzzi, Marjorie de Assis Golim, Maria Teresa Cruz, Jose Mauricio Sforcin
Summary: The study showed that propolis potentially affects innate immunity by downregulating pro-inflammatory activity of monocytes. Propolis maintained RA's action on cell marker expression, while also inhibiting monocyte responses to certain stimuli such as EtxB and MAGE-1.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Review
Immunology
Yanran Li, Qiyuan Yang, Dongjie Cai, Hongrui Guo, Jing Fang, Hengmin Cui, Liping Gou, Junliang Deng, Zhisheng Wang, Zhicai Zuo
Summary: Resistin, initially proposed as a link between obesity and diabetes in mice, is considered a pro-inflammatory molecule expressed in immune cells in humans, playing a regulatory role in chronic inflammatory diseases, metabolic diseases, infectious diseases, and cancers. However, increasing evidence shows that it functions as a host defense peptide with wide-spectrum anti-microbial activity and immune modulation, limited microbial product-induced inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Locke Davenport Huyer, Serena Mandla, Yufeng Wang, Scott B. Campbell, Bess Yee, Christian Euler, Benjamin F. Lai, A. Dawn Bannerman, Dawn S. Y. Lin, Miles Montgomery, Kayla Nemr, Timothy Bender, Slava Epelman, Radkrishnan Mahadevan, Milica Radisic
Summary: ITA polymers, by leveraging hydrolytic degradation to release ITA, exhibit specific immunoregulatory properties on macrophage polarization in vitro and inhibit bacterial growth on acetate. In an in vivo model of biomaterial associated inflammation, intraperitoneal injection of ITA polymers leads to rapid resolution of inflammation compared to a control polymer silicone, highlighting the significance of sustained biomimetic presentation of ITA.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Immunology
Yudai Matsui, Naoki Takemura, Yoshitaka Shirasaki, Michihiro Takahama, Yoshihiko Noguchi, Kenta Ikoma, Yixi Pan, Shuhei Nishida, Manabu Taura, Akiyoshi Nakayama, Takashi Funatsu, Takuma Misawa, Yoshie Harada, Toshiaki Sunazuka, Tatsuya Saitoh
Summary: In this study, the compound NNM-E derived from Streptomyces was found to effectively inhibit the inflammatory response mediated by NLRP3 inflammasome, with low toxicity.
INTERNATIONAL IMMUNOLOGY
(2022)
Article
Oncology
Joo Dong Park, Kwang-Soo Kim, Seung Hee Choi, Gae Hoon Jo, Jin-Ho Choi, Si-Won Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Hye Jung Jang, Sohyun Hwang, Hae-Yun Jung, Kyung-Soon Park
Summary: This study found that the ELK3-Mid51 axis is directly associated with mitochondrial dynamics and NK cell immune response in TNBC, providing new strategies to improve the efficacy of NK cell-based immunotherapy of TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Microbiology
Hao Peng, Huili Bai, Yan Pan, Jun Li, Zhe Pei, Yuying Liao, Cuilan Wu, Changting Li, Li Tao, Shuhong Zhong, Chunxia Ma, Zhongwei Chen, Xiaoning Li, Yu Gong, Leping Wang, Fengsheng Li
Summary: In this study, different pathogenicity strengths of E. coli strains were observed in C. elegans, and the detection rate of virulence factors did not correspond to the pathogenicity in the nematodes. The results confirmed that C. elegans could serve as a fast and convenient detection model for evaluating the pathogenicity of pathogenic bacteria.
Review
Neurosciences
Eunhee Kim, Sunghee Cho
Summary: Stroke triggers excessive immune activation in the brain tissue, involving intricate interactions between infiltrating peripheral immune cells and resident immune cells. Limited immune cells need to be appropriately distributed between the CNS and periphery to mount a necessary post-stroke inflammatory response while maintaining peripheral immunity. Understanding the distinct roles of CNS and peripheral immunity in their concerted action against ischemic insults is crucial in stroke pathophysiology.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Pablo Rayff da Silva, Renan Fernandes do Espirito Santo, Camila de Oliveira Melo, Fabio Emanuel Pachu Cavalcante, Thassia Borges Costa, Yasmim Vilarim Barbosa, Yvnni M. S. de Medeiros e Silva, Natalia Ferreira de Sousa, Cristiane Flora Villarreal, Ricardo Olimpio de Moura, Vanda Lucia dos Santos
Summary: The compound (E)-2-cyano-N,3-diphenylacrylamide (JMPR-01) shows strong anti-inflammatory potential and could be a potential drug for the treatment of inflammatory diseases.
Review
Pharmacology & Pharmacy
Hamad H. H. Alanazi, Elyasa Elfaki
Summary: Withania somnifera (Ashwagandha) is a botanical drug with various therapeutic effects, such as anti-inflammatory, antioxidant, anticancer, antidiabetic, and anti-asthmatic properties. It promotes immunomodulatory effects and plays a significant role in immunological diseases by regulating cytokines, increasing T-cell proliferation, and enhancing macrophage functions. This review focuses on the latest therapeutic effects of Ashwagandha on various diseases through immunomodulation, as well as its chemical properties and immunomodulatory role in type 2 allergic diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Alice Hamilton, Raffaella Rizzo, Samuel Brod, Masahiro Ono, Mauro Perretti, Dianne Cooper, Fulvio D'Acquisto
Summary: Social isolation has a significant impact on the immune regulation of mice, enhancing their resistance to bacterial infection. Social housing and huddling behavior may be important factors in regulating the host immune response.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Cell Biology
Karolina Maciag, Raktima Raychowdhury, Karen Smith, Alexis M. Schneider, Jorn Coers, Maxwell R. Mumbach, Schraga Schwartz, Nir Hacohen
Summary: In the absence of IRF3, IFN-gamma-primed macrophages more efficiently restricted intracellular pathogens, regardless of traditional immune pathways, suggesting a potentially reversible regulatory mechanism.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nkune Williams Nkune, Nokuphila Winifred Nompumelelo Simelane, Hanieh Montaseri, Heidi Abrahamse
Summary: Photodynamic therapy (PDT) is a promising non-invasive therapy for cancer treatment that can trigger systemic antitumor immune responses. Developing 3D tumor models is of growing interest as they can better mimic the human tumor environment. Future efforts should focus on enhancing PDT immune responses and ideal experimental models for antitumor immune response studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Reza Bayat Mokhtari, Bessi Qorri, Manpreet Sambi, Narges Baluch, Sushil Kumar, Bikul Das, Myron R. Szewczuk, Herman Yeger, Hai-Ling Margaret Cheng
Summary: Breast cancer poses a unique challenge in clinical settings due to the presence of various cell subtypes, including cancer stem cells, which can induce new blood vessel formation and metastatic phenotypes. This study investigated the development of 3D stem-like properties in breast cancer cells cultured in stromal stem cell factor-supplemented media, resulting in successful establishment of orthotopic breast cancer xenografts in athymic nude rats. Targeting therapeutic strategies towards stem cells is crucial for controlling tumor growth and preventing metastasis.
Article
Immunology
Wenny Santaniemi, Pirjo Astrom, Virpi Glumoff, Nora Pernaa, Ella-Noora Tallgren, Sanna Palosaari, Antti Nissinen, Meri Kaustio, Outi Kuismin, Janna Saarela, Katariina Nurmi, Kari K. Eklund, Mikko R. J. Seppanen, Timo Hautala
Summary: In this study, the impact of a heterozygous NFKB1 c.C936T/p.R157X LOF variant on immunity in sterile fasciitis patients and their family members was explored. The variant resulted in reduced p50 or p105 protein levels and elevated IL-1 beta and IL-8 levels, potentially contributing to the high neutrophil counts observed during fasciitis episodes. The variant also led to reduced phosphorylation of p65/RelA in neutrophils, suggesting defective activation of canonical NF-kappa B, and compromised oxidative burst following activation of NF-kappa B-dependent mechanisms.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Oncology
Holden T. Maecker
Summary: Understanding the interaction of SARS-CoV-2 infection with the host immune system, induction of antibody and T cell responses, importance of innate immune responses, and impact of baseline immune profiles and changes on predicting disease progression are crucial for the development of immune monitoring tools for COVID-19.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Neurosciences
Jonathan J. Herrera, Sofiya Fedynska, Parsa R. Ghasem, Tyler Wieman, Peter J. Clark, Nathan Gray, Esteban Loetz, Serge Campeau, Monika Fleshner, Benjamin N. Greenwood
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Agnieszka Mika, Heidi E. W. Day, Alexander Martinez, Nicole L. Rumian, Benjamin N. Greenwood, Maciej Chichlowski, Brian M. Berg, Monika Fleshner
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Review
Cell Biology
Agnieszka Mika, Monika Fleshner
IMMUNOLOGY AND CELL BIOLOGY
(2016)
Article
Infectious Diseases
M. Fleshner, K. N. Olivier, P. A. Shaw, J. Adjemian, S. Strollo, R. J. Claypool, L. Folio, A. Zelazny, S. M. Holland, D. R. Prevots
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2016)
Review
Neurosciences
Monika Fleshner, Matthew Frank, Steven F. Maier
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Anesthesiology
Peter M. Grace, Timothy J. Fabisiak, Suzanne M. Green-Fulgham, Nathan D. Anderson, Keith A. Strand, Andrew J. Kwilasz, Erika L. Galer, Frederick Rohan Walker, Benjamin N. Greenwood, Steven F. Maier, Monika Fleshner, Linda R. Watkins
Article
Multidisciplinary Sciences
Stefan O. Reber, Philip H. Siebler, Nina C. Donner, James T. Morton, David G. Smith, Jared M. Kopelman, Kenneth R. Lowe, Kristen J. Wheeler, James H. Fox, James E. Hassell, Benjamin N. Greenwood, Charline Jansch, Anja Lechner, Dominic Schmidt, Nicole Uschold-Schmidt, Andrea M. Fuechsl, Dominik Langgartner, Frederick R. Walker, Matthew W. Hale, Gerardo Lopez Perez, Will Van Treuren, Antonio Gonzalez, Andrea L. Halweg-Edwards, Monika Fleshner, Charles L. Raison, Graham A. Rook, Shyamal D. Peddada, Rob Knight, Christopher A. Lowry
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Endocrinology & Metabolism
Steven A. Lowrance, Amy Ionadi, Erin McKay, Xavier Douglas, John D. Johnson
PSYCHONEUROENDOCRINOLOGY
(2016)
Article
Behavioral Sciences
Robert S. Thompson, Rachel Roller, Benjamin N. Greenwood, Monika Fleshner
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2016)
Article
Behavioral Sciences
Shyam Seetharaman, Monika Fleshner, Collin R. Park, David M. Diamond
BRAIN AND BEHAVIOR
(2016)
Editorial Material
Immunology
John D. Johnson
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Editorial Material
Immunology
John D. Johnson
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Endocrinology & Metabolism
David F. Barnard, Kristin M. Gabella, Adam C. Kulp, Austin D. Parker, Patrick B. Dugan, John D. Johnson
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Behavioral Sciences
Adam C. Kulp, Brett M. Lowden, Sachi Chaudhari, Cassidy A. Ridley, James C. Krzoska, David F. Barnard, Devanshi M. Mehta, John D. Johnson
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Endocrinology & Metabolism
John D. Johnson, David F. Barnard, Adam C. Kulp, Devanshi M. Mehta
JOURNAL OF THE ENDOCRINE SOCIETY
(2019)