A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures

(2013) Ryan T. Cleary et al.   PLoS One

Blocking seizures with the diuretic bumetanide: Promises and pitfalls

(2012) Yehezkel Ben-Ari   EPILEPSIA

Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy

(2012) Marta Rattka et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia–ischemia model

(2012) YiQing Liu et al.   PEDIATRIC RESEARCH

A randomised controlled trial of bumetanide in the treatment of autism in children

(2012) E Lemonnier et al.   Translational Psychiatry

Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital

(2011) Romain Nardou et al.   BRAIN

Diuretics and epilepsy: Will the past and present meet?

(2011) Edward H. Maa et al.   EPILEPSIA

Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue

(2011) Yijun Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Disease-Modifying Effects of Phenobarbital and the NKCC1 Inhibitor Bumetanide in the Pilocarpine Model of Temporal Lobe Epilepsy

(2010) C. Brandt et al.   JOURNAL OF NEUROSCIENCE

Enhanced susceptibility to the GABA antagonist pentylenetetrazole during the latent period following a pilocarpine-induced status epilepticus in rats

(2010) Marta Rattka et al.   NEUROPHARMACOLOGY

Bumetanide inhibits rapid kindling in neonatal rats

(2009) Andréy Mazarati et al.   EPILEPSIA

Prodrug Approaches for CNS Delivery

(2008) Jarkko Rautio et al.   AAPS Journal

Long-term expressional changes of Na+–K+–Cl− co-transporter 1 (NKCC1) and K+–Cl− co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE)

(2008) Xiubin Li et al.   BRAIN RESEARCH

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology

Bumetanide enhances phenobarbital efficacy in a neonatal seizure model

(2007) Volodymyr I. Dzhala et al.   ANNALS OF NEUROLOGY