Physiological Relevance of Cell Cycle Kinases

Cdc7-Dbf4 Kinase Overexpression in Multiple Cancers and Tumor Cell Lines Is Correlated with p53 Inactivation

(2015) Dorine Bonte et al.   NEOPLASIA

Cell cycle regulators in the control of metabolism

(2011) Emilie Blanchet et al.   CELL CYCLE

The multiple roles of Bub1 in chromosome segregation during mitosis and meiosis

(2011) Francesco Marchetti et al.   CELL CYCLE

Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression

(2011) G. de Carcer et al.   MOLECULAR AND CELLULAR BIOLOGY

The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions

(2010) Eusebio Manchado et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Biophysical and X-ray Crystallographic Analysis of Mps1 Kinase Inhibitor Complexes,

(2010) Matthew L. H. Chu et al.   BIOCHEMISTRY

Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process

(2010) L. Lordier et al.   BLOOD

Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)

(2010) Hannah Carter et al.   CANCER BIOLOGY & THERAPY

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

(2010) Marta Puyol et al.   CANCER CELL

Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

(2010) Eusebio Manchado et al.   CANCER CELL

Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy

(2010) Saskia J.E. Suijkerbuijk et al.   CANCER RESEARCH

Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

(2010) Georg Feldmann et al.   CANCER RESEARCH

Aurora-C and Aurora-B share phosphorylation and regulation of cenp-A and borealin during mitosis

(2010) Scott D. Slattery et al.   CELL CYCLE

The primary microcephaly 3 (MCPH3) interacting protein, p35 and its catalytic subunit, Cdk5, are centrosomal proteins

(2010) Jesusa L. Rosales et al.   CELL CYCLE

Targeting Polo-like Kinase in Cancer Therapy

(2010) Y. Degenhardt et al.   CLINICAL CANCER RESEARCH

Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy

(2010) A. Montagnoli et al.   CLINICAL CANCER RESEARCH

Rec8 Phosphorylation by Casein Kinase 1 and Cdc7-Dbf4 Kinase Regulates Cohesin Cleavage by Separase during Meiosis

(2010) Vittorio L. Katis et al.   DEVELOPMENTAL CELL

Broad-Minded Links Cell Cycle-Related Kinase to Cilia Assembly and Hedgehog Signal Transduction

(2010) Hyuk Wan Ko et al.   DEVELOPMENTAL CELL

Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

(2010) Patrick Schöffski et al.   EUROPEAN JOURNAL OF CANCER

Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis

(2010) Xiaomeng An et al.   EUROPEAN JOURNAL OF CANCER

CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation

(2010) Arijit Mukhopadhyay et al.   HUMAN GENETICS

p35 Is Required for CDK5 Activation in Cellular Senescence

(2010) Daqin Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of NEK6 in Tumor Promoter-induced Transformation in JB6 C141 Mouse Skin Epidermal Cells

(2010) Young Jin Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Cdk5 Suppresses the Neuronal Cell Cycle by Disrupting the E2F1-DP1 Complex

(2010) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Aurora-C Kinase Deficiency Causes Cytokinesis Failure in Meiosis I and Production of Large Polyploid Oocytes in Mice

(2010) Kuo-Tai Yang et al.   MOLECULAR BIOLOGY OF THE CELL

Nek6 Mediates Human Cancer Cell Transformation and Is a Potential Cancer Therapeutic Target

(2010) Rounak Nassirpour et al.   MOLECULAR CANCER RESEARCH

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

(2010) Yi-Jun Sheu et al.   NATURE

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

(2010) Beate Neumann et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

(2010) Nicholas Kwiatkowski et al.   Nature Chemical Biology

The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus

(2010) Zdenek Andrysik et al.   NUCLEIC ACIDS RESEARCH

Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy

(2010) H Salem et al.   ONCOGENE

The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2

(2010) X Zeng et al.   ONCOGENE

Cdk4 Regulates Recruitment of Quiescent β-Cells and Ductal Epithelial Progenitors to Reconstitute β-Cell Mass

(2010) Ji-Hyeon Lee et al.   PLoS One

Plk4 is required for cytokinesis and maintenance of chromosomal stability

(2010) C. O. Rosario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins

(2010) J. R. A. Hutchins et al.   SCIENCE

Cell cycle control of mammalian neural stem cells: putting a speed limit on G1

(2010) Paolo Salomoni et al.   TRENDS IN CELL BIOLOGY

An overview of Cdk1-controlled targets and processes

(2010) Jorrit M Enserink et al.   Cell Division

Cdk5

(2010) Brajendra K. Tripathi et al.   Cell Adhesion & Migration

Mutational Analysis of TTK Gene in Gastric and Colorectal Cancers with Microsatellite Instability

(2010) Chang Hyeok Ahn et al.   Cancer Research and Treatment

Cdk2 Is Required for p53-Independent G2/M Checkpoint Control

(2010) Jon H. Chung et al.   PLoS Genetics

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis

(2009) M. G. Hu et al.   CANCER RESEARCH

Control of cell proliferation in atherosclerosis: insights from animal models and human studies

(2009) J. J. Fuster et al.   CARDIOVASCULAR RESEARCH

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Identification of an Aurora-A/PinsLINKER/ Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells

(2009) Christopher A. Johnston et al.   CELL

Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors

(2009) Christian Lange et al.   Cell Stem Cell

Haspin: a newly discovered regulator of mitotic chromosome behavior

(2009) Jonathan M. G. Higgins   CHROMOSOMA

Cdc7 Kinase Is a Predictor of Survival and a Novel Therapeutic Target in Epithelial Ovarian Carcinoma

(2009) A. A. Kulkarni et al.   CLINICAL CANCER RESEARCH

Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint

(2009) Barry E. McGuinness et al.   CURRENT BIOLOGY

Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view

(2009) Alexander E Kelly et al.   CURRENT OPINION IN CELL BIOLOGY

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

Specification of neurons through asymmetric cell divisions

(2009) Hitoshi Sawa   CURRENT OPINION IN NEUROBIOLOGY

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

Greatwall maintains mitosis through regulation of PP2A

(2009) Suzanne Vigneron et al.   EMBO JOURNAL

Cdc7 kinase – A new target for drug development

(2009) Ronan Swords et al.   EUROPEAN JOURNAL OF CANCER

Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: A mechanism for aneuploidy in cancer

(2009) Qingdu Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

In vivo inactivation of MASTL kinase results in thrombocytopenia

(2009) H. Jan Johnson et al.   EXPERIMENTAL HEMATOLOGY

Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation

(2009) L. I. Francis et al.   GENES & DEVELOPMENT

The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population

(2009) K. Dieterich et al.   HUMAN MOLECULAR GENETICS

Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer

(2009) Matthias Choschzick et al.   HUMAN PATHOLOGY

Cell cycle-related kinase supports ovarian carcinoma cell proliferationviaregulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma

(2009) Guo-Qing Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Phosphorylation of the Par Polarity Complex Protein Par3 at Serine 962 Is Mediated by Aurora A and Regulates Its Function in Neuronal Polarity

(2009) Mohammad R. Khazaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dbf4-Cdc7 Phosphorylation of Mcm2 Is Required for Cell Growth

(2009) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overall Cdk activity modulates the DNA damage response in mammalian cells

(2009) Antonio Cerqueira et al.   JOURNAL OF CELL BIOLOGY

The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons

(2009) J. Chang et al.   JOURNAL OF CELL SCIENCE

TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

(2009) Y.-F. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Differences in DNA Methylation Patterns and Expression of the CCRK Gene in Human and Nonhuman Primate Cortices

(2009) R. Farcas et al.   MOLECULAR BIOLOGY AND EVOLUTION

The M Phase Kinase Greatwall (Gwl) Promotes Inactivation of PP2A/B55δ, a Phosphatase Directed Against CDK Phosphosites

(2009) Priscila V. Castilho et al.   MOLECULAR BIOLOGY OF THE CELL

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

(2009) Mark W. Richards et al.   MOLECULAR CELL

Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry

(2009) Li-Chiou Chuang et al.   MOLECULAR CELL

Cdk1/Cdc28-Dependent Activation of the Major Triacylglycerol Lipase Tgl4 in Yeast Links Lipolysis to Cell-Cycle Progression

(2009) Christoph F. Kurat et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

The CDK4–pRB–E2F1 pathway controls insulin secretion

(2009) Jean-Sébastien Annicotte et al.   NATURE CELL BIOLOGY

Cdk2 suppresses cellular senescence induced by the c-myc oncogene

(2009) Stefano Campaner et al.   NATURE CELL BIOLOGY

An essential role of the aPKC–Aurora A–NDEL1 pathway in neurite elongation by modulation of microtubule dynamics

(2009) Daisuke Mori et al.   NATURE CELL BIOLOGY

Cyclin-dependent kinases: a family portrait

(2009) Marcos Malumbres et al.   NATURE CELL BIOLOGY

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity

(2009) Christopher L. Frank et al.   NEURON

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

(2009) P. Schoffski   ONCOLOGIST

Clinical Experience with Aurora Kinase Inhibitors: A Review

(2009) D. S. Boss et al.   ONCOLOGIST

Plk1-Dependent Recruitment of γ-Tubulin Complexes to Mitotic Centrosomes Involves Multiple PCM Components

(2009) Laurence Haren et al.   PLoS One

Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice

(2009) S. Leland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

(2009) P. Hydbring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

(2009) S. A. Kawashima et al.   SCIENCE

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

Primary microcephaly: do all roads lead to Rome?

(2009) Gemma K. Thornton et al.   TRENDS IN GENETICS

Making a neuron: Cdk5 in embryonic and adult neurogenesis

(2009) Sebastian Jessberger et al.   TRENDS IN NEUROSCIENCES

Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

(2009) Zahra Kadri et al.   PLOS BIOLOGY

Cdc7p-Dbf4p Regulates Mitotic Exit by Inhibiting Polo Kinase

(2009) Charles T. Miller et al.   PLoS Genetics

Polo-box domains confer target specificity to the Polo-like kinase family

(2008) Barbara C.M. van de Weerdt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein phosphatase 2A regulatory subunits and cancer

(2008) Pieter J.A. Eichhorn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Polo-like Kinase 3 Functions as a Tumor Suppressor and Is a Negative Regulator of Hypoxia-Inducible Factor-1  under Hypoxic Conditions

(2008) Y. Yang et al.   CANCER RESEARCH

Nek2 as a novel molecular target for the treatment of breast carcinoma

(2008) Nobuyuki Tsunoda et al.   CANCER SCIENCE

Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization

(2008) Frederik Wirtz-Peitz et al.   CELL

Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomes in Meiosis I

(2008) Joao Matos et al.   CELL

NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells

(2008) Valerie Horsley et al.   CELL

A Cyclin D2–Rb Pathway Regulates Cardiac Myocyte Size and RNA Polymerase III After Biomechanical Stress in Adult Myocardium

(2008) Ekaterini Angelis et al.   CIRCULATION RESEARCH

Aurora Kinases as Anticancer Drug Targets

(2008) O. Gautschi et al.   CLINICAL CANCER RESEARCH

Polo-like kinase 1 reaches beyond mitosis—cytokinesis, DNA damage response, and development

(2008) Tohru Takaki et al.   CURRENT OPINION IN CELL BIOLOGY

The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development

(2008) Lilla M Farkas et al.   CURRENT OPINION IN CELL BIOLOGY

Neurogenesis and asymmetric cell division

(2008) Weimin Zhong et al.   CURRENT OPINION IN NEUROBIOLOGY

Emerging cancer therapeutic opportunities by inhibiting mitotic kinases

(2008) Ignacio Pérez de Castro et al.   CURRENT OPINION IN PHARMACOLOGY

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

(2008) A. Satyanarayana et al.   DEVELOPMENT

Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1

(2008) Mark Petronczki et al.   DEVELOPMENTAL CELL

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

(2008) V. G. Sankaran et al.   GENES & DEVELOPMENT

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

(2008) Z. Ullah et al.   GENES & DEVELOPMENT

Gradual reduction of BUBR1 protein levels results in premature sister-chromatid separation then in aneuploidy

(2008) Elodie Bohers et al.   HUMAN GENETICS

Requirements for Protein Phosphorylation and the Kinase Activity of Polo-like Kinase 1 (Plk1) for the Kinetochore Function of Mitotic Arrest Deficiency Protein 1 (Mad1)

(2008) Ya-Hui Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Novel Cardiac Isoform of the Cell Cycle-related Kinase That Is Regulated during Heart Failure

(2008) Hongyu Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Catalytic Domain of the Mitotic Checkpoint Kinase Mps1 in Complex with SP600125

(2008) Matthew L. H. Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Postsynaptic RapGAP SPAR by Polo-like Kinase 2 and the SCFβ-TRCPUbiquitin Ligase in Hippocampal Neurons

(2008) Xiaolu L. Ang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Polo-like Kinase 3 by Hypoxic Stresses

(2008) Ling Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Cyclin L1 and L2 Interactions with CDK11 and Splicing Factors

(2008) Pascal Loyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

(2008) Kelly J. Inglis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

(2008) Hideki Yokoyama et al.   JOURNAL OF CELL BIOLOGY

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

(2008) Anthony Tighe et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells

(2008) Deborah H. Charych et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phase I Dose Escalation and Pharmacokinetic Study of BI 2536, a Novel Polo-Like Kinase 1 Inhibitor, in Patients With Advanced Solid Tumors

(2008) Klaus Mross et al.   JOURNAL OF CLINICAL ONCOLOGY

Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury

(2008) David A. Liem et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cell cycle control of pituitary development and disease

(2008) Victor Quereda et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Activity-Induced Polo-Like Kinase 2 Is Required for Homeostatic Plasticity of Hippocampal Neurons during Epileptiform Activity

(2008) D. P. Seeburg et al.   JOURNAL OF NEUROSCIENCE

Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality

(2008) Yasunari Yamanaka et al.   MECHANISMS OF DEVELOPMENT

Polo-Like Kinase 1 Is Essential for Early Embryonic Development and Tumor Suppression

(2008) L.-Y. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

Aurora-A Kinase Is Essential for Bipolar Spindle Formation and Early Development

(2008) D. O. Cowley et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Dbf4/Drf1-Dependent Kinase Cdc7 in DNA-Damage Checkpoint Control

(2008) Toshiya Tsuji et al.   MOLECULAR CELL

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

(2008) Morgan E. Carlson et al.   NATURE

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

(2008) Erick J. Morris et al.   NATURE

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

(2008) Alessia Montagnoli et al.   Nature Chemical Biology

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

(2008) Keith W. Orford et al.   NATURE REVIEWS GENETICS

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

(2008) Helfrid Hochegger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical Role of CDK5 and Polo-like Kinase 2 in Homeostatic Synaptic Plasticity during Elevated Activity

(2008) Daniel P. Seeburg et al.   NEURON

TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress

(2008) K Nihira et al.   ONCOGENE

Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology

(2008) S WANG et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

CDK inhibitors in cancer therapy: what is next?

(2007) Marcos Malumbres et al.   TRENDS IN PHARMACOLOGICAL SCIENCES