标题
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
作者
关键词
-
出版物
NATURE REVIEWS MICROBIOLOGY
Volume 14, Issue 8, Pages 479-493
出版商
Springer Nature
发表日期
2016-07-13
DOI
10.1038/nrmicro.2016.87
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase
- (2016) Shuofeng Yuan et al. ANTIVIRAL RESEARCH
- Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle
- (2016) Laura Marcos-Villar et al. JOURNAL OF VIROLOGY
- RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II
- (2016) Mónica Martínez-Alonso et al. JOURNAL OF VIROLOGY
- Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
- (2016) Eric Thierry et al. MOLECULAR CELL
- Species difference in ANP32A underlies influenza A virus polymerase host restriction
- (2016) Jason S. Long et al. NATURE
- A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase
- (2016) Shuofeng Yuan et al. Scientific Reports
- The role of the priming loop in influenza A virus RNA synthesis
- (2016) Aartjan J. W. te Velthuis et al. Nature Microbiology
- Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5
- (2016) Christopher Swale et al. Scientific Reports
- Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter
- (2015) Piotr Gerlach et al. CELL
- Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy
- (2015) Bo Liang et al. CELL
- Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
- (2015) Shashank Tripathi et al. Cell Host & Microbe
- Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza
- (2015) Alexandre Monod et al. Expert Opinion on Drug Discovery
- A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits
- (2015) Serena Massari et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication
- (2015) Lorena S. Ver et al. JOURNAL OF VIROLOGY
- Identification of a Novel Viral Protein Expressed from the PB2 Segment of Influenza A Virus
- (2015) Seiya Yamayoshi et al. JOURNAL OF VIROLOGY
- Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution
- (2015) Shenghai Chang et al. MOLECULAR CELL
- Crystal structure of the RNA-dependent RNA polymerase from influenza C virus
- (2015) Narin Hengrung et al. NATURE
- Advances in the development of influenza virus vaccines
- (2015) Florian Krammer et al. NATURE REVIEWS DRUG DISCOVERY
- Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation
- (2015) David Koppstein et al. NUCLEIC ACIDS RESEARCH
- Influenza A virus preferentially snatches noncoding RNA caps
- (2015) Weifeng Gu et al. RNA
- Structural basis for RNA replication by the hepatitis C virus polymerase
- (2015) T. C. Appleby et al. SCIENCE
- Influenza virus–host interactomes as a basis for antiviral drug development
- (2015) Tokiko Watanabe et al. Current Opinion in Virology
- Phosphorylation at the Homotypic Interface Regulates Nucleoprotein Oligomerization and Assembly of the Influenza Virus Replication Machinery
- (2015) Arindam Mondal et al. PLoS Pathogens
- pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA
- (2015) Kenji Sugiyama et al. eLife
- Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit
- (2014) Randal A. Byrn et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development
- (2014) Tokiko Watanabe et al. Cell Host & Microbe
- Common and unique features of viral RNA-dependent polymerases
- (2014) Aartjan J. W. te Velthuis CELLULAR AND MOLECULAR LIFE SCIENCES
- Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease
- (2014) Hye Yeon Sagong et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2
- (2014) Michael P. Clark et al. JOURNAL OF MEDICINAL CHEMISTRY
- Specific Residues of PB2 and PA Influenza Virus Polymerase Subunits Confer the Ability for RNA Polymerase II Degradation and Virus Pathogenicity in Mice
- (2014) C. M. Llompart et al. JOURNAL OF VIROLOGY
- DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity
- (2014) M. Cao et al. JOURNAL OF VIROLOGY
- Interactome Analysis of the Influenza A Virus Transcription/Replication Machinery Identifies Protein Phosphatase 6 as a Cellular Factor Required for Efficient Virus Replication
- (2014) A. York et al. JOURNAL OF VIROLOGY
- Regulation of Influenza A Virus Nucleoprotein Oligomerization by Phosphorylation
- (2014) Lauren Turrell et al. JOURNAL OF VIROLOGY
- Structural insight into cap-snatching and RNA synthesis by influenza polymerase
- (2014) Stefan Reich et al. NATURE
- Structure of influenza A polymerase bound to the viral RNA promoter
- (2014) Alexander Pflug et al. NATURE
- Coupling mRNA processing with transcription in time and space
- (2014) David L. Bentley NATURE REVIEWS GENETICS
- Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter
- (2014) A. I. Tomescu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins
- (2014) A.V. Vasin et al. VIRUS RESEARCH
- Conserved and host-specific features of influenza virion architecture
- (2014) Edward C. Hutchinson et al. Nature Communications
- Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process
- (2014) Dorota Sikora et al. Scientific Reports
- Recruitment of RED-SMU1 Complex by Influenza A Virus RNA Polymerase to Control Viral mRNA Splicing
- (2014) Guillaume Fournier et al. PLoS Pathogens
- Mechanism of Action of T-705 Ribosyl Triphosphate against Influenza Virus RNA Polymerase
- (2013) Hidehiro Sangawa et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA–PB1 protein–protein interaction
- (2013) Cristina Tintori et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- New 7-Methylguanine Derivatives Targeting the Influenza Polymerase PB2 Cap-Binding Domain
- (2013) Stéphane Pautus et al. JOURNAL OF MEDICINAL CHEMISTRY
- Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus
- (2013) A. York et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biogenesis, assembly, and export of viral messenger ribonucleoproteins in the influenza A virus infected cell
- (2013) Ashley York et al. RNA Biology
- Transport of the Influenza Virus Genome from Nucleus to Nucleus
- (2013) Edward Hutchinson et al. Viruses-Basel
- The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes
- (2013) Lauren Turrell et al. Nature Communications
- The polymerase of negative-stranded RNA viruses
- (2013) Benjamin Morin et al. Current Opinion in Virology
- Cellular RNA Binding Proteins NS1-BP and hnRNP K Regulate Influenza A Virus RNA Splicing
- (2013) Pei-Ling Tsai et al. PLoS Pathogens
- Monomeric Nucleoprotein of Influenza A Virus
- (2013) Sylvie Chenavas et al. PLoS Pathogens
- A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly
- (2012) Chunfeng Li et al. FEBS Journal
- A Small-RNA Enhancer of Viral Polymerase Activity
- (2012) J. T. Perez et al. JOURNAL OF VIROLOGY
- Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase
- (2012) G. Muratore et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Structure of Native Influenza Virion Ribonucleoproteins
- (2012) R. Arranz et al. SCIENCE
- Organization of the Influenza Virus Replication Machinery
- (2012) A. Moeller et al. SCIENCE
- Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
- (2012) Benjamin Mänz et al. Nature Communications
- Emerging Roles for the Influenza A Virus Nuclear Export Protein (NEP)
- (2012) Duncan Paterson et al. PLoS Pathogens
- Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease
- (2012) Rebecca M. DuBois et al. PLoS Pathogens
- Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase
- (2012) Eva Kowalinski et al. PLoS Pathogens
- CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection
- (2011) Roberto Alfonso et al. CELLULAR MICROBIOLOGY
- Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5
- (2011) E. C. Hutchinson et al. JOURNAL OF GENERAL VIROLOGY
- The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein
- (2011) N. C. Robb et al. JOURNAL OF GENERAL VIROLOGY
- Cellular cap-binding proteins associate with influenza virus mRNAs
- (2011) K. Bier et al. JOURNAL OF GENERAL VIROLOGY
- Cellular Human CLE/C14orf166 Protein Interacts with Influenza Virus Polymerase and Is Required for Viral Replication
- (2011) A. Rodriguez et al. JOURNAL OF VIROLOGY
- Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors
- (2011) B. G. Bradel-Tretheway et al. JOURNAL OF VIROLOGY
- The Influenza A Virus NS1 Protein Interacts with the Nucleoprotein of Viral Ribonucleoprotein Complexes
- (2011) N. C. Robb et al. JOURNAL OF VIROLOGY
- Replication-Coupled and Host Factor-Mediated Encapsidation of the Influenza Virus Genome by Viral Nucleoprotein
- (2011) A. Kawaguchi et al. JOURNAL OF VIROLOGY
- The influenza virus RNA synthesis machine
- (2011) Patricia Resa-Infante et al. RNA Biology
- Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins
- (2011) E. Bortz et al. mBio
- Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit
- (2011) Franck Tarendeau et al. PLoS Pathogens
- The Splicing Factor Proline-Glutamine Rich (SFPQ/PSF) Is Involved in Influenza Virus Transcription
- (2011) Sara Landeras-Bueno et al. PLoS Pathogens
- Influenza Virus Ribonucleoprotein Complexes Gain Preferential Access to Cellular Export Machinery through Chromatin Targeting
- (2011) Geoffrey P. Chase et al. PLoS Pathogens
- Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase
- (2010) Kerstin Wunderlich et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In Vitro Antiviral Activity of Favipiravir (T-705) against Drug-Resistant Influenza and 2009 A(H1N1) Viruses
- (2010) K. Sleeman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Disruption of the Viral Polymerase Complex Assembly as a Novel Approach to Attenuate Influenza A Virus
- (2010) Benjamin Mänz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional Analysis of the Influenza Virus H5N1 Nucleoprotein Tail Loop Reveals Amino Acids That Are Crucial for Oligomerization and Ribonucleoprotein Activities
- (2010) W.-H. Chan et al. JOURNAL OF VIROLOGY
- Structural and Functional Characterization of an Influenza Virus RNA Polymerase-Genomic RNA Complex
- (2010) Patricia Resa-Infante et al. JOURNAL OF VIROLOGY
- Association of the Influenza Virus RNA Polymerase Subunit PB2 with the Host Chaperonin CCT
- (2010) T. Fislova et al. JOURNAL OF VIROLOGY
- Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
- (2010) Alexander Karlas et al. NATURE
- Influenza A virus-generated small RNAs regulate the switch from transcription to replication
- (2010) J. T. Perez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human importin alpha and RNA do not compete for binding to influenza A virus nucleoprotein
- (2010) Sébastien Boulo et al. VIROLOGY
- Influenza A Virus Expresses High Levels of an Unusual Class of Small Viral Leader RNAs in Infected Cells
- (2010) J. L. Umbach et al. mBio
- The role of the influenza virus RNA polymerase in host shut-off
- (2010) Frank T. Vreede et al. Virulence
- A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection
- (2009) Sagi D. Shapira et al. CELL
- The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus
- (2009) Abraham L. Brass et al. CELL
- Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase
- (2009) Kanako Sugiyama et al. EMBO JOURNAL
- NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome
- (2009) Nicole C. Robb et al. JOURNAL OF GENERAL VIROLOGY
- Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site
- (2009) Puwei Yuan et al. NATURE
- The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
- (2009) Alexandre Dias et al. NATURE
- Human host factors required for influenza virus replication
- (2009) Renate König et al. NATURE
- The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza
- (2009) Baoquan Sui et al. VIROLOGY
- Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells
- (2009) Frank T. Vreede et al. VIROLOGY
- Genetic trans-Complementation Establishes a New Model for Influenza Virus RNA Transcription and Replication
- (2009) Núria Jorba et al. PLoS Pathogens
- Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design
- (2008) Andy Ka-Leung Ng et al. FASEB JOURNAL
- Oligomerization of the influenza virus polymerase complex in vivo
- (2008) N. Jorba et al. JOURNAL OF GENERAL VIROLOGY
- Interaction of the Influenza A Virus Nucleocapsid Protein with the Viral RNA Polymerase Potentiates Unprimed Viral RNA Replication
- (2008) L. L. Newcomb et al. JOURNAL OF VIROLOGY
- Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus
- (2008) Xiaojing He et al. NATURE
- The structural basis for an essential subunit interaction in influenza virus RNA polymerase
- (2008) Eiji Obayashi et al. NATURE
- Drosophila RNAi screen identifies host genes important for influenza virus replication
- (2008) Linhui Hao et al. NATURE
- The structural basis for cap binding by influenza virus polymerase subunit PB2
- (2008) Delphine Guilligay et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Host-Dependent Interaction of α-Importins with Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication
- (2008) Patricia Resa-Infante et al. PLoS One
- Analysis of the interaction of influenza virus polymerase complex with human cell factors
- (2008) Núria Jorba et al. PROTEOMICS
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