Liver — guardian, modifier and target of sepsis

The interplay between regulated necrosis and bacterial infection

(2016) Camille Blériot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Iron Parameters Determine the Prognosis of Critically Ill Patients*

(2016) Frank Tacke et al.   CRITICAL CARE MEDICINE

Terlipressin Plus Albumin Is More Effective Than Albumin Alone in Improving Renal Function in Patients With Cirrhosis and Hepatorenal Syndrome Type 1

(2016) Thomas D. Boyer et al.   GASTROENTEROLOGY

An empirical broad spectrum antibiotic therapy in health-care-associated infections improves survival in patients with cirrhosis: A randomized trial

(2016) Manuela Merli et al.   HEPATOLOGY

Antibiotic prophylaxis in cirrhosis: Good and bad

(2016) Javier Fernández et al.   HEPATOLOGY

Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver

(2016) Nam-On Ku et al.   HEPATOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High volume plasma exchange in acute liver failure: Dampening the inflammatory cascade?

(2016) Constantine J. Karvellas et al.   JOURNAL OF HEPATOLOGY

High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial

(2016) Fin Stolze Larsen et al.   JOURNAL OF HEPATOLOGY

Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure

(2016) Rajeshwar P. Mookerjee et al.   JOURNAL OF HEPATOLOGY

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Appropriate and timely antimicrobial therapy in cirrhotic patients with spontaneous bacterial peritonitis-associated septic shock: a retrospective cohort study

(2015) C. J. Karvellas et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical and Pathophysiological Consequences of Alterations in the Microbiome in Cirrhosis

(2015) Jane Macnaughtan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Hepatic Hepcidin Protects against Polymicrobial Sepsis in Mice by Regulating Host Iron Status

(2015) CongLi Zeng et al.   ANESTHESIOLOGY

Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus

(2015) João Arezes et al.   Cell Host & Microbe

The Regulation of Endotoxin Tolerance and its Impact on Macrophage Activation

(2015) Patricia E. Collins et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Combination of Granulocyte Colony-Stimulating Factor and Erythropoietin Improves Outcomes of Patients With Decompensated Cirrhosis

(2015) Chandan Kumar Kedarisetty et al.   GASTROENTEROLOGY

UK guidelines on the management of variceal haemorrhage in cirrhotic patients

(2015) Dhiraj Tripathi et al.   GUT

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: Results of a randomized, controlled clinical trial

(2015) Salvatore Piano et al.   HEPATOLOGY

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

Sepsis-induced acute kidney injury in patients with cirrhosis

(2015) Paolo Angeli et al.   Hepatology International

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

(2015) Camille Blériot et al.   IMMUNITY

Effect of albumin in cirrhotic patients with infection other than spontaneous bacterial peritonitis. A randomized trial

(2015) Thierry Thévenot et al.   JOURNAL OF HEPATOLOGY

Expanding consensus in portal hypertension

(2015) Roberto de Franchis   JOURNAL OF HEPATOLOGY

Implications of microbiota and bile acid in liver injury and regeneration

(2015) Hui-Xin Liu et al.   JOURNAL OF HEPATOLOGY

Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis

(2015) Mauro Bernardi et al.   JOURNAL OF HEPATOLOGY

Microbiological analysis of bile and its impact in critically ill patients with secondary sclerosing cholangitis

(2015) Torsten Voigtländer et al.   JOURNAL OF INFECTION

Laser speckle contrast imaging for measurement of hepatic microcirculation during the sepsis: A novel tool for early detection of microcirculation dysfunction

(2015) Yin Wu et al.   MICROVASCULAR RESEARCH

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

New antibiotic strategies in patients with cirrhosis and bacterial infection

(2015) Javier Fernández et al.   Expert Review of Gastroenterology & Hepatology

Early Hepatic Dysfunction Is Associated with a Worse Outcome in Patients Presenting with Acute Respiratory Distress Syndrome: A Post-Hoc Analysis of the ACURASYS and PROSEVA Studies

(2015) Stéphanie Dizier et al.   PLoS One

Prevalence and in-hospital mortality trends of infections among patients with cirrhosis: a nationwide study of hospitalised patients in the United States

(2014) A. K. Singal et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Integrative “Omic” Analysis of Experimental Bacteremia Identifies a Metabolic Signature That Distinguishes Human Sepsis from Systemic Inflammatory Response Syndromes

(2014) Raymond J. Langley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients

(2014) Frank Tacke et al.   CRITICAL CARE MEDICINE

Scaling of immune responses against intracellular bacterial infection

(2014) Z. Abdullah et al.   EMBO JOURNAL

Nonselective β Blockers Increase Risk for Hepatorenal Syndrome and Death in Patients With Cirrhosis and Spontaneous Bacterial Peritonitis

(2014) Mattias Mandorfer et al.   GASTROENTEROLOGY

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

Non-selective β-blockers are associated with improved survival in patients with ascites listed for liver transplantation

(2014) Joanna A Leithead et al.   GUT

Pathology of the liver sinusoids

(2014) Elizabeth M Brunt et al.   HISTOPATHOLOGY

The Role of the Liver in Sepsis

(2014) Jun Yan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Terlipressin and albumin for type-1 hepatorenal syndrome associated with sepsis

(2014) Ezequiel Rodríguez et al.   JOURNAL OF HEPATOLOGY

Statin therapy is associated with reduced incidence of hypoxic hepatitis in critically ill patients

(2014) Andreas Drolz et al.   JOURNAL OF HEPATOLOGY

Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013

(2014) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

Liver sinusoidal endothelial dysfunction after LPS administration: A role for inducible-nitric oxide synthase

(2014) Vincenzo La Mura et al.   JOURNAL OF HEPATOLOGY

Epidemiology and outcomes of bloodstream infection in patients with cirrhosis

(2014) Michele Bartoletti et al.   JOURNAL OF HEPATOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases

(2014) Christoph Roderburg et al.   LIVER INTERNATIONAL

Healthcare-associated and nosocomial bacterial infections in cirrhosis: predictors and impact on outcome

(2014) Konstantina Sargenti et al.   LIVER INTERNATIONAL

The role of hepatic immune regulation in systemic immunity to viral infection

(2014) Percy A. Knolle et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Serum Levels of Caspase-Cleaved Cytokeratin-18 and Mortality Are Associated in Severe Septic Patients: Pilot Study

(2014) Leonardo Lorente et al.   PLoS One

In Vivo Characterization of Neutrophil Extracellular Traps in Various Organs of a Murine Sepsis Model

(2014) Koji Tanaka et al.   PLoS One

Risk factors and outcome of bacterial infections in cirrhosis

(2014) Tony Bruns   WORLD JOURNAL OF GASTROENTEROLOGY

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

The liver in sepsis

(2013) Michael Bauer et al.   Current Opinion in Critical Care

Hypoxic liver injury and cholestasis in critically ill patients

(2013) Thomas Horvatits et al.   Current Opinion in Critical Care

Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

(2013) Richard Moreau et al.   GASTROENTEROLOGY

Type-1 hepatorenal syndrome associated with infections in cirrhosis: Natural history, outcome of kidney function, and survival

(2013) Rogelio Barreto et al.   HEPATOLOGY

Clinical impact of arterial ammonia levels in ICU patients with different liver diseases

(2013) Andreas Drolz et al.   INTENSIVE CARE MEDICINE

Pathological bacterial translocation in liver cirrhosis

(2013) Reiner Wiest et al.   JOURNAL OF HEPATOLOGY

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

(2013) Anna Moles et al.   JOURNAL OF HEPATOLOGY

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

(2013) Li-Rung Huang et al.   NATURE IMMUNOLOGY

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Liver-spleen axis: Intersection between immunity, infections and metabolism

(2013) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

Interpretation of C-Reactive Protein Concentrations in Critically Ill Patients

(2013) Christophe Lelubre et al.   Biomed Research International

Acquired Liver Injury in the Intensive Care Unit

(2012) Thomas Lescot et al.   ANESTHESIOLOGY

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Retraction notice to “Myeloid-derived suppressor cells accumulate in the liver site after sepsis to induce immunosuppression” Cellular Immunology 279 (2012) 12–20

(2012) Dongping Ren et al.   CELLULAR IMMUNOLOGY

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary

(2012) Patrick T. O’Gara et al.   CIRCULATION

A Pilot Study Assessing the Prognostic Value of CK18 and nDNA Biomarkers in Severe Sepsis Patients

(2012) David J. Moore et al.   CLINICAL DRUG INVESTIGATION

Diagnostic bedside EUS in the intensive care unit: a single-center experience

(2012) Manuel Berzosa et al.   GASTROINTESTINAL ENDOSCOPY

Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol

(2012) Thomas Reiberger et al.   GUT

Jaundice increases the rate of complications and one-year mortality in patients with hypoxic hepatitis

(2012) Bernhard Jäger et al.   HEPATOLOGY

Antimicrobial therapeutic determinants of outcomes from septic shock among patients with cirrhosis

(2012) Yaseen M. Arabi et al.   HEPATOLOGY

Second infections independently increase mortality in hospitalized patients With cirrhosis: the north american consortium for the study of end-stage liver disease (NACSELD) experience

(2012) Jasmohan S. Bajaj et al.   HEPATOLOGY

Renal failure and hyponatremia in patients with cirrhosis and skin and soft tissue infection. A retrospective study

(2012) Gustavo Pereira et al.   JOURNAL OF HEPATOLOGY

Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study

(2012) Mónica Guevara et al.   JOURNAL OF HEPATOLOGY

Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis

(2012) Thomas Reiberger et al.   JOURNAL OF HEPATOLOGY

Selective Expansion of Allogeneic Regulatory T Cells by Hepatic Stellate Cells: Role of Endotoxin and Implications for Allograft Tolerance

(2012) A. Dangi et al.   JOURNAL OF IMMUNOLOGY

Hepcidin and the Iron-Infection Axis

(2012) H. Drakesmith et al.   SCIENCE

Innate Response Activator B Cells Protect Against Microbial Sepsis

(2012) P. J. Rauch et al.   SCIENCE

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

New Translational Research Provides Insights into Liver Dysfunction in Sepsis

(2012) John C. Marshall   PLOS MEDICINE

Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

(2012) Peter Recknagel et al.   PLOS MEDICINE

Comparison of Sepsis-Induced Transcriptomic Changes in a Murine Model to Clinical Blood Samples Identifies Common Response Patterns

(2012) Sandro Lambeck et al.   Frontiers in Microbiology

Targeting Nuclear Bile Acid Receptors for Liver Disease

(2011) Michael Trauner et al.   DIGESTIVE DISEASES

Hepatic acute phase proteins – Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

(2011) Johannes G. Bode et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers

(2011) Lucia Russo et al.   HEPATOLOGY

LPS pretreatment ameliorates multiple organ injuries and improves survival in a murine model of polymicrobial sepsis

(2011) Dong-Wei Shi et al.   INFLAMMATION RESEARCH

Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study

(2011) R. Moreno et al.   INTENSIVE CARE MEDICINE

Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis

(2011) H.D. Nischalke et al.   JOURNAL OF HEPATOLOGY

Dynamics of Hepatic Gene Expression Profile in a Rat Cecal Ligation and Puncture Model

(2011) Qian Yang et al.   JOURNAL OF SURGICAL RESEARCH

Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis

(2010) Vasiliki Arvaniti et al.   GASTROENTEROLOGY

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

(2010) Leif E. Sander et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia–reperfusion injury

(2010) Laura Llacuna et al.   JOURNAL OF HEPATOLOGY

The Role of Inflammation in Cholestasis: Clinical and Basic Aspects

(2010) Astrid Kosters et al.   SEMINARS IN LIVER DISEASE

Oral Antibiotic Prophylaxis Reduces Spontaneous Bacterial Peritonitis Occurrence and Improves Short-Term Survival in Cirrhosis: A Meta-Analysis

(2009) Sammy Saab et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Catecholamines induce an inflammatory response in human hepatocytes

(2009) Caroline Aninat et al.   CRITICAL CARE MEDICINE

Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis

(2009) Beate Appenrodt et al.   HEPATOLOGY

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism

(2009) Melanie J. Scott et al.   HEPATOLOGY

Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients

(2009) Valentin Fuhrmann et al.   INTENSIVE CARE MEDICINE

Sepsis, complement and the dysregulated inflammatory response

(2009) Peter A. Ward et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Effect of Strict Blood Glucose Control on Biliary Sludge and Cholestasis in Critically Ill Patients

(2009) Dieter Mesotten et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The use of β-adrenergic drugs improves hepatic oxygen metabolism in cirrhotic patients undergoing liver resection

(2009) Pilar Taurà et al.   JOURNAL OF HEPATOLOGY

Liver Perfusion in Sepsis, Septic Shock, and Multiorgan Failure

(2008) Herbert Spapen   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Inflammatory Pathways in Liver Homeostasis and Liver Injury

(2008) Frank Tacke et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Poor outcome in progressive sclerosing cholangitis after septic shock

(2008) H. Kulaksiz et al.   ENDOSCOPY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Hydrocortisone Therapy for Patients with Septic Shock

(2008) Charles L. Sprung et al.   NEW ENGLAND JOURNAL OF MEDICINE