Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

The polygenic profiles in participants with achilles tendinopathy and controls

(2011) M. Posthumus et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Genetic contributions to the association between adult height and testicular germ cell tumors

(2011) M. B. Cook et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus

(2011) A.W. Dodd et al.   OSTEOARTHRITIS AND CARTILAGE

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

(2010) M. Daans et al.   ANNALS OF THE RHEUMATIC DISEASES

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance

(2010) A. M. Valdes et al.   ANNALS OF THE RHEUMATIC DISEASES

Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes

(2010) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women

(2010) F. M. K. Williams et al.   ARTHRITIS AND RHEUMATISM

Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring

(2010) Jill A. McKay et al.   Genes and Nutrition

Epigenetic alterations in aging

(2010) Susana Gonzalo   JOURNAL OF APPLIED PHYSIOLOGY

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Evidence of association between GDF5 polymorphisms and congenital dislocation of the hip in a Caucasian population

(2010) K. Rouault et al.   OSTEOARTHRITIS AND CARTILAGE

Components of the transforming growth factor-  family and the pathogenesis of human Achilles tendon pathology--a genetic association study

(2010) M. Posthumus et al.   RHEUMATOLOGY

Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand

(2009) Evangelos Evangelou et al.   ARTHRITIS AND RHEUMATISM

Functional analysis of the osteoarthritis susceptibility-associatedGDF5regulatory polymorphism

(2009) Rainer J. Egli et al.   ARTHRITIS AND RHEUMATISM

DNA methylation profiles in monozygotic and dizygotic twins

(2009) Zachary A Kaminsky et al.   NATURE GENETICS

Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study

(2008) R B A Vaes et al.   ANNALS OF THE RHEUMATIC DISEASES

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility

(2008) K. Chapman et al.   HUMAN MOLECULAR GENETICS

Intra-individual Change Over Time in DNA Methylation With Familial Clustering

(2008) Hans T. Bjornsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage

(2008) Marco A. da Silva et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Common variants in the GDF5-UQCC region are associated with variation in human height

(2008) Serena Sanna et al.   NATURE GENETICS

Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage

(2008) R.F. Loeser et al.   OSTEOARTHRITIS AND CARTILAGE

DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes

(2008) S. Sesselmann et al.   OSTEOARTHRITIS AND CARTILAGE

Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation

(2008) Kelvin S. C. Cheung et al.   RHEUMATOLOGY INTERNATIONAL

Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study

(2008) Jin Dai et al.   ARTHRITIS RESEARCH & THERAPY